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• W2113014475 abstract "<h3>Abstract</h3> Patients with hematological malignancies are prioritized for COVID-19 vaccine due to their high risk for severe SARS-CoV-2 infection related disease and mortality. To understand T cell immunity, its long-term persistence, and correlation with antibody response, we evaluated the BNT162b2 COVID-19 mRNA vaccine-specific immune response in chronic lymphocytic leukemia (CLL) and myeloid dysplastic syndrome (MDS) patients. Longitudinal analysis of CD8⁺ T cells using DNA-barcoded peptide-MHC multimers covering the full SARS-CoV-2 Spike-protein (415 peptides) showed vaccine-specific T cell activation and persistence of memory T cells up to six months post-vaccination. Surprisingly, a higher frequency of vaccine-induced antigen-specific CD8⁺ T cell was observed in the patient group compared to a healthy donor group. Furthermore, and importantly, immunization with the second booster dose significantly increased the frequency of antigen-specific CD8⁺ T cells as well as the total number of T cell specificities. Altogether 59 BNT162b2 vaccine-derived immunogenic epitopes were identified, of which 23 established long-term CD8⁺ T cell memory response with a strong immunodominance for NYNYLYRLF (HLA-A24:02) and YLQPRTFLL (HLA-A02:01) epitopes. In summary, we mapped the vaccine-induced antigen-specific CD8⁺ T cells and showed a booster-specific activation and enrichment of memory T cells that could be important for long-term disease protection in this patient group. <h3>Key Points</h3> COVID-19 mRNA vaccine induced an early and persistent activation of antigen-specific CD8⁺ T cells in this patient group. Vaccination with a booster dose is required to maintain vaccine-specific CD8⁺ T cells." @default.
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• W2113014475 date "2012-12-13" @default.
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• W2113014475 title "Inhibition of spleen tyrosine kinase as treatment of postoperative ileus" @default.
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• W2113014475 doi "https://doi.org/10.1136/gutjnl-2012-302615" @default.
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