FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113099054> ?p ?o ?g. }

• W2113099054 endingPage "247" @default.
• W2113099054 startingPage "241" @default.
• W2113099054 abstract "Abstract Buffering of the brain extracellular fluid is catalyzed by carbonic anhydrase (CA) activity. Whereas the extracellular isoform CA XIV has been localized exclusively to neurons in the brain, and to glial cells in the retina, there has been uncertainty regarding the form or forms of CA on the surface of brain astrocytes. We addressed this issue using physiological methods on cultured and acutely dissociated rat astrocytes. Prior work showed that the intracellular lactate‐induced acidification (LIA) of astrocytes is diminished by benzolamide, a poorly permeant, nonspecific CA inhibitor. We demonstrate that pretreatment of astrocytes with phosphatidylinositol‐specific phospholipase C (PI‐PLC) results in a similar inhibition of the mean LIA (by 66 ± 3%), suggesting that the glycosylphosphatidylinositol‐anchored CA IV was responsible. Pretreatment of astrocytes with CA IV inhibitory antisera also markedly reduced the mean LIA in both cultured cortical (by 46 ± 4%) and acutely dissociated hippocampal astrocytes (by 54 ± 8%). Pre‐immune sera had no effect. The inhibition produced by PIPLC or CA IV antisera was not significantly less than that by benzolamide, suggesting that the majority of detectable surface CA activity was attributable to CA IV. Thus, our data collectively document the presence of CAIV on the surface of brain astrocytes, and suggest that this is the predominant CA isoform on these cells. © 2005 Wiley‐Liss, Inc." @default.
• W2113099054 created "2016-06-24" @default.
• W2113099054 creator A5010543315 @default.
• W2113099054 creator A5022331909 @default.
• W2113099054 creator A5053998731 @default.
• W2113099054 creator A5056456168 @default.
• W2113099054 creator A5071547468 @default.
• W2113099054 date "2005-11-01" @default.
• W2113099054 modified "2023-10-13" @default.
• W2113099054 title "Functional demonstration of surface carbonic anhydrase IV activity on rat astrocytes" @default.
• W2113099054 cites W1135664569 @default.
• W2113099054 cites W1494185109 @default.
• W2113099054 cites W1502290520 @default.
• W2113099054 cites W1510623503 @default.
• W2113099054 cites W1544125967 @default.
• W2113099054 cites W1651958095 @default.
• W2113099054 cites W1970587817 @default.
• W2113099054 cites W1982034154 @default.
• W2113099054 cites W1984028198 @default.
• W2113099054 cites W1990885547 @default.
• W2113099054 cites W1990917620 @default.
• W2113099054 cites W1993257138 @default.
• W2113099054 cites W1998976350 @default.
• W2113099054 cites W2003801072 @default.
• W2113099054 cites W2004759191 @default.
• W2113099054 cites W2013371301 @default.
• W2113099054 cites W2022103979 @default.
• W2113099054 cites W2024343314 @default.
• W2113099054 cites W2025168312 @default.
• W2113099054 cites W2026151255 @default.
• W2113099054 cites W2039430665 @default.
• W2113099054 cites W2055891615 @default.
• W2113099054 cites W2063320267 @default.
• W2113099054 cites W2068317922 @default.
• W2113099054 cites W2071787267 @default.
• W2113099054 cites W2077288475 @default.
• W2113099054 cites W2078754431 @default.
• W2113099054 cites W2082294564 @default.
• W2113099054 cites W2089997291 @default.
• W2113099054 cites W2103201042 @default.
• W2113099054 cites W2123781965 @default.
• W2113099054 cites W2130630814 @default.
• W2113099054 cites W2131995833 @default.
• W2113099054 cites W2142167467 @default.
• W2113099054 cites W2146865913 @default.
• W2113099054 cites W2156302680 @default.
• W2113099054 cites W2161820871 @default.
• W2113099054 cites W2165502648 @default.
• W2113099054 cites W2187511581 @default.
• W2113099054 cites W2297890963 @default.
• W2113099054 cites W4238605098 @default.
• W2113099054 doi "https://doi.org/10.1002/glia.20277" @default.
• W2113099054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16265666" @default.
• W2113099054 hasPublicationYear "2005" @default.
• W2113099054 type Work @default.
• W2113099054 sameAs 2113099054 @default.
• W2113099054 citedByCount "45" @default.
• W2113099054 countsByYear W21130990542012 @default.
• W2113099054 countsByYear W21130990542013 @default.
• W2113099054 countsByYear W21130990542014 @default.
• W2113099054 countsByYear W21130990542015 @default.
• W2113099054 countsByYear W21130990542017 @default.
• W2113099054 countsByYear W21130990542018 @default.
• W2113099054 countsByYear W21130990542019 @default.
• W2113099054 countsByYear W21130990542020 @default.
• W2113099054 countsByYear W21130990542021 @default.
• W2113099054 countsByYear W21130990542022 @default.
• W2113099054 countsByYear W21130990542023 @default.
• W2113099054 crossrefType "journal-article" @default.
• W2113099054 hasAuthorship W2113099054A5010543315 @default.
• W2113099054 hasAuthorship W2113099054A5022331909 @default.
• W2113099054 hasAuthorship W2113099054A5053998731 @default.
• W2113099054 hasAuthorship W2113099054A5056456168 @default.
• W2113099054 hasAuthorship W2113099054A5071547468 @default.
• W2113099054 hasConcept C104317684 @default.
• W2113099054 hasConcept C148762608 @default.
• W2113099054 hasConcept C169760540 @default.
• W2113099054 hasConcept C181199279 @default.
• W2113099054 hasConcept C2775914622 @default.
• W2113099054 hasConcept C2777542381 @default.
• W2113099054 hasConcept C2778597717 @default.
• W2113099054 hasConcept C2780884517 @default.
• W2113099054 hasConcept C28406088 @default.
• W2113099054 hasConcept C529278444 @default.
• W2113099054 hasConcept C53345823 @default.
• W2113099054 hasConcept C55493867 @default.
• W2113099054 hasConcept C79879829 @default.
• W2113099054 hasConcept C86803240 @default.
• W2113099054 hasConcept C95444343 @default.
• W2113099054 hasConceptScore W2113099054C104317684 @default.
• W2113099054 hasConceptScore W2113099054C148762608 @default.
• W2113099054 hasConceptScore W2113099054C169760540 @default.
• W2113099054 hasConceptScore W2113099054C181199279 @default.
• W2113099054 hasConceptScore W2113099054C2775914622 @default.
• W2113099054 hasConceptScore W2113099054C2777542381 @default.
• W2113099054 hasConceptScore W2113099054C2778597717 @default.
• W2113099054 hasConceptScore W2113099054C2780884517 @default.
• W2113099054 hasConceptScore W2113099054C28406088 @default.

• next