Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113011235> ?p ?o ?g. }
- W2113011235 endingPage "1390" @default.
- W2113011235 startingPage "1375" @default.
- W2113011235 abstract "Mouse models of Huntington's disease (HD) recapitulate many aspects of the human disease. These genetically modified mice are powerful tools that are used not only to examine the pathogenesis of the disease, but also to assess the efficacy of potential new treatments. Disappointingly, in the past few years we have seen the success of potential therapies in animal studies, subsequently followed by failure in clinical trials. We discuss here a number of factors that influence the translatability of findings from the preclinical to the clinical realm. In particular, we discuss issues related to sample size, reporting of information regarding experimental protocols and mouse models, assignment to experimental groups, incorporation of cognitive measures for early phases of the disease, environmental enrichment, surrogate measures for survival, and the use of more than one HD mouse model. Although it is reasonable to question the appropriateness of the animal models used, we argue that it is more parsimonious to assume that improvements in experimental design and publication of negative results will lead to improved translatability to the clinic and insights about HD pathophysiology. © 2014 International Parkinson and Movement Disorder Society" @default.
- W2113011235 created "2016-06-24" @default.
- W2113011235 creator A5014199484 @default.
- W2113011235 creator A5058804618 @default.
- W2113011235 date "2014-09-12" @default.
- W2113011235 modified "2023-10-18" @default.
- W2113011235 title "Animal models of Huntington's disease for translation to the clinic: Best practices" @default.
- W2113011235 cites W137871220 @default.
- W2113011235 cites W1509701720 @default.
- W2113011235 cites W1515840075 @default.
- W2113011235 cites W1639255528 @default.
- W2113011235 cites W1750171938 @default.
- W2113011235 cites W1797863618 @default.
- W2113011235 cites W1892455234 @default.
- W2113011235 cites W1949056714 @default.
- W2113011235 cites W1965247936 @default.
- W2113011235 cites W1967172001 @default.
- W2113011235 cites W1972251644 @default.
- W2113011235 cites W1974456128 @default.
- W2113011235 cites W1976205692 @default.
- W2113011235 cites W1978662219 @default.
- W2113011235 cites W1984444180 @default.
- W2113011235 cites W1987000223 @default.
- W2113011235 cites W1987777080 @default.
- W2113011235 cites W1991480442 @default.
- W2113011235 cites W1991686179 @default.
- W2113011235 cites W1991964306 @default.
- W2113011235 cites W1992105552 @default.
- W2113011235 cites W1994473527 @default.
- W2113011235 cites W1994742944 @default.
- W2113011235 cites W1997547334 @default.
- W2113011235 cites W1997626531 @default.
- W2113011235 cites W1997883336 @default.
- W2113011235 cites W2000640243 @default.
- W2113011235 cites W2002062153 @default.
- W2113011235 cites W2004969253 @default.
- W2113011235 cites W2013361409 @default.
- W2113011235 cites W2013444252 @default.
- W2113011235 cites W2017645644 @default.
- W2113011235 cites W2020195827 @default.
- W2113011235 cites W2024570377 @default.
- W2113011235 cites W2025757297 @default.
- W2113011235 cites W2026274927 @default.
- W2113011235 cites W2027275070 @default.
- W2113011235 cites W2028639234 @default.
- W2113011235 cites W2035689987 @default.
- W2113011235 cites W2040269286 @default.
- W2113011235 cites W2040308828 @default.
- W2113011235 cites W2041119962 @default.
- W2113011235 cites W2041371057 @default.
- W2113011235 cites W2043762704 @default.
- W2113011235 cites W2047638794 @default.
- W2113011235 cites W2048323087 @default.
- W2113011235 cites W2052835747 @default.
- W2113011235 cites W2057091932 @default.
- W2113011235 cites W2057647416 @default.
- W2113011235 cites W2060750433 @default.
- W2113011235 cites W2060835116 @default.
- W2113011235 cites W2062470622 @default.
- W2113011235 cites W2062682951 @default.
- W2113011235 cites W2067833766 @default.
- W2113011235 cites W2068995040 @default.
- W2113011235 cites W2071331572 @default.
- W2113011235 cites W2073483777 @default.
- W2113011235 cites W2074113392 @default.
- W2113011235 cites W2074533563 @default.
- W2113011235 cites W2082938488 @default.
- W2113011235 cites W2083040497 @default.
- W2113011235 cites W2084728929 @default.
- W2113011235 cites W2087656730 @default.
- W2113011235 cites W2091011066 @default.
- W2113011235 cites W2095387147 @default.
- W2113011235 cites W2096192426 @default.
- W2113011235 cites W2096232244 @default.
- W2113011235 cites W2102945991 @default.
- W2113011235 cites W2104054545 @default.
- W2113011235 cites W2105465219 @default.
- W2113011235 cites W2105824687 @default.
- W2113011235 cites W2107356497 @default.
- W2113011235 cites W2107514471 @default.
- W2113011235 cites W2107522917 @default.
- W2113011235 cites W2109963121 @default.
- W2113011235 cites W2109964336 @default.
- W2113011235 cites W2112793851 @default.
- W2113011235 cites W2122853309 @default.
- W2113011235 cites W2122916113 @default.
- W2113011235 cites W2124661414 @default.
- W2113011235 cites W2125105780 @default.
- W2113011235 cites W2137516955 @default.
- W2113011235 cites W2137527705 @default.
- W2113011235 cites W2142125979 @default.
- W2113011235 cites W2143116460 @default.
- W2113011235 cites W2144981148 @default.
- W2113011235 cites W2145582145 @default.
- W2113011235 cites W2147480509 @default.
- W2113011235 cites W2150215887 @default.
- W2113011235 cites W2154022596 @default.
- W2113011235 cites W2158174988 @default.