FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113062593> ?p ?o ?g. }

• W2113062593 endingPage "837" @default.
• W2113062593 startingPage "831" @default.
• W2113062593 abstract "Propylisopropylacetic acid (PIA) is a constitutional isomer of valproic acid (VPA). It has previously been found to be a weak antiepileptic, but in common with mood stabilizers, causes inositol depletion and growth cone spreading, suggesting the basis of a new series of mood stabilizers. To assess this possibility, we have compared the effects of racemic (R,S)-PIA and its individual enantiomers to those of the mood stabilizers lithium (Li+), VPA and carbamazepine (CBZ). Unlike Li+ and VPA, but in common with CBZ and (R,S)-PIA, neither (R)-PIA nor (S)-PIA enantiomer induces T-cell factor (TCF)-mediated gene expression. However, as seen for other mood stabilizers, both enantiomers are potent inducers of growth cone spreading. To investigate the mechanism for these effects, we examined changes in the actin cytoskeleton following drug treatment with Li+, VPA, CBZ, (R,S)-PIA or its individual enantiomers. All exhibit a re-distribution of F-actin to the growth cone periphery, a feature of spread growth cones. (R,S)-PIA has the strongest effect as it also elevates F-actin polymerization at the cell periphery. This change in the actin cytoskeleton is associated with a substantial increase in F-actin-rich protrusions on the surface of the growth cone and in its close vicinity. These results demonstrate an effect of (R,S)-PIA on the neuronal actin cytoskeleton shared in common with other mood stabilizers, and suggest a potential to induce structural changes within the CNS." @default.
• W2113062593 created "2016-06-24" @default.
• W2113062593 creator A5001346835 @default.
• W2113062593 creator A5019305436 @default.
• W2113062593 creator A5046756440 @default.
• W2113062593 creator A5060342234 @default.
• W2113062593 creator A5087417185 @default.
• W2113062593 creator A5089448145 @default.
• W2113062593 date "2009-03-01" @default.
• W2113062593 modified "2023-09-27" @default.
• W2113062593 title "Evaluation of the effects of propylisopropylacetic acid (PIA) on neuronal growth cone morphology" @default.
• W2113062593 cites W1693467605 @default.
• W2113062593 cites W1897439129 @default.
• W2113062593 cites W1927894522 @default.
• W2113062593 cites W1966715692 @default.
• W2113062593 cites W1987341255 @default.
• W2113062593 cites W1993796910 @default.
• W2113062593 cites W1995444530 @default.
• W2113062593 cites W1998277289 @default.
• W2113062593 cites W1998772348 @default.
• W2113062593 cites W1999747923 @default.
• W2113062593 cites W2008478586 @default.
• W2113062593 cites W2028494426 @default.
• W2113062593 cites W2030446659 @default.
• W2113062593 cites W2040101760 @default.
• W2113062593 cites W2041226541 @default.
• W2113062593 cites W2046395086 @default.
• W2113062593 cites W2050817965 @default.
• W2113062593 cites W2051788298 @default.
• W2113062593 cites W2054851762 @default.
• W2113062593 cites W2067592930 @default.
• W2113062593 cites W2071447525 @default.
• W2113062593 cites W2074085337 @default.
• W2113062593 cites W2076403167 @default.
• W2113062593 cites W2077875294 @default.
• W2113062593 cites W2080875486 @default.
• W2113062593 cites W2085968319 @default.
• W2113062593 cites W2086562272 @default.
• W2113062593 cites W2093219983 @default.
• W2113062593 cites W2093879884 @default.
• W2113062593 cites W2094063881 @default.
• W2113062593 cites W2098249941 @default.
• W2113062593 cites W2123205169 @default.
• W2113062593 cites W2129662130 @default.
• W2113062593 cites W2133627256 @default.
• W2113062593 cites W2134773980 @default.
• W2113062593 cites W2146167376 @default.
• W2113062593 cites W2147643260 @default.
• W2113062593 cites W2148013477 @default.
• W2113062593 cites W2152284832 @default.
• W2113062593 cites W2162602904 @default.
• W2113062593 cites W2171614850 @default.
• W2113062593 doi "https://doi.org/10.1016/j.neuropharm.2009.01.014" @default.
• W2113062593 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3098385" @default.
• W2113062593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19705552" @default.
• W2113062593 hasPublicationYear "2009" @default.
• W2113062593 type Work @default.
• W2113062593 sameAs 2113062593 @default.
• W2113062593 citedByCount "5" @default.
• W2113062593 countsByYear W21130625932012 @default.
• W2113062593 countsByYear W21130625932013 @default.
• W2113062593 crossrefType "journal-article" @default.
• W2113062593 hasAuthorship W2113062593A5001346835 @default.
• W2113062593 hasAuthorship W2113062593A5019305436 @default.
• W2113062593 hasAuthorship W2113062593A5046756440 @default.
• W2113062593 hasAuthorship W2113062593A5060342234 @default.
• W2113062593 hasAuthorship W2113062593A5087417185 @default.
• W2113062593 hasAuthorship W2113062593A5089448145 @default.
• W2113062593 hasBestOaLocation W21130625931 @default.
• W2113062593 hasConcept C12554922 @default.
• W2113062593 hasConcept C125705527 @default.
• W2113062593 hasConcept C134018914 @default.
• W2113062593 hasConcept C135903288 @default.
• W2113062593 hasConcept C142669718 @default.
• W2113062593 hasConcept C1491633281 @default.
• W2113062593 hasConcept C169760540 @default.
• W2113062593 hasConcept C185592680 @default.
• W2113062593 hasConcept C2777172819 @default.
• W2113062593 hasConcept C2778186239 @default.
• W2113062593 hasConcept C2778541603 @default.
• W2113062593 hasConcept C2779530196 @default.
• W2113062593 hasConcept C2993400109 @default.
• W2113062593 hasConcept C486523 @default.
• W2113062593 hasConcept C55493867 @default.
• W2113062593 hasConcept C71240020 @default.
• W2113062593 hasConcept C86803240 @default.
• W2113062593 hasConcept C95444343 @default.
• W2113062593 hasConceptScore W2113062593C12554922 @default.
• W2113062593 hasConceptScore W2113062593C125705527 @default.
• W2113062593 hasConceptScore W2113062593C134018914 @default.
• W2113062593 hasConceptScore W2113062593C135903288 @default.
• W2113062593 hasConceptScore W2113062593C142669718 @default.
• W2113062593 hasConceptScore W2113062593C1491633281 @default.
• W2113062593 hasConceptScore W2113062593C169760540 @default.
• W2113062593 hasConceptScore W2113062593C185592680 @default.
• W2113062593 hasConceptScore W2113062593C2777172819 @default.
• W2113062593 hasConceptScore W2113062593C2778186239 @default.
• W2113062593 hasConceptScore W2113062593C2778541603 @default.

• next