Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113017980> ?p ?o ?g. }
- W2113017980 endingPage "75" @default.
- W2113017980 startingPage "65" @default.
- W2113017980 abstract "The dopamine D4 receptor (DRD4) is the most important gene in psychiatric genetics since its involvement in the physiology of behavior, pharmacology response and psychopathology. DRD4's sequence gene present some polymorphism such as in the exon 3 constituted from 2 to 10 copies of repetitive sequences of 48 base pair (bp), from class variable number tandem repeats (VNTR). An additional genetic variant in the exon 1 presents polymorphisms to 12 bp VNTR, and the variation -521 C by T of the promoter region. The -521 T allele can reduce the efficiency of the gene expression in comparison with the C allele. The DRD4 gene codes a protein transmembranal of 7 domains, distributed in front cortex, striatum, hypothalamus and hippocampus. This review discusses the biological significance of DRD4 gene and its perspective with emphasis on the impact of association studies in some illness mental and behavioral traits. The DRD4 polymorphism has been studied in association with illnesses like schizophrenia, attention deficit hyperactivity disorder (ADHD), obsessive-compulsive with tics, bipolar manic-depressive disorder, in addition behavioral traits such as novelty seeking. The DRD4 gene is a genetic marker that could play a role in etiology of different mental illness, and behavioral traits, and its polymorphism can be used in association studies, epigenetic and pharmacogenomic analysis for help to understand the genetics basis of both mental disorders and traits." @default.
- W2113017980 created "2016-06-24" @default.
- W2113017980 creator A5028287374 @default.
- W2113017980 creator A5043866075 @default.
- W2113017980 date "2005-06-29" @default.
- W2113017980 modified "2023-09-23" @default.
- W2113017980 title "[DRD4 polymorphism and the association with mental disorders]." @default.
- W2113017980 cites W130947350 @default.
- W2113017980 cites W163504149 @default.
- W2113017980 cites W1964057706 @default.
- W2113017980 cites W1966745635 @default.
- W2113017980 cites W1971671044 @default.
- W2113017980 cites W1973118113 @default.
- W2113017980 cites W1973678939 @default.
- W2113017980 cites W1975590817 @default.
- W2113017980 cites W1977375680 @default.
- W2113017980 cites W1979581644 @default.
- W2113017980 cites W1991189774 @default.
- W2113017980 cites W1991965466 @default.
- W2113017980 cites W1997914870 @default.
- W2113017980 cites W2001515224 @default.
- W2113017980 cites W2003882735 @default.
- W2113017980 cites W2008047653 @default.
- W2113017980 cites W2009920684 @default.
- W2113017980 cites W2022486591 @default.
- W2113017980 cites W2024054703 @default.
- W2113017980 cites W2026395566 @default.
- W2113017980 cites W2030905853 @default.
- W2113017980 cites W2040133201 @default.
- W2113017980 cites W2046774478 @default.
- W2113017980 cites W2047320236 @default.
- W2113017980 cites W2053529553 @default.
- W2113017980 cites W2054251181 @default.
- W2113017980 cites W2056866499 @default.
- W2113017980 cites W2059230444 @default.
- W2113017980 cites W2065034964 @default.
- W2113017980 cites W2074423743 @default.
- W2113017980 cites W2077291675 @default.
- W2113017980 cites W2080845329 @default.
- W2113017980 cites W2083299361 @default.
- W2113017980 cites W2086707501 @default.
- W2113017980 cites W2091447278 @default.
- W2113017980 cites W2093566021 @default.
- W2113017980 cites W2105400917 @default.
- W2113017980 cites W2113918287 @default.
- W2113017980 cites W2115543229 @default.
- W2113017980 cites W2120483845 @default.
- W2113017980 cites W2120981636 @default.
- W2113017980 cites W2126701473 @default.
- W2113017980 cites W2128254658 @default.
- W2113017980 cites W2142925705 @default.
- W2113017980 cites W2162865128 @default.
- W2113017980 cites W2164478468 @default.
- W2113017980 cites W2311350462 @default.
- W2113017980 cites W2341649589 @default.
- W2113017980 cites W2391961436 @default.
- W2113017980 cites W2419289533 @default.
- W2113017980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15981960" @default.
- W2113017980 hasPublicationYear "2005" @default.
- W2113017980 type Work @default.
- W2113017980 sameAs 2113017980 @default.
- W2113017980 citedByCount "4" @default.
- W2113017980 countsByYear W21130179802015 @default.
- W2113017980 countsByYear W21130179802023 @default.
- W2113017980 crossrefType "journal-article" @default.
- W2113017980 hasAuthorship W2113017980A5028287374 @default.
- W2113017980 hasAuthorship W2113017980A5043866075 @default.
- W2113017980 hasConcept C104317684 @default.
- W2113017980 hasConcept C118552586 @default.
- W2113017980 hasConcept C135763542 @default.
- W2113017980 hasConcept C153209595 @default.
- W2113017980 hasConcept C15744967 @default.
- W2113017980 hasConcept C169900460 @default.
- W2113017980 hasConcept C180754005 @default.
- W2113017980 hasConcept C186413461 @default.
- W2113017980 hasConcept C187288502 @default.
- W2113017980 hasConcept C2776174506 @default.
- W2113017980 hasConcept C2776529864 @default.
- W2113017980 hasConcept C54355233 @default.
- W2113017980 hasConcept C61644593 @default.
- W2113017980 hasConcept C71924100 @default.
- W2113017980 hasConcept C77805123 @default.
- W2113017980 hasConcept C86803240 @default.
- W2113017980 hasConceptScore W2113017980C104317684 @default.
- W2113017980 hasConceptScore W2113017980C118552586 @default.
- W2113017980 hasConceptScore W2113017980C135763542 @default.
- W2113017980 hasConceptScore W2113017980C153209595 @default.
- W2113017980 hasConceptScore W2113017980C15744967 @default.
- W2113017980 hasConceptScore W2113017980C169900460 @default.
- W2113017980 hasConceptScore W2113017980C180754005 @default.
- W2113017980 hasConceptScore W2113017980C186413461 @default.
- W2113017980 hasConceptScore W2113017980C187288502 @default.
- W2113017980 hasConceptScore W2113017980C2776174506 @default.
- W2113017980 hasConceptScore W2113017980C2776529864 @default.
- W2113017980 hasConceptScore W2113017980C54355233 @default.
- W2113017980 hasConceptScore W2113017980C61644593 @default.
- W2113017980 hasConceptScore W2113017980C71924100 @default.
- W2113017980 hasConceptScore W2113017980C77805123 @default.