FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113001489> ?p ?o ?g. }

• W2113001489 endingPage "1199" @default.
• W2113001489 startingPage "1189" @default.
• W2113001489 abstract "Epidemiological studies indicate that cigarette smoke exposure is a risk factor for increased sensitisation and asthma development. The aim of this study was to examine the impact of cigarette smoke on sensitisation and allergic airway inflammation in response to a low dose of house dust mite (HDM), and to obtain potential mechanistic insights. Mice were exposed to low doses of HDM extract combined with air or cigarette smoke exposure, either during allergen sensitisation or during the development of allergic airway disease. Mice concomitantly exposed to low-dose HDM, combined with cigarette smoke for 3 weeks, demonstrated an asthmatic phenotype with significantly increased airway eosinophilia, goblet cell metaplasia, airway hyperresponsiveness and a rise in HDM-specific serum immunoglobulin G1, compared to sole HDM or cigarette smoke exposure. In addition, short cigarette smoke inhalation, during the initial contact with HDM allergens, was sufficient to facilitate sensitisation and development of a complete asthmatic phenotype after rechallenge with HDM. Mechanistically, short cigarette smoke exposure amplified dendritic cell-mediated transport of fluorescein isothiocyanate-labelled HDM allergens to the intrathoracic lymph nodes and generated a local T-helper cell type 2 response. Short cigarette smoke exposure is sufficient to facilitate allergic sensitisation and the development of low-dose HDM-induced allergic asthma, possibly by affecting dendritic cell function." @default.
• W2113001489 created "2016-06-24" @default.
• W2113001489 creator A5000243872 @default.
• W2113001489 creator A5014740733 @default.
• W2113001489 creator A5036231436 @default.
• W2113001489 creator A5057962875 @default.
• W2113001489 creator A5078648107 @default.
• W2113001489 creator A5078704594 @default.
• W2113001489 creator A5080249904 @default.
• W2113001489 date "2012-08-16" @default.
• W2113001489 modified "2023-10-02" @default.
• W2113001489 title "Short cigarette smoke exposure facilitates sensitisation and asthma development in mice" @default.
• W2113001489 cites W1494153940 @default.
• W2113001489 cites W1499900378 @default.
• W2113001489 cites W1585473951 @default.
• W2113001489 cites W1613133166 @default.
• W2113001489 cites W1938875651 @default.
• W2113001489 cites W1963985834 @default.
• W2113001489 cites W1967361516 @default.
• W2113001489 cites W1983715304 @default.
• W2113001489 cites W1986715928 @default.
• W2113001489 cites W1994573937 @default.
• W2113001489 cites W1995727724 @default.
• W2113001489 cites W2022139101 @default.
• W2113001489 cites W2029786587 @default.
• W2113001489 cites W2031565955 @default.
• W2113001489 cites W2063424064 @default.
• W2113001489 cites W2065087108 @default.
• W2113001489 cites W2071439633 @default.
• W2113001489 cites W2079699037 @default.
• W2113001489 cites W2080536639 @default.
• W2113001489 cites W2093032030 @default.
• W2113001489 cites W2096594260 @default.
• W2113001489 cites W2101664092 @default.
• W2113001489 cites W2106287633 @default.
• W2113001489 cites W2110085609 @default.
• W2113001489 cites W2112282810 @default.
• W2113001489 cites W2113075038 @default.
• W2113001489 cites W2118238722 @default.
• W2113001489 cites W2124097427 @default.
• W2113001489 cites W2138760399 @default.
• W2113001489 cites W2146409607 @default.
• W2113001489 cites W2151563637 @default.
• W2113001489 cites W2156972485 @default.
• W2113001489 cites W2160213796 @default.
• W2113001489 cites W2161530489 @default.
• W2113001489 cites W2163574165 @default.
• W2113001489 cites W2163969882 @default.
• W2113001489 cites W592102630 @default.
• W2113001489 doi "https://doi.org/10.1183/09031936.00096612" @default.
• W2113001489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22903968" @default.
• W2113001489 hasPublicationYear "2012" @default.
• W2113001489 type Work @default.
• W2113001489 sameAs 2113001489 @default.
• W2113001489 citedByCount "42" @default.
• W2113001489 countsByYear W21130014892014 @default.
• W2113001489 countsByYear W21130014892015 @default.
• W2113001489 countsByYear W21130014892016 @default.
• W2113001489 countsByYear W21130014892017 @default.
• W2113001489 countsByYear W21130014892018 @default.
• W2113001489 countsByYear W21130014892019 @default.
• W2113001489 countsByYear W21130014892020 @default.
• W2113001489 countsByYear W21130014892021 @default.
• W2113001489 countsByYear W21130014892023 @default.
• W2113001489 crossrefType "journal-article" @default.
• W2113001489 hasAuthorship W2113001489A5000243872 @default.
• W2113001489 hasAuthorship W2113001489A5014740733 @default.
• W2113001489 hasAuthorship W2113001489A5036231436 @default.
• W2113001489 hasAuthorship W2113001489A5057962875 @default.
• W2113001489 hasAuthorship W2113001489A5078648107 @default.
• W2113001489 hasAuthorship W2113001489A5078704594 @default.
• W2113001489 hasAuthorship W2113001489A5080249904 @default.
• W2113001489 hasBestOaLocation W21130014891 @default.
• W2113001489 hasConcept C142724271 @default.
• W2113001489 hasConcept C203014093 @default.
• W2113001489 hasConcept C207480886 @default.
• W2113001489 hasConcept C2775941134 @default.
• W2113001489 hasConcept C2776042228 @default.
• W2113001489 hasConcept C2777129736 @default.
• W2113001489 hasConcept C2778166374 @default.
• W2113001489 hasConcept C2780510475 @default.
• W2113001489 hasConcept C529295009 @default.
• W2113001489 hasConcept C71924100 @default.
• W2113001489 hasConceptScore W2113001489C142724271 @default.
• W2113001489 hasConceptScore W2113001489C203014093 @default.
• W2113001489 hasConceptScore W2113001489C207480886 @default.
• W2113001489 hasConceptScore W2113001489C2775941134 @default.
• W2113001489 hasConceptScore W2113001489C2776042228 @default.
• W2113001489 hasConceptScore W2113001489C2777129736 @default.
• W2113001489 hasConceptScore W2113001489C2778166374 @default.
• W2113001489 hasConceptScore W2113001489C2780510475 @default.
• W2113001489 hasConceptScore W2113001489C529295009 @default.
• W2113001489 hasConceptScore W2113001489C71924100 @default.
• W2113001489 hasIssue "5" @default.
• W2113001489 hasLocation W21130014891 @default.
• W2113001489 hasLocation W21130014892 @default.
• W2113001489 hasOpenAccess W2113001489 @default.
• W2113001489 hasPrimaryLocation W21130014891 @default.

• next