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• W2113101845 abstract "Evidence has accumulated that some of the angiotensin II AT 1 receptor antagonists have insulin‐sensitizing property. We thus examined the effect of telmisartan on insulin action using 3T3‐L1 adipocytes. With standard differentiation inducers, a higher dose of telmisartan effectively facilitated differentiation of 3T3‐L1 preadipocytes. Treatment of both differentiating adipocytes and fully differentiated adipocytes with telmisartan caused a dose‐dependent increase in mRNA levels for PPARγ target genes such as aP2 and adiponectin. By contrast, telmisartan attenuated 11β‐hydroxysteroid dehydrogenase type 1 mRNA level in differentiated adipocytes. Of note, we demonstrated for the first time that telmisartan augmented GLUT4 protein expression and 2‐deoxy glucose uptake both in basal and insulin‐stimulated state of adipocytes, which may contribute, at least partly, to its insulin‐sensitizing ability." @default.
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• W2113101845 date "2004-09-25" @default.
• W2113101845 modified "2023-10-13" @default.
• W2113101845 title "An angiotensin II AT₁receptor antagonist, telmisartan augments glucose uptake and GLUT4 protein expression in 3T3-L1 adipocytes" @default.
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• W2113101845 doi "https://doi.org/10.1016/j.febslet.2004.09.027" @default.
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