FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113012500> ?p ?o ?g. }

• W2113012500 endingPage "221" @default.
• W2113012500 startingPage "211" @default.
• W2113012500 abstract "Abstract The cytochrome P450 aromatase ( Cyp19 ) gene encodes an enzyme of crucial importance in the synthesis of estradiol. Estradiol is luteotropic in the rat. In this species, luteal Cyp19 expression increases progressively during pregnancy and falls before parturition. The mechanisms that control these changes are unknown. Using gel shift assays, we sought to identify the promoter regions that control Cyp19 expression in the rat corpus luteum (CL). The Cyp19 promoter contains a cAMP response element-like sequence (CLS), two nuclear receptor elements half sites (NREs), a GATA binding site, a Yin Yang-1 (YY1) response element, and an activation protein 3 (AP3) binding site. Nuclear extracts were obtained from CL of rats on days 4, 15, and 23 of pregnancy and from the ovaries of immature rats treated with vehicle or a hormone that induces Cyp19 expression in the follicles. CLS was active in immature ovaries but inactive in the CL of pregnant rats, whereas binding to NREs and GATA was observed in both tissues. YY1 was inactive in all samples tested. In the CL, AP3 binding was higher on day 15 of pregnancy when compared with day 4 and day 23 but it was absent in ovaries of immature rats, whereas luteinization increased AP3 binding activity. Mutation of the AP3 site blunted the stimulation of Cyp19 promoter activity in granulosa cells. Our results indicate that CLS is active only in follicles; whereas in the CL, binding to the GATA, NRE, and AP3 sites associates with changes in Cyp19 expression, suggesting that they control Cyp19 promoter activity in luteal cells." @default.
• W2113012500 created "2016-06-24" @default.
• W2113012500 creator A5008672669 @default.
• W2113012500 creator A5031211519 @default.
• W2113012500 creator A5089639451 @default.
• W2113012500 date "2007-10-01" @default.
• W2113012500 modified "2023-09-28" @default.
• W2113012500 title "Identification of regulatory elements in the Cyp19 proximal promoter in rat luteal cells" @default.
• W2113012500 cites W1607881510 @default.
• W2113012500 cites W1859862271 @default.
• W2113012500 cites W1968244375 @default.
• W2113012500 cites W1973252220 @default.
• W2113012500 cites W1976989509 @default.
• W2113012500 cites W1979077762 @default.
• W2113012500 cites W1990570329 @default.
• W2113012500 cites W1997676769 @default.
• W2113012500 cites W2000200086 @default.
• W2113012500 cites W2011952922 @default.
• W2113012500 cites W2019471411 @default.
• W2113012500 cites W2020919421 @default.
• W2113012500 cites W2021404668 @default.
• W2113012500 cites W2035993965 @default.
• W2113012500 cites W2040279811 @default.
• W2113012500 cites W2042941910 @default.
• W2113012500 cites W2048646391 @default.
• W2113012500 cites W2061776830 @default.
• W2113012500 cites W2062081970 @default.
• W2113012500 cites W2066374865 @default.
• W2113012500 cites W2069998560 @default.
• W2113012500 cites W2073970692 @default.
• W2113012500 cites W2077213568 @default.
• W2113012500 cites W2082496903 @default.
• W2113012500 cites W2082717337 @default.
• W2113012500 cites W2082807027 @default.
• W2113012500 cites W2083869788 @default.
• W2113012500 cites W2086650080 @default.
• W2113012500 cites W2088681111 @default.
• W2113012500 cites W2088970294 @default.
• W2113012500 cites W2092120029 @default.
• W2113012500 cites W2093401993 @default.
• W2113012500 cites W2095719571 @default.
• W2113012500 cites W2108551371 @default.
• W2113012500 cites W2117887814 @default.
• W2113012500 cites W2125886819 @default.
• W2113012500 cites W2126100083 @default.
• W2113012500 cites W2128048967 @default.
• W2113012500 cites W2136949042 @default.
• W2113012500 cites W2138158343 @default.
• W2113012500 cites W2145431540 @default.
• W2113012500 cites W2147196233 @default.
• W2113012500 cites W2160353038 @default.
• W2113012500 cites W2227136145 @default.
• W2113012500 doi "https://doi.org/10.1677/jme-07-0026" @default.
• W2113012500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17909262" @default.
• W2113012500 hasPublicationYear "2007" @default.
• W2113012500 type Work @default.
• W2113012500 sameAs 2113012500 @default.
• W2113012500 citedByCount "23" @default.
• W2113012500 countsByYear W21130125002012 @default.
• W2113012500 countsByYear W21130125002014 @default.
• W2113012500 countsByYear W21130125002015 @default.
• W2113012500 countsByYear W21130125002016 @default.
• W2113012500 countsByYear W21130125002017 @default.
• W2113012500 countsByYear W21130125002019 @default.
• W2113012500 countsByYear W21130125002021 @default.
• W2113012500 countsByYear W21130125002022 @default.
• W2113012500 crossrefType "journal-article" @default.
• W2113012500 hasAuthorship W2113012500A5008672669 @default.
• W2113012500 hasAuthorship W2113012500A5031211519 @default.
• W2113012500 hasAuthorship W2113012500A5089639451 @default.
• W2113012500 hasBestOaLocation W21130125001 @default.
• W2113012500 hasConcept C101762097 @default.
• W2113012500 hasConcept C104317684 @default.
• W2113012500 hasConcept C107824862 @default.
• W2113012500 hasConcept C121608353 @default.
• W2113012500 hasConcept C126322002 @default.
• W2113012500 hasConcept C132376346 @default.
• W2113012500 hasConcept C134018914 @default.
• W2113012500 hasConcept C143228043 @default.
• W2113012500 hasConcept C150194340 @default.
• W2113012500 hasConcept C153911025 @default.
• W2113012500 hasConcept C185592680 @default.
• W2113012500 hasConcept C2776166826 @default.
• W2113012500 hasConcept C2776608385 @default.
• W2113012500 hasConcept C2778324911 @default.
• W2113012500 hasConcept C530470458 @default.
• W2113012500 hasConcept C55493867 @default.
• W2113012500 hasConcept C71315377 @default.
• W2113012500 hasConcept C71924100 @default.
• W2113012500 hasConcept C86803240 @default.
• W2113012500 hasConceptScore W2113012500C101762097 @default.
• W2113012500 hasConceptScore W2113012500C104317684 @default.
• W2113012500 hasConceptScore W2113012500C107824862 @default.
• W2113012500 hasConceptScore W2113012500C121608353 @default.
• W2113012500 hasConceptScore W2113012500C126322002 @default.
• W2113012500 hasConceptScore W2113012500C132376346 @default.
• W2113012500 hasConceptScore W2113012500C134018914 @default.
• W2113012500 hasConceptScore W2113012500C143228043 @default.

• next