Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113050239> ?p ?o ?g. }
- W2113050239 endingPage "1867" @default.
- W2113050239 startingPage "1854" @default.
- W2113050239 abstract "Retrotransposons make up over 40% of the mammalian genome. Some copies are still capable of mobilizing and new insertions promote genetic variation. Several members of the APOBEC3 family of DNA cytosine deaminases function to limit the replication of a variety of retroelements, such as the long-terminal repeat (LTR)-containing MusD and Ty1 elements, and that of the non-LTR retrotransposons, L1 and Alu. However, the APOBEC3 genes are limited to mammalian lineages, whereas retrotransposons are far more widespread. This raises the question of what cellular factors control retroelement transposition in species that lack APOBEC3 genes. A strong phylogenetic case can be made that an ancestral activation-induced deaminase (AID)-like gene duplicated and diverged to root the APOBEC3 lineage in mammals. Therefore, we tested the hypothesis that present-day AID proteins possess anti-retroelement activity. We found that AID can inhibit the retrotransposition of L1 through a DNA deamination-independent mechanism. This mechanism may manifest in the cytoplasmic compartment co- or posttranslationally. Together with evidence for AID expression in the ovary, our data combined to suggest that AID has innate immune functions in addition to its integral roles in creating antibody diversity." @default.
- W2113050239 created "2016-06-24" @default.
- W2113050239 creator A5010638373 @default.
- W2113050239 creator A5035901749 @default.
- W2113050239 creator A5046034517 @default.
- W2113050239 date "2009-02-02" @default.
- W2113050239 modified "2023-10-03" @default.
- W2113050239 title "AID can restrict L1 retrotransposition suggesting a dual role in innate and adaptive immunity" @default.
- W2113050239 cites W1480928537 @default.
- W2113050239 cites W1511269200 @default.
- W2113050239 cites W1515277671 @default.
- W2113050239 cites W1557327055 @default.
- W2113050239 cites W1610186027 @default.
- W2113050239 cites W1964538987 @default.
- W2113050239 cites W1965141089 @default.
- W2113050239 cites W1966477735 @default.
- W2113050239 cites W1967215131 @default.
- W2113050239 cites W1968772442 @default.
- W2113050239 cites W1970288540 @default.
- W2113050239 cites W1971400148 @default.
- W2113050239 cites W1990464227 @default.
- W2113050239 cites W1990620891 @default.
- W2113050239 cites W1990993204 @default.
- W2113050239 cites W1991333931 @default.
- W2113050239 cites W1998154426 @default.
- W2113050239 cites W1998238844 @default.
- W2113050239 cites W1998870680 @default.
- W2113050239 cites W1999207703 @default.
- W2113050239 cites W2001375348 @default.
- W2113050239 cites W2002043709 @default.
- W2113050239 cites W2002947836 @default.
- W2113050239 cites W2003574960 @default.
- W2113050239 cites W2006699168 @default.
- W2113050239 cites W2007856011 @default.
- W2113050239 cites W2008782135 @default.
- W2113050239 cites W2011832001 @default.
- W2113050239 cites W2012537642 @default.
- W2113050239 cites W2015820342 @default.
- W2113050239 cites W2016732725 @default.
- W2113050239 cites W2020260318 @default.
- W2113050239 cites W2023035407 @default.
- W2113050239 cites W2029864255 @default.
- W2113050239 cites W2029884547 @default.
- W2113050239 cites W2029930485 @default.
- W2113050239 cites W2032235371 @default.
- W2113050239 cites W2033464993 @default.
- W2113050239 cites W2033631070 @default.
- W2113050239 cites W2035395679 @default.
- W2113050239 cites W2036046527 @default.
- W2113050239 cites W2036374978 @default.
- W2113050239 cites W2036806870 @default.
- W2113050239 cites W2040222685 @default.
- W2113050239 cites W2042797749 @default.
- W2113050239 cites W2046183549 @default.
- W2113050239 cites W2046711617 @default.
- W2113050239 cites W2049725192 @default.
- W2113050239 cites W2049824360 @default.
- W2113050239 cites W2053371575 @default.
- W2113050239 cites W2068653337 @default.
- W2113050239 cites W2068681382 @default.
- W2113050239 cites W2074247685 @default.
- W2113050239 cites W2076441216 @default.
- W2113050239 cites W2080527819 @default.
- W2113050239 cites W2085366207 @default.
- W2113050239 cites W2085758832 @default.
- W2113050239 cites W2091279754 @default.
- W2113050239 cites W2093049412 @default.
- W2113050239 cites W2101039666 @default.
- W2113050239 cites W2107408311 @default.
- W2113050239 cites W2108537480 @default.
- W2113050239 cites W2111079470 @default.
- W2113050239 cites W2112011866 @default.
- W2113050239 cites W2115244435 @default.
- W2113050239 cites W2126192230 @default.
- W2113050239 cites W2129786237 @default.
- W2113050239 cites W2130676809 @default.
- W2113050239 cites W2132196758 @default.
- W2113050239 cites W2134114724 @default.
- W2113050239 cites W2134321611 @default.
- W2113050239 cites W2137015675 @default.
- W2113050239 cites W2138539208 @default.
- W2113050239 cites W2144124481 @default.
- W2113050239 cites W2148047088 @default.
- W2113050239 cites W2148731561 @default.
- W2113050239 cites W2150010396 @default.
- W2113050239 cites W2150649207 @default.
- W2113050239 cites W2151225501 @default.
- W2113050239 cites W2151464048 @default.
- W2113050239 cites W2152480547 @default.
- W2113050239 cites W2153495666 @default.
- W2113050239 cites W2154735764 @default.
- W2113050239 cites W2156839964 @default.
- W2113050239 cites W2159320798 @default.
- W2113050239 cites W2160935824 @default.
- W2113050239 cites W2162649886 @default.
- W2113050239 cites W2165608602 @default.
- W2113050239 cites W2165637925 @default.
- W2113050239 cites W2166512140 @default.