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• W2113067107 abstract "SUMMARY To test the hypothesis that cortisol has a regulatory role in fish muscle glycogenesis post-exercise, rainbow trout were treated 1 h prior to exercise with either saline (control) or metyrapone (2-methyl-1,2-di-3-pyridyl-1-propanone) to block cortisol synthesis. Following exercise(time 0), half of the metyrapone-treated fish received a single injection of cortisol, to mimic the post-exercise rise usually observed. Muscle glycogen and the relative activities of glycogen phosphorylase a (Phos a) and glycogen synthase I (GSase I), regulatory enzymes for glycogen resynthesis, were monitored 4 h post-exercise. Metyrapone treatment succeeded in blocking the post-exercise rise in plasma cortisol(17±2 vs 118±13 ng ml–1 in controls at time 0), and cortisol injection resulted in a larger and more prolonged cortisol increase than in controls (159±22 vs 121±14 ng ml–1 in controls at 1 h). Muscle glycogen was completely restored in the metyrapone-treated fish within 2 h after exercise(8.3±0.6 vs 8±0.7 μmol g–1pre-exercise), only partially restored in control fish at 4 h (5.4±01.4 vs 8.8±1.3 μmol g–1 pre-exercise), and not at all in cortisol-treated fish (1.0±0.5 μmol g–1at 4 h). The rapid glycogen resynthesis in the metyrapone-treated fish was associated with a more rapid inactivation of Phos a and stimulation of GSase I compared to controls. In cortisol-treated fish, Phos a activity persisted throughout 4 h post-exercise; there was also a significant stimulation of GSase I activity. As a consequence of dual activation of Phos a and GSase I, glycogen cycling probably occurred, thus preventing net synthesis. This explains why the post-exercise elevation of cortisol inhibits net glycogen synthesis in trout muscle." @default.
• W2113067107 created "2016-06-24" @default.
• W2113067107 creator A5009192212 @default.
• W2113067107 date "2003-09-15" @default.
• W2113067107 modified "2023-10-14" @default.
• W2113067107 title "A regulatory role for cortisol in muscle glycogen metabolism in rainbow trout <i>Oncorhynchus mykiss</i> Walbaum" @default.
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• W2113067107 doi "https://doi.org/10.1242/jeb.00538" @default.
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