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• W2113078618 abstract "SUMMARY The study of 87 adults of different ages, including 15 centenarians, selected for their healthy status, showed that profound changes of humoral immunity occur throughout life. In particuIar, a statistically significant age-reIated increase of the serum level of immunoglobulin cIasses (IgG and IgA but not IgM) and IgG subcIasses (IgG1, 2 and 3, but not IgG4) was detected. A parallel age-related decrease of circuIating B cells was also observed. The hypothesis of a complex derangement of B cell function and/or compartmentalization with age is put forward, together with the proposal that healthy centenarians (as representative of successful ageing) may be helpful in identifying the physiological age-reIated modifications of the immune system." @default.
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• W2113078618 date "1992-11-01" @default.
• W2113078618 modified "2023-09-27" @default.
• W2113078618 title "Changes in circuIating B cells and immunoglobulin cIasses and subcIasses in a healthy aged popuIation" @default.
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• W2113078618 doi "https://doi.org/10.1111/j.1365-2249.1992.tb07954.x" @default.
• W2113078618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1554614" @default.
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