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• W2113031567 endingPage "868" @default.
• W2113031567 startingPage "861" @default.
• W2113031567 abstract "CD8(+) T cells (T(CD8+)) can mediate protective immunity to intracellular pathogens and tumours. Viruses generate strong T(CD8+) responses and, therefore, represent attractive vectors for generating vaccines aimed at producing T(CD8+)-mediated protective immunity. This review will examine the immunological properties of viruses that make them good candidates as vaccine vectors, as well as the manipulations of both vector and antigen that may be required to produce an effective vaccine. The areas addressed include virus infection of dendritic cells in vivo, stimulation of the innate immune response via intracellular and extracellular pattern recognition receptors, the effect of antigenic form on the pathways of antigen presentation and the requirement for elimination of viral genes that target various aspects of the innate and adaptive immune response." @default.
• W2113031567 created "2016-06-24" @default.
• W2113031567 creator A5030688459 @default.
• W2113031567 creator A5035678578 @default.
• W2113031567 date "2004-06-01" @default.
• W2113031567 modified "2023-09-27" @default.
• W2113031567 title "Viral vectors for inducing CD8⁺T cell responses" @default.
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• W2113031567 doi "https://doi.org/10.1517/14712598.4.6.861" @default.
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