FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113014090> ?p ?o ?g. }

• W2113014090 endingPage "42" @default.
• W2113014090 startingPage "42" @default.
• W2113014090 abstract "Human hookworm infection is a major cause of anemia and malnutrition of adults and children in the developing world. As part of on-going efforts to control hookworm infection, The Human Hookworm Vaccine Initiative has identified candidate vaccine antigens from the infective L3 larval stages and adult stages of the parasite. Adult stage antigens include the cytosolic glutathione-S-transferases (GSTs). Nematode GSTs facilitate the inactivation and degradation of a variety of electrophilic substrates (drugs) via the nucleophilic addition of reduced glutathione. Parasite GSTs also play significant roles in multi-drug resistance and the modulation of host-immune defense mechanisms.The crystal structures of Na-GST-1 and Na-GST-2, two major GSTs from Necator americanus the main human hookworm parasite, have been solved at the resolution limits of 2.4 A and 1.9 A respectively. The structure of Na-GST-1 was refined to R-factor 18.9% (R-free 28.3%) while that of Na-GST-2 was refined to R-factor 17.1% (R-free 21.7%). Glutathione usurped during the fermentation process in bound in the glutathione binding site (G-site) of each monomer of Na-GST-2. Na-GST-1 is uncomplexed and its G-site is abrogated by Gln 50. These first structures of human hookworm parasite GSTs could aid the design of novel hookworm drugs.The 3-dimensional structures of Na-GST-1 and Na-GST-2 show two views of human hookworm GSTs. While the GST-complex structure of Na-GST-2 reveals a typical GST G-site that of Na-GST-1 suggests that there is some conformational flexibility required in order to bind the substrate GST. In addition, the overall binding cavities for both are larger, more open, as well as more accessible to diverse ligands than those of GSTs from organisms that have other major detoxifying mechanisms. The results from this study could aid in the design of novel drugs and vaccine antigens." @default.
• W2113014090 created "2016-06-24" @default.
• W2113014090 creator A5000045167 @default.
• W2113014090 creator A5003252558 @default.
• W2113014090 creator A5014905711 @default.
• W2113014090 creator A5020411177 @default.
• W2113014090 creator A5037992638 @default.
• W2113014090 creator A5038522588 @default.
• W2113014090 creator A5039341329 @default.
• W2113014090 creator A5087704375 @default.
• W2113014090 date "2007-01-01" @default.
• W2113014090 modified "2023-09-27" @default.
• W2113014090 title "X-ray structures of Na-GST-1 and Na-GST-2 two glutathione s-transferase from the human hookworm Necator americanus" @default.
• W2113014090 cites W1439017644 @default.
• W2113014090 cites W1535254030 @default.
• W2113014090 cites W1544393038 @default.
• W2113014090 cites W1658183808 @default.
• W2113014090 cites W1975838671 @default.
• W2113014090 cites W1982616575 @default.
• W2113014090 cites W1983004272 @default.
• W2113014090 cites W1985629904 @default.
• W2113014090 cites W1985836097 @default.
• W2113014090 cites W1994286350 @default.
• W2113014090 cites W1996607909 @default.
• W2113014090 cites W1999590520 @default.
• W2113014090 cites W2003939815 @default.
• W2113014090 cites W2009439501 @default.
• W2113014090 cites W2010089611 @default.
• W2113014090 cites W2011374678 @default.
• W2113014090 cites W2013083986 @default.
• W2113014090 cites W2015170436 @default.
• W2113014090 cites W2015461045 @default.
• W2113014090 cites W2016330738 @default.
• W2113014090 cites W2016765195 @default.
• W2113014090 cites W2019977862 @default.
• W2113014090 cites W2025089555 @default.
• W2113014090 cites W2038840577 @default.
• W2113014090 cites W2044140180 @default.
• W2113014090 cites W2045225511 @default.
• W2113014090 cites W2053310200 @default.
• W2113014090 cites W2060078710 @default.
• W2113014090 cites W2060809301 @default.
• W2113014090 cites W2075356247 @default.
• W2113014090 cites W2088686292 @default.
• W2113014090 cites W2094441174 @default.
• W2113014090 cites W2102201378 @default.
• W2113014090 cites W2106141725 @default.
• W2113014090 cites W2110893691 @default.
• W2113014090 cites W2116947993 @default.
• W2113014090 cites W2133006527 @default.
• W2113014090 cites W2135632270 @default.
• W2113014090 cites W2144860058 @default.
• W2113014090 cites W2147836597 @default.
• W2113014090 cites W2150559054 @default.
• W2113014090 cites W2151473667 @default.
• W2113014090 cites W2154922304 @default.
• W2113014090 cites W2156188380 @default.
• W2113014090 cites W2157052957 @default.
• W2113014090 cites W2157256199 @default.
• W2113014090 cites W2160695434 @default.
• W2113014090 cites W2218053556 @default.
• W2113014090 cites W2340400496 @default.
• W2113014090 cites W2409413906 @default.
• W2113014090 cites W317728824 @default.
• W2113014090 cites W4234297355 @default.
• W2113014090 cites W4242482565 @default.
• W2113014090 cites W4249342053 @default.
• W2113014090 doi "https://doi.org/10.1186/1472-6807-7-42" @default.
• W2113014090 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1924862" @default.
• W2113014090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17594497" @default.
• W2113014090 hasPublicationYear "2007" @default.
• W2113014090 type Work @default.
• W2113014090 sameAs 2113014090 @default.
• W2113014090 citedByCount "39" @default.
• W2113014090 countsByYear W21130140902012 @default.
• W2113014090 countsByYear W21130140902013 @default.
• W2113014090 countsByYear W21130140902014 @default.
• W2113014090 countsByYear W21130140902016 @default.
• W2113014090 countsByYear W21130140902017 @default.
• W2113014090 countsByYear W21130140902018 @default.
• W2113014090 countsByYear W21130140902020 @default.
• W2113014090 countsByYear W21130140902021 @default.
• W2113014090 countsByYear W21130140902022 @default.
• W2113014090 countsByYear W21130140902023 @default.
• W2113014090 crossrefType "journal-article" @default.
• W2113014090 hasAuthorship W2113014090A5000045167 @default.
• W2113014090 hasAuthorship W2113014090A5003252558 @default.
• W2113014090 hasAuthorship W2113014090A5014905711 @default.
• W2113014090 hasAuthorship W2113014090A5020411177 @default.
• W2113014090 hasAuthorship W2113014090A5037992638 @default.
• W2113014090 hasAuthorship W2113014090A5038522588 @default.
• W2113014090 hasAuthorship W2113014090A5039341329 @default.
• W2113014090 hasAuthorship W2113014090A5087704375 @default.
• W2113014090 hasBestOaLocation W21130140901 @default.
• W2113014090 hasConcept C147483822 @default.
• W2113014090 hasConcept C165901193 @default.
• W2113014090 hasConcept C181199279 @default.
• W2113014090 hasConcept C203014093 @default.

• next