FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113018933> ?p ?o ?g. }

• W2113018933 endingPage "4680" @default.
• W2113018933 startingPage "4673" @default.
• W2113018933 abstract "In the transmissible spongiform encephalopathies, disease is closely associated with the conversion of the normal proteinase K-sensitive host prion protein (PrP-sen) to the abnormal proteinase K-resistant form (PrP-res). Amino acid sequence homology between PrP-res and PrP-sen is important in the formation of new PrP-res and thus in the efficient transmission of infectivity across species barriers. It was previously shown that the generation of mouse PrP-res was strongly influenced by homology between PrP-sen and PrP-res at amino acid residue 138, a residue located in a region of loop structure common to PrP molecules from many different species. In order to determine if homology at residue 138 also affected the formation of PrP-res in a different animal species, we assayed the ability of hamster PrP-res to convert a panel of recombinant PrP-sen molecules to protease-resistant PrP in a cell-free conversion system. Homology at amino acid residue 138 was not critical for the formation of protease-resistant hamster PrP. Rather, homology between PrP-sen and hamster PrP-res at amino acid residue 155 determined the efficiency of formation of a protease-resistant product induced by hamster PrP-res. Structurally, residue 155 resides in a turn at the end of the first alpha helix in hamster PrP-sen; this feature is not present in mouse PrP-sen. Thus, our data suggest that PrP-res molecules isolated from scrapie-infected brains of different animal species have different PrP-sen structural requirements for the efficient formation of protease-resistant PrP." @default.
• W2113018933 created "2016-06-24" @default.
• W2113018933 creator A5026834670 @default.
• W2113018933 creator A5084875829 @default.
• W2113018933 creator A5088551514 @default.
• W2113018933 date "2001-05-15" @default.
• W2113018933 modified "2023-09-25" @default.
• W2113018933 title "Efficient Conversion of Normal Prion Protein (PrP) by Abnormal Hamster PrP Is Determined by Homology at Amino Acid Residue 155" @default.
• W2113018933 cites W1483315850 @default.
• W2113018933 cites W1498054718 @default.
• W2113018933 cites W1556924360 @default.
• W2113018933 cites W1558969742 @default.
• W2113018933 cites W1567267284 @default.
• W2113018933 cites W1601881612 @default.
• W2113018933 cites W1645442091 @default.
• W2113018933 cites W1702780721 @default.
• W2113018933 cites W1784563469 @default.
• W2113018933 cites W1845629226 @default.
• W2113018933 cites W1900471667 @default.
• W2113018933 cites W1968219224 @default.
• W2113018933 cites W1973388039 @default.
• W2113018933 cites W1983750916 @default.
• W2113018933 cites W1986735189 @default.
• W2113018933 cites W1992084965 @default.
• W2113018933 cites W1998038512 @default.
• W2113018933 cites W2003818263 @default.
• W2113018933 cites W2008789887 @default.
• W2113018933 cites W2011108781 @default.
• W2113018933 cites W2013679718 @default.
• W2113018933 cites W2018675827 @default.
• W2113018933 cites W2019748604 @default.
• W2113018933 cites W2021489997 @default.
• W2113018933 cites W2023529808 @default.
• W2113018933 cites W2029428782 @default.
• W2113018933 cites W2042978244 @default.
• W2113018933 cites W2043526072 @default.
• W2113018933 cites W2043979078 @default.
• W2113018933 cites W2048830197 @default.
• W2113018933 cites W2050036217 @default.
• W2113018933 cites W2052601863 @default.
• W2113018933 cites W2053636966 @default.
• W2113018933 cites W2058503712 @default.
• W2113018933 cites W2067536393 @default.
• W2113018933 cites W2076133781 @default.
• W2113018933 cites W2081705989 @default.
• W2113018933 cites W2082573664 @default.
• W2113018933 cites W2083642579 @default.
• W2113018933 cites W2095414734 @default.
• W2113018933 cites W2097484192 @default.
• W2113018933 cites W2099576534 @default.
• W2113018933 cites W2110420813 @default.
• W2113018933 cites W2110946337 @default.
• W2113018933 cites W2121611717 @default.
• W2113018933 cites W2133288158 @default.
• W2113018933 cites W2138498069 @default.
• W2113018933 cites W2143795630 @default.
• W2113018933 cites W2157468951 @default.
• W2113018933 cites W2163612750 @default.
• W2113018933 cites W2165319015 @default.
• W2113018933 cites W2421204664 @default.
• W2113018933 cites W4213026430 @default.
• W2113018933 doi "https://doi.org/10.1128/jvi.75.10.4673-4680.2001" @default.
• W2113018933 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/114221" @default.
• W2113018933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11312338" @default.
• W2113018933 hasPublicationYear "2001" @default.
• W2113018933 type Work @default.
• W2113018933 sameAs 2113018933 @default.
• W2113018933 citedByCount "71" @default.
• W2113018933 countsByYear W21130189332012 @default.
• W2113018933 countsByYear W21130189332013 @default.
• W2113018933 countsByYear W21130189332014 @default.
• W2113018933 countsByYear W21130189332015 @default.
• W2113018933 countsByYear W21130189332017 @default.
• W2113018933 countsByYear W21130189332019 @default.
• W2113018933 countsByYear W21130189332021 @default.
• W2113018933 countsByYear W21130189332022 @default.
• W2113018933 countsByYear W21130189332023 @default.
• W2113018933 crossrefType "journal-article" @default.
• W2113018933 hasAuthorship W2113018933A5026834670 @default.
• W2113018933 hasAuthorship W2113018933A5084875829 @default.
• W2113018933 hasAuthorship W2113018933A5088551514 @default.
• W2113018933 hasBestOaLocation W21130189331 @default.
• W2113018933 hasConcept C104317684 @default.
• W2113018933 hasConcept C142724271 @default.
• W2113018933 hasConcept C153911025 @default.
• W2113018933 hasConcept C165525559 @default.
• W2113018933 hasConcept C167625842 @default.
• W2113018933 hasConcept C169627665 @default.
• W2113018933 hasConcept C181199279 @default.
• W2113018933 hasConcept C2776735649 @default.
• W2113018933 hasConcept C2778575167 @default.
• W2113018933 hasConcept C2779134260 @default.
• W2113018933 hasConcept C2779525107 @default.
• W2113018933 hasConcept C2781338088 @default.
• W2113018933 hasConcept C3019804061 @default.
• W2113018933 hasConcept C515207424 @default.
• W2113018933 hasConcept C55493867 @default.
• W2113018933 hasConcept C71924100 @default.

• next