FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113019787> ?p ?o ?g. }

• W2113019787 endingPage "F473" @default.
• W2113019787 startingPage "F466" @default.
• W2113019787 abstract "Substance P (SP) binding to neurokinin 1 receptors (NK1R) in the spinal cord reportedly plays an important role in the micturition reflex as well as in nociceptive responses. We therefore investigated the effect of ablation of NK1R-expressing neurons in the spinal cord using saporin, a ribosome-inactivating protein, conjugated with [Sar9, Met (O2)11]SP, a specific ligand of NK1R (SSP-saporin), on the micturition reflex in rats. In female Sprague-Dawley rats, SSP-saporin (1.0 or 1.5 microM) or saporin (1.5 microM) only was injected through an intrathecal catheter implanted at the L6-S1 level of the spinal cord. Three weeks after intrathecal administration of SSP-saporin, NK1R immunoreactivity in lamina I of the spinal cord was significantly reduced, but cystometric parameters in awake rats were not altered. Instillation of capsaicin (15 microM) into the bladder of normal rats induced bladder overactivity. This response to capsaicin was significantly suppressed in SSP-saporin-treated animals. SSP-saporin treatment also decreased c-fos expression in the dorsal horn of the spinal cord induced by instillation of capsaicin into the bladder. These data indicate that NK1R-expressing neurons in the superficial layer of the dorsal horn play an important role in transmission of nociceptive afferent information from the bladder to induce bladder overactivity and spinal c-fos expression elicited by bladder irritation. Toxin-induced damage of NK1R-expressing neurons in the lumbosacral spinal cord may provide an effective modality for treating overactivity and/or nociceptive responses in the bladder without affecting normal micturition." @default.
• W2113019787 created "2016-06-24" @default.
• W2113019787 creator A5020558777 @default.
• W2113019787 creator A5021824454 @default.
• W2113019787 creator A5029453940 @default.
• W2113019787 creator A5045164790 @default.
• W2113019787 creator A5057338410 @default.
• W2113019787 creator A5071522706 @default.
• W2113019787 creator A5076037136 @default.
• W2113019787 creator A5078179672 @default.
• W2113019787 creator A5091264322 @default.
• W2113019787 date "2005-03-01" @default.
• W2113019787 modified "2023-09-27" @default.
• W2113019787 title "Elimination of rat spinal neurons expressing neurokinin 1 receptors reduces bladder overactivity and spinal c-<i>fos</i> expression induced by bladder irritation" @default.
• W2113019787 cites W1603496942 @default.
• W2113019787 cites W1802450118 @default.
• W2113019787 cites W1970085850 @default.
• W2113019787 cites W1974257946 @default.
• W2113019787 cites W1982604228 @default.
• W2113019787 cites W1982999951 @default.
• W2113019787 cites W1989789207 @default.
• W2113019787 cites W1993054130 @default.
• W2113019787 cites W2001814576 @default.
• W2113019787 cites W2002667179 @default.
• W2113019787 cites W2003404396 @default.
• W2113019787 cites W2008262883 @default.
• W2113019787 cites W2018755533 @default.
• W2113019787 cites W2019416837 @default.
• W2113019787 cites W2037877436 @default.
• W2113019787 cites W2039698753 @default.
• W2113019787 cites W2041272952 @default.
• W2113019787 cites W2045898875 @default.
• W2113019787 cites W2046176229 @default.
• W2113019787 cites W2052460472 @default.
• W2113019787 cites W2058425942 @default.
• W2113019787 cites W2059034808 @default.
• W2113019787 cites W2060065903 @default.
• W2113019787 cites W2063926342 @default.
• W2113019787 cites W2064331471 @default.
• W2113019787 cites W2065528225 @default.
• W2113019787 cites W2065704499 @default.
• W2113019787 cites W2080646752 @default.
• W2113019787 cites W2090375349 @default.
• W2113019787 cites W2090537824 @default.
• W2113019787 cites W2095407465 @default.
• W2113019787 cites W2096842237 @default.
• W2113019787 cites W2112201877 @default.
• W2113019787 cites W2121977436 @default.
• W2113019787 cites W2133949491 @default.
• W2113019787 cites W2154769039 @default.
• W2113019787 cites W2167804359 @default.
• W2113019787 cites W2278556191 @default.
• W2113019787 cites W2403336838 @default.
• W2113019787 cites W2414441021 @default.
• W2113019787 cites W2126933488 @default.
• W2113019787 doi "https://doi.org/10.1152/ajprenal.00274.2004" @default.
• W2113019787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15692058" @default.
• W2113019787 hasPublicationYear "2005" @default.
• W2113019787 type Work @default.
• W2113019787 sameAs 2113019787 @default.
• W2113019787 citedByCount "45" @default.
• W2113019787 countsByYear W21130197872012 @default.
• W2113019787 countsByYear W21130197872013 @default.
• W2113019787 countsByYear W21130197872014 @default.
• W2113019787 countsByYear W21130197872015 @default.
• W2113019787 countsByYear W21130197872016 @default.
• W2113019787 countsByYear W21130197872017 @default.
• W2113019787 countsByYear W21130197872018 @default.
• W2113019787 countsByYear W21130197872020 @default.
• W2113019787 countsByYear W21130197872022 @default.
• W2113019787 countsByYear W21130197872023 @default.
• W2113019787 crossrefType "journal-article" @default.
• W2113019787 hasAuthorship W2113019787A5020558777 @default.
• W2113019787 hasAuthorship W2113019787A5021824454 @default.
• W2113019787 hasAuthorship W2113019787A5029453940 @default.
• W2113019787 hasAuthorship W2113019787A5045164790 @default.
• W2113019787 hasAuthorship W2113019787A5057338410 @default.
• W2113019787 hasAuthorship W2113019787A5071522706 @default.
• W2113019787 hasAuthorship W2113019787A5076037136 @default.
• W2113019787 hasAuthorship W2113019787A5078179672 @default.
• W2113019787 hasAuthorship W2113019787A5091264322 @default.
• W2113019787 hasConcept C115085202 @default.
• W2113019787 hasConcept C118303440 @default.
• W2113019787 hasConcept C118552586 @default.
• W2113019787 hasConcept C126322002 @default.
• W2113019787 hasConcept C134018914 @default.
• W2113019787 hasConcept C15490471 @default.
• W2113019787 hasConcept C155164980 @default.
• W2113019787 hasConcept C159654299 @default.
• W2113019787 hasConcept C160145004 @default.
• W2113019787 hasConcept C170493617 @default.
• W2113019787 hasConcept C175768497 @default.
• W2113019787 hasConcept C185592680 @default.
• W2113019787 hasConcept C203014093 @default.
• W2113019787 hasConcept C2776354303 @default.
• W2113019787 hasConcept C2776533618 @default.
• W2113019787 hasConcept C2780051329 @default.
• W2113019787 hasConcept C2780775167 @default.

• next