FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113083024> ?p ?o ?g. }

• W2113083024 endingPage "468" @default.
• W2113083024 startingPage "458" @default.
• W2113083024 abstract "The environmental contamination by dispersion of depleted uranium (DU) might result in its chronic ingestion of DU by local populations. The aim of this study was to determine if chronic ingestion of DU at low doses induces inflammatory reactions in intestine, first biological system exposed to uranium after ingestion. Experiments were performed with rats receiving uranium in drinking water (40 mg/l) during 3, 6, or 9 months. Several parameters referring to prostaglandin, histamine, cytokine, and nitric oxide (NO) pathways were assessed in ileum. Concerning the prostaglandin pathway, a twofold increase in gene expression of cyclooxygenase of type 2 was noted after 6 months, with no changes in prostaglandins levels. At the same time, a decrease in mast cell number was observed without any changes in histamine levels. Experiments on cytokines showed increased gene expression of interleukin (IL)-1β and IL-10 at 6 months, and decreased messenger RNA level of CCL-2. This change was associated with decreased macrophage density. An opposite effect of DU was induced on neutrophils, since increased number was observed at 3 (×1.7) and 9 months (×3). The results obtained on NO pathway seemed to indicate that DU exposure inhibited this pathway (decreased endothelial NO synthase messenger RNA, inductive NO synthase activity and NO2−/NO3− levels) at 6 months. In conclusion, this study demonstrated that chronic ingestion of DU-induced time-dependent modifications of inflammatory pathways, notably in terms of immune cell content. The ultimate effects of DU contamination might be pathogenic by suppressing defense mechanisms or inducing hypersensitivity. Further experiments should be thus performed to determine real consequences on intestinal response to oral antigens." @default.
• W2113083024 created "2016-06-24" @default.
• W2113083024 creator A5012385951 @default.
• W2113083024 creator A5022363547 @default.
• W2113083024 creator A5031095099 @default.
• W2113083024 creator A5033297146 @default.
• W2113083024 creator A5049815226 @default.
• W2113083024 creator A5059687911 @default.
• W2113083024 creator A5088239068 @default.
• W2113083024 creator A5091839466 @default.
• W2113083024 date "2007-04-10" @default.
• W2113083024 modified "2023-10-15" @default.
• W2113083024 title "Modifications of Inflammatory Pathways in Rat Intestine Following Chronic Ingestion of Depleted Uranium" @default.
• W2113083024 cites W1265846065 @default.
• W2113083024 cites W144264313 @default.
• W2113083024 cites W1965308245 @default.
• W2113083024 cites W1967746821 @default.
• W2113083024 cites W1970068226 @default.
• W2113083024 cites W1982017141 @default.
• W2113083024 cites W1983043017 @default.
• W2113083024 cites W1994317328 @default.
• W2113083024 cites W1999643058 @default.
• W2113083024 cites W2007698764 @default.
• W2113083024 cites W2011349330 @default.
• W2113083024 cites W2020329472 @default.
• W2113083024 cites W2024481637 @default.
• W2113083024 cites W2027665651 @default.
• W2113083024 cites W2033246888 @default.
• W2113083024 cites W2034170040 @default.
• W2113083024 cites W2037421698 @default.
• W2113083024 cites W2038606085 @default.
• W2113083024 cites W2040803317 @default.
• W2113083024 cites W2044704569 @default.
• W2113083024 cites W2045836911 @default.
• W2113083024 cites W2050461157 @default.
• W2113083024 cites W2051469655 @default.
• W2113083024 cites W2056674854 @default.
• W2113083024 cites W2074799237 @default.
• W2113083024 cites W2075241312 @default.
• W2113083024 cites W2076726354 @default.
• W2113083024 cites W2080803812 @default.
• W2113083024 cites W2081681557 @default.
• W2113083024 cites W2086906202 @default.
• W2113083024 cites W2094699029 @default.
• W2113083024 cites W2101335576 @default.
• W2113083024 cites W2101418233 @default.
• W2113083024 cites W2102275044 @default.
• W2113083024 cites W2117638652 @default.
• W2113083024 cites W2136529530 @default.
• W2113083024 cites W2160455720 @default.
• W2113083024 cites W2164775461 @default.
• W2113083024 cites W2165771755 @default.
• W2113083024 cites W2168438077 @default.
• W2113083024 cites W2172027330 @default.
• W2113083024 cites W2176725552 @default.
• W2113083024 cites W2284948629 @default.
• W2113083024 cites W2359568326 @default.
• W2113083024 cites W2466384217 @default.
• W2113083024 cites W991747599 @default.
• W2113083024 doi "https://doi.org/10.1093/toxsci/kfm132" @default.
• W2113083024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17566059" @default.
• W2113083024 hasPublicationYear "2007" @default.
• W2113083024 type Work @default.
• W2113083024 sameAs 2113083024 @default.
• W2113083024 citedByCount "40" @default.
• W2113083024 countsByYear W21130830242012 @default.
• W2113083024 countsByYear W21130830242013 @default.
• W2113083024 countsByYear W21130830242014 @default.
• W2113083024 countsByYear W21130830242016 @default.
• W2113083024 countsByYear W21130830242017 @default.
• W2113083024 countsByYear W21130830242018 @default.
• W2113083024 countsByYear W21130830242019 @default.
• W2113083024 countsByYear W21130830242020 @default.
• W2113083024 countsByYear W21130830242021 @default.
• W2113083024 countsByYear W21130830242022 @default.
• W2113083024 countsByYear W21130830242023 @default.
• W2113083024 crossrefType "journal-article" @default.
• W2113083024 hasAuthorship W2113083024A5012385951 @default.
• W2113083024 hasAuthorship W2113083024A5022363547 @default.
• W2113083024 hasAuthorship W2113083024A5031095099 @default.
• W2113083024 hasAuthorship W2113083024A5033297146 @default.
• W2113083024 hasAuthorship W2113083024A5049815226 @default.
• W2113083024 hasAuthorship W2113083024A5059687911 @default.
• W2113083024 hasAuthorship W2113083024A5088239068 @default.
• W2113083024 hasAuthorship W2113083024A5091839466 @default.
• W2113083024 hasBestOaLocation W21130830241 @default.
• W2113083024 hasConcept C1122143 @default.
• W2113083024 hasConcept C126322002 @default.
• W2113083024 hasConcept C134018914 @default.
• W2113083024 hasConcept C185592680 @default.
• W2113083024 hasConcept C193230392 @default.
• W2113083024 hasConcept C203014093 @default.
• W2113083024 hasConcept C2777226302 @default.
• W2113083024 hasConcept C2777622882 @default.
• W2113083024 hasConcept C2779726688 @default.
• W2113083024 hasConcept C2780664492 @default.
• W2113083024 hasConcept C519581460 @default.
• W2113083024 hasConcept C71924100 @default.

• next