Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113011946> ?p ?o ?g. }
- W2113011946 endingPage "217" @default.
- W2113011946 startingPage "206" @default.
- W2113011946 abstract "Cow's milk proteins cause allergic symptoms in 2-3% of all infants. In these individuals, the tolerogenic state of the intestinal immune system is broken, which can lead to sensitization against antigens and eventually to allergic responses. Although a true treatment for food allergy is not available, symptoms can be avoided by providing the infants with hydrolyzed proteins. Hydrolyzed proteins are proteins that are enzymatically degraded. They lack typical allergenic IgE-binding epitopes but are also thought to play a pertinent role in other mechanisms inducing hypoallergenic effects. This review discusses the mechanisms and evidence for immunomodulating properties of cow's milk hydrolysates. Hydrolysates are found to strengthen the epithelial barrier, modulate T-cell differentiation, and decrease inflammation. Some studies suggest a role for hydrolysates in manipulating pathogen recognition receptors signaling as underlying mechanism. Peptides from hydrolysates have been shown to bind to TLR2 and TLR4 and influence cytokine production in epithelial cells and macrophages. Current insight suggests that hydrolysates may actively participate in modulating the immune responses in subjects with cow's milk allergy and those at risk to develop cow's milk allergy. However, more research is required to design effective and reproducible means to develop targeting strategies to modulate the immune response." @default.
- W2113011946 created "2016-06-24" @default.
- W2113011946 creator A5002327084 @default.
- W2113011946 creator A5022326223 @default.
- W2113011946 creator A5030773770 @default.
- W2113011946 creator A5050797896 @default.
- W2113011946 creator A5085240928 @default.
- W2113011946 date "2015-04-23" @default.
- W2113011946 modified "2023-09-25" @default.
- W2113011946 title "Immunomodulating properties of protein hydrolysates for application in cow's milk allergy" @default.
- W2113011946 cites W1516875724 @default.
- W2113011946 cites W1535207598 @default.
- W2113011946 cites W1584043088 @default.
- W2113011946 cites W1787326408 @default.
- W2113011946 cites W1866330001 @default.
- W2113011946 cites W1924364868 @default.
- W2113011946 cites W1966413993 @default.
- W2113011946 cites W1967142434 @default.
- W2113011946 cites W1968500106 @default.
- W2113011946 cites W1972433056 @default.
- W2113011946 cites W1974112843 @default.
- W2113011946 cites W1982898080 @default.
- W2113011946 cites W1984172120 @default.
- W2113011946 cites W1988034812 @default.
- W2113011946 cites W1991804457 @default.
- W2113011946 cites W2003257442 @default.
- W2113011946 cites W2005922317 @default.
- W2113011946 cites W2006249161 @default.
- W2113011946 cites W2010388697 @default.
- W2113011946 cites W2012315655 @default.
- W2113011946 cites W2013583078 @default.
- W2113011946 cites W2018247592 @default.
- W2113011946 cites W2020478376 @default.
- W2113011946 cites W2022438138 @default.
- W2113011946 cites W2025114863 @default.
- W2113011946 cites W2025807550 @default.
- W2113011946 cites W2026804563 @default.
- W2113011946 cites W2027276339 @default.
- W2113011946 cites W2028000219 @default.
- W2113011946 cites W2033982089 @default.
- W2113011946 cites W2034766312 @default.
- W2113011946 cites W2046807592 @default.
- W2113011946 cites W2053434346 @default.
- W2113011946 cites W2055959752 @default.
- W2113011946 cites W2057121293 @default.
- W2113011946 cites W2065580366 @default.
- W2113011946 cites W2067451270 @default.
- W2113011946 cites W2067916951 @default.
- W2113011946 cites W2069609837 @default.
- W2113011946 cites W2069715471 @default.
- W2113011946 cites W2070689302 @default.
- W2113011946 cites W2081595143 @default.
- W2113011946 cites W2082732215 @default.
- W2113011946 cites W2083928235 @default.
- W2113011946 cites W2084231086 @default.
- W2113011946 cites W2087251699 @default.
- W2113011946 cites W2087594137 @default.
- W2113011946 cites W2090095459 @default.
- W2113011946 cites W2094771034 @default.
- W2113011946 cites W2096015727 @default.
- W2113011946 cites W2098011343 @default.
- W2113011946 cites W2105176378 @default.
- W2113011946 cites W2107066107 @default.
- W2113011946 cites W2111481848 @default.
- W2113011946 cites W2122402618 @default.
- W2113011946 cites W2127121503 @default.
- W2113011946 cites W2136848239 @default.
- W2113011946 cites W2147566306 @default.
- W2113011946 cites W2156868373 @default.
- W2113011946 cites W2160950452 @default.
- W2113011946 cites W2164098277 @default.
- W2113011946 cites W2169650544 @default.
- W2113011946 cites W2315679175 @default.
- W2113011946 cites W2323872836 @default.
- W2113011946 cites W4205870591 @default.
- W2113011946 cites W4211035899 @default.
- W2113011946 doi "https://doi.org/10.1111/pai.12354" @default.
- W2113011946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25692325" @default.
- W2113011946 hasPublicationYear "2015" @default.
- W2113011946 type Work @default.
- W2113011946 sameAs 2113011946 @default.
- W2113011946 citedByCount "33" @default.
- W2113011946 countsByYear W21130119462015 @default.
- W2113011946 countsByYear W21130119462017 @default.
- W2113011946 countsByYear W21130119462018 @default.
- W2113011946 countsByYear W21130119462019 @default.
- W2113011946 countsByYear W21130119462020 @default.
- W2113011946 countsByYear W21130119462021 @default.
- W2113011946 countsByYear W21130119462022 @default.
- W2113011946 countsByYear W21130119462023 @default.
- W2113011946 crossrefType "journal-article" @default.
- W2113011946 hasAuthorship W2113011946A5002327084 @default.
- W2113011946 hasAuthorship W2113011946A5022326223 @default.
- W2113011946 hasAuthorship W2113011946A5030773770 @default.
- W2113011946 hasAuthorship W2113011946A5050797896 @default.
- W2113011946 hasAuthorship W2113011946A5085240928 @default.
- W2113011946 hasConcept C147483822 @default.
- W2113011946 hasConcept C203014093 @default.