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• W2113067463 abstract "No AccessJournal of UrologyReflux1 Oct 2004TUMOR NECROSIS FACTOR-α GENE POLYMORPHISM IN REFLUX NEPHROPATHY VALERIA SOLARI, SEAN ENNIS, SALVATORE CASCIO, and PREM PURI VALERIA SOLARIVALERIA SOLARI More articles by this author , SEAN ENNISSEAN ENNIS More articles by this author , SALVATORE CASCIOSALVATORE CASCIO More articles by this author , and PREM PURIPREM PURI More articles by this author View All Author Informationhttps://doi.org/10.1097/01.ju.0000140210.12175.69AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Interstitial scarring contributes to the progression of renal failure in reflux nephropathy. The proinflammatory cytokine tumor necrosis factor-α (TNF-α) has been implicated in the disease susceptibility and pathogenesis of several inflammatory diseases promoting interstitial infiltration of inflammatory cells. We evaluate the frequency of TNF-α gene polymorphism in patients with reflux nephropathy. Material and Methods: Renal scaring was evaluated with 99technetium dimercapto-succinic acid renal scan. Genotyping was performed on 104 patients with reflux nephropathy and 30 controls for the TNF-α gene polymorphisms using polymerase chain reaction and restriction digest. This polymorphism involved a guanidine to adenosine transition at position −308 and was designated as TNF1 (−308G) and TNF2 (−308A). Results: The allele frequencies of TNF1 and TNF2 were 18.8% and 81.2% in patients with reflux nephropathy and 76.7% and 23.3% in controls, respectively. The genotype distribution of TNF-α-AA was significantly higher (66.4% vs 10%, p <0.05), while the TNF-α-GG was lower (13.4% vs 60%, p <0.05) in patients with reflux nephropathy compared to controls. Conclusions: This study demonstrates for the first time the association of the cytokine TNF-α gene polymorphism in patients with reflux nephropathy. Our data suggest that patients with vesicoureteral reflux and TNF-α AA genotype may have increased susceptibility to reflux nephropathy. References 1 : Hypertension in reflux nephropathy. BJU Int1999; 83: 1. Google Scholar 2 : The glomerular changes in children with reflux nephropathy. J Pathol1990; 162: 245. Google Scholar 3 : The inflammatory response and tissue damage. The example of renal scars following acute renal damage. Pediatr Nephrol1987; 1: 615. Google Scholar 4 : Tumour necrosis factor. In: Guidebook to Cytokines and Their Receptors. Edited by . Oxford: Oxford University Press1994: 103. Google Scholar 5 : Production of tumor necrosis factor alpha by rat mesangial cells in response to bacterial lipopolysaccharide. Kidney Int1989; 35: 1111. Google Scholar 6 : Transcriptional and posttranscriptional regulation of tumor necrosis factor gene expression in human monocytes. J Clin Invest1988; 81: 1506. 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Google Scholar 13 : Nitric oxide, enhanced by macrophage-colony stimulating factor, mediates renal damage in reflux nephropathy. Kidney Int2002; 62: 507. Google Scholar 14 : Monocyte adhesion to mesangial matrix modulates cytokine and metalloproteinase production. Kidney Int2003; 63: 889. Google Scholar 15 : Cytokine gene expression during experimental escherichia coli pyelonephritis in mice. J Urol1997; 158: 1576. Link, Google Scholar 16 : Transforming growth factor beta in tissue fibrosis. N Engl J Med1994; 331: 1286. Google Scholar 17 : Increased release of tumor necrosis factor-α by monocytes from patients with glomelulonephritis. Clin Nephrol1993; 40: 148. Google Scholar 18 : Tumor necrosis factor production by glomerular macrophages in anti-glomerular basement membrane glomerulonephritis in rabbits. Lab Invest1991; 65: 272. Google Scholar From the Children's Research Centre, Our Lady's Hospital for Sick Children and University College, Dublin, Ireland© 2004 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited bySavvidou A, Bitsori M, Choumerianou D, Karatzi M, Kalmanti M and Galanakis E (2018) Polymorphisms of the TNF-α and ACE Genes, and Renal Scarring in Infants With Urinary Tract InfectionJournal of Urology, VOL. 183, NO. 2, (684-687), Online publication date: 1-Feb-2010.Faust W, Diaz M and Pohl H (2018) Incidence of Post-Pyelonephritic Renal Scarring: A Meta-Analysis of the Dimercapto-Succinic Acid LiteratureJournal of Urology, VOL. 181, NO. 1, (290-298), Online publication date: 1-Jan-2009.Mohanan N, Colhoun E and Puri P (2008) Renal Parenchymal Damage in Intermediate and High Grade Infantile Vesicoureteral RefluxJournal of Urology, VOL. 180, NO. 4S, (1635-1638), Online publication date: 1-Oct-2008. Volume 172Issue 4 Part 2October 2004Page: 1604-1606 Advertisement Copyright & Permissions© 2004 by American Urological Association, Inc.Keywordskidney nephropathyvesico-ureteral refluxpolymorphism geneticstumor necrosis factorMetricsAuthor Information VALERIA SOLARI More articles by this author SEAN ENNIS More articles by this author SALVATORE CASCIO More articles by this author PREM PURI More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2113067463 title "TUMOR NECROSIS FACTOR-α GENE POLYMORPHISM IN REFLUX NEPHROPATHY" @default.
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