FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113046139> ?p ?o ?g. }

• W2113046139 endingPage "1142" @default.
• W2113046139 startingPage "1133" @default.
• W2113046139 abstract "Summary. Background: Venous thromboembolism (VTE) is highly heritable (estimated heritability [h2] = 0.62) and likely to be a result of multigenic action. Objective: To systematically test variation within genes encoding for important components of the anticoagulant, procoagulant, fibrinolytic and innate immunity pathways for an independent association with VTE. Methods: Non-Hispanic adults of European ancestry with objectively-diagnosed VTE, and age- and sex- matched controls, were genotyped for 13 031 single nucleotide polymorphisms (SNPs) within 764 genes. Analyses (n = 12 296 SNPs) were performed with plink using an additive genetic model and adjusted for age, sex, state of residence, and myocardial infarction or stroke. Results: Among 2927 individuals, one or more SNPs within ABO, F2, F5, F11, KLKB1, SELP and SCUBE1 were significantly associated with VTE, including factor (F) V Leiden, prothrombin G20210A, ABO non-O blood type, and a novel association with ABO rs2519093 (OR = 1.68, P-value = 8.08 × 10−16) that was independent of blood type. In stratified analyses, SNPs in the following genes were significantly associated with VTE: F5 and ABO among both genders and LY86 among women; F2, ABO and KLKB1 among FV Leiden non-carriers; F5, F11, KLKB1 and GFRA1 in those with ABO non-O blood type; and ABO, F5, F11, KLKB1, SCUBE1 and SELP among prothrombin G20210A non-carriers. The ABO rs2519093 population-attributable risk (PAR) exceeded that of FV Leiden and prothrombin G20210A, and the joint PAR of FV Leiden, prothrombin G20210A, ABO non-O and ABO rs2519093 was 0.40. Conclusions: Anticoagulant, procoagulant, fibrinolytic and innate immunity pathway genetic variation accounts for a large proportion of VTE among non-Hispanic adults of European ancestry." @default.
• W2113046139 created "2016-06-24" @default.
• W2113046139 creator A5002442157 @default.
• W2113046139 creator A5038946006 @default.
• W2113046139 creator A5060283511 @default.
• W2113046139 creator A5065226426 @default.
• W2113046139 creator A5073000523 @default.
• W2113046139 creator A5087317870 @default.
• W2113046139 date "2011-06-01" @default.
• W2113046139 modified "2023-10-17" @default.
• W2113046139 title "Genetic variation within the anticoagulant, procoagulant, fibrinolytic and innate immunity pathways as risk factors for venous thromboembolism" @default.
• W2113046139 cites W1536015903 @default.
• W2113046139 cites W1604340849 @default.
• W2113046139 cites W1696693741 @default.
• W2113046139 cites W1964895626 @default.
• W2113046139 cites W1966026137 @default.
• W2113046139 cites W1966853009 @default.
• W2113046139 cites W1969608698 @default.
• W2113046139 cites W1988013407 @default.
• W2113046139 cites W1988022366 @default.
• W2113046139 cites W1988437478 @default.
• W2113046139 cites W1988456469 @default.
• W2113046139 cites W1988789324 @default.
• W2113046139 cites W1995399604 @default.
• W2113046139 cites W1996072554 @default.
• W2113046139 cites W1998327889 @default.
• W2113046139 cites W2003665776 @default.
• W2113046139 cites W2008104098 @default.
• W2113046139 cites W2015408724 @default.
• W2113046139 cites W2015643243 @default.
• W2113046139 cites W2025128165 @default.
• W2113046139 cites W2032884716 @default.
• W2113046139 cites W2035481781 @default.
• W2113046139 cites W2036655503 @default.
• W2113046139 cites W2038073973 @default.
• W2113046139 cites W2039608769 @default.
• W2113046139 cites W2041393320 @default.
• W2113046139 cites W2055069441 @default.
• W2113046139 cites W2061880868 @default.
• W2113046139 cites W2064491398 @default.
• W2113046139 cites W2068649087 @default.
• W2113046139 cites W2069166171 @default.
• W2113046139 cites W2073405777 @default.
• W2113046139 cites W2077119068 @default.
• W2113046139 cites W2079944343 @default.
• W2113046139 cites W2082472486 @default.
• W2113046139 cites W2085993015 @default.
• W2113046139 cites W2095057588 @default.
• W2113046139 cites W2095553143 @default.
• W2113046139 cites W2102358757 @default.
• W2113046139 cites W2102926234 @default.
• W2113046139 cites W2125568432 @default.
• W2113046139 cites W2132210313 @default.
• W2113046139 cites W2135158117 @default.
• W2113046139 cites W2136021689 @default.
• W2113046139 cites W2139838505 @default.
• W2113046139 cites W2142809579 @default.
• W2113046139 cites W2145025818 @default.
• W2113046139 cites W2145300800 @default.
• W2113046139 cites W2161630867 @default.
• W2113046139 cites W2161633633 @default.
• W2113046139 cites W2162088713 @default.
• W2113046139 cites W2256786579 @default.
• W2113046139 cites W2417146133 @default.
• W2113046139 doi "https://doi.org/10.1111/j.1538-7836.2011.04272.x" @default.
• W2113046139 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3110632" @default.
• W2113046139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21463476" @default.
• W2113046139 hasPublicationYear "2011" @default.
• W2113046139 type Work @default.
• W2113046139 sameAs 2113046139 @default.
• W2113046139 citedByCount "66" @default.
• W2113046139 countsByYear W21130461392012 @default.
• W2113046139 countsByYear W21130461392013 @default.
• W2113046139 countsByYear W21130461392014 @default.
• W2113046139 countsByYear W21130461392015 @default.
• W2113046139 countsByYear W21130461392016 @default.
• W2113046139 countsByYear W21130461392017 @default.
• W2113046139 countsByYear W21130461392018 @default.
• W2113046139 countsByYear W21130461392019 @default.
• W2113046139 countsByYear W21130461392020 @default.
• W2113046139 countsByYear W21130461392021 @default.
• W2113046139 countsByYear W21130461392022 @default.
• W2113046139 countsByYear W21130461392023 @default.
• W2113046139 crossrefType "journal-article" @default.
• W2113046139 hasAuthorship W2113046139A5002442157 @default.
• W2113046139 hasAuthorship W2113046139A5038946006 @default.
• W2113046139 hasAuthorship W2113046139A5060283511 @default.
• W2113046139 hasAuthorship W2113046139A5065226426 @default.
• W2113046139 hasAuthorship W2113046139A5073000523 @default.
• W2113046139 hasAuthorship W2113046139A5087317870 @default.
• W2113046139 hasBestOaLocation W21130461392 @default.
• W2113046139 hasConcept C104317684 @default.
• W2113046139 hasConcept C126322002 @default.
• W2113046139 hasConcept C135763542 @default.
• W2113046139 hasConcept C153209595 @default.
• W2113046139 hasConcept C176080213 @default.
• W2113046139 hasConcept C203014093 @default.
• W2113046139 hasConcept C2777175894 @default.

• next