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- W2113019718 abstract "The calcium ion (Ca2+) serves as an important cellular messenger with spatio-temporally highly dynamic patterns. Not only Ca2+ entering from the plasma membrane but also Ca2+ released from intracellular store sites play crucial roles in neurons as well as in other cell types. The cerebellar Purkinje cell shows a variety of spatio-temporal Ca2+ dynamics in its rich arborization, and the Ca2+ release mechanism mediated by IP3 receptors and ryanodine receptors has been shown to be crucial for the induction of long-term depression, a form of synaptic plasticity, in this neuron. Purkinje cells in a model mouse line of human neurodegenerative disease, spinocerebellar ataxia type 1, showed abnormal Ca2+ release properties, which indicated tight regulation of Ca2+ dynamics in the wild type Purkinje cell. Quantitative analysis of the complex Ca2+ dynamics in the Purkinje cell dendrite is still in progress to elucidate the link between external stimuli and the resultant biochemical changes." @default.
- W2113019718 created "2016-06-24" @default.
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- W2113019718 date "2003-01-01" @default.
- W2113019718 modified "2023-10-05" @default.
- W2113019718 title "Dynamics of calcium and its roles in the dendrite of the cerebellar Purkinje cell" @default.
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- W2113019718 doi "https://doi.org/10.2302/kjm.52.244" @default.
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