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• W2113012829 endingPage "1291" @default.
• W2113012829 startingPage "1270" @default.
• W2113012829 abstract "We recently characterized physiologically a pontine reticulospinal (pRS) projection in the neonatal mouse that mediates synaptic effects on spinal motoneurons via parallel uncrossed and crossed pathways (Sivertsen et al. [2014] J Neurophysiol 112:1628-1643). Here we characterize the origins, anatomical organization, and supraspinal axon trajectories of these pathways via retrograde tracing from the high cervical spinal cord. The two pathways derive from segregated populations of ipsilaterally and contralaterally projecting pRS neurons with characteristic locations within the pontine reticular formation (PRF). We obtained estimates of relative neuron numbers by counting from sections, digitally generated neuron position maps, and 3D reconstructions. Ipsilateral pRS neurons outnumber contralateral pRS neurons by threefold and are distributed about equally in rostral and caudal regions of the PRF, whereas contralateral pRS neurons are concentrated in the rostral PRF. Ipsilateral pRS neuron somata are on average larger than contralateral. No pRS neurons are positive in transgenic mice that report the expression of GAD, suggesting that they are predominantly excitatory. Putative GABAergic interneurons are interspersed among the pRS neurons, however. Ipsilateral and contralateral pRS axons have distinctly different trajectories within the brainstem. Their initial spinal funicular trajectories also differ, with ipsilateral and contralateral pRS axons more highly concentrated medially and laterally, respectively. The larger size and greater number of ipsilateral vs. contralateral pRS neurons is compatible with our previous finding that the uncrossed projection transmits more reliably to spinal motoneurons. The information about supraspinal and initial spinal pRS axon trajectories should facilitate future physiological assessment of synaptic connections between pRS neurons and spinal neurons." @default.
• W2113012829 created "2016-06-24" @default.
• W2113012829 creator A5003593380 @default.
• W2113012829 creator A5052454516 @default.
• W2113012829 creator A5083471545 @default.
• W2113012829 date "2015-10-10" @default.
• W2113012829 modified "2023-10-16" @default.
• W2113012829 title "Pontine reticulospinal projections in the neonatal mouse: Internal organization and axon trajectories" @default.
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• W2113012829 doi "https://doi.org/10.1002/cne.23904" @default.
• W2113012829 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4851107" @default.
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• W2113012829 hasPublicationYear "2015" @default.
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