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• W2113016023 abstract "Extended depth of field (EDF) microscopy, achieved through computational optics, allows for real-time 3D imaging of live cell dynamics. EDF is achieved through a combination of point spread function engineering and digital image processing. A linear Wiener filter has been conventionally used to deconvolve the image, but it suffers from high frequency noise amplification and processing artifacts. A nonlinear processing scheme is proposed which extends the depth of field while minimizing background noise. The nonlinear filter is generated via a training algorithm and an iterative optimizer. Biological microscope images processed with the nonlinear filter show a significant improvement in image quality and signal-to-noise ratio over the conventional linear filter." @default.
• W2113016023 created "2016-06-24" @default.
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• W2113016023 date "2013-03-11" @default.
• W2113016023 modified "2023-10-14" @default.
• W2113016023 title "Noise removal in extended depth of field microscope images through nonlinear signal processing" @default.
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• W2113016023 doi "https://doi.org/10.1364/ao.52.0000d1" @default.
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