Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113103898> ?p ?o ?g. }
- W2113103898 endingPage "113" @default.
- W2113103898 startingPage "105" @default.
- W2113103898 abstract "Developmental exposure to the organophosphorous insecticide chlorpyrifos (CPF) induces long-term effects on brain and behavior in laboratory rodents. We evaluated in adult mice the behavioral effects of either fetal and/or neonatal CPF exposure at doses not inhibiting fetal and neonatal brain cholinesterase. CPF (3 or 6 mg/kg) was given by oral treatment to pregnant females on gestational days 15–18 and offspring were treated sc (1 or 3 mg/kg) on postnatal days (PNDs) 11–14. Serum and brain acetylcholinesterase (AChE) activity was evaluated at birth and 24 h from termination of postnatal treatments. On PND 70, male mice were assessed for spontaneous motor activity in an open-field test and in a socioagonistic encounter with an unfamiliar conspecific. Virgin females underwent a maternal induction test following presentation of foster pups. Both sexes were subjected to a plus-maze test to evaluate exploration and anxiety levels. Gestational and postnatal CPF exposure (higher doses) affected motor activity in the open field and enhanced synergically agonistic behavior. Postnatal CPF exposure increased maternal responsiveness toward pups in females. Mice of both sexes exposed to postnatal CPF showed reduced anxiety response in the plus-maze, an effect greater in females. Altogether, developmental exposure to CPF at doses that do not cause brain AChE inhibition induces long-term alterations in sex-specific behavior patterns of the mouse species. Late neonatal exposure on PNDs 11–14 was the most effective in causing behavioral changes. These findings support the hypothesis that developmental CPF may represent a risk factor for increased vulnerability to neurodevelopmental disorders in humans." @default.
- W2113103898 created "2016-06-24" @default.
- W2113103898 creator A5023516355 @default.
- W2113103898 creator A5054749290 @default.
- W2113103898 creator A5067366215 @default.
- W2113103898 creator A5068340647 @default.
- W2113103898 creator A5077654346 @default.
- W2113103898 creator A5085689068 @default.
- W2113103898 creator A5091698786 @default.
- W2113103898 date "2006-06-07" @default.
- W2113103898 modified "2023-10-07" @default.
- W2113103898 title "Developmental Neurotoxicity of Organophosphorous Pesticides: Fetal and Neonatal Exposure to Chlorpyrifos Alters Sex-Specific Behaviors at Adulthood in Mice" @default.
- W2113103898 cites W1971048984 @default.
- W2113103898 cites W1971354169 @default.
- W2113103898 cites W1993737224 @default.
- W2113103898 cites W1995714241 @default.
- W2113103898 cites W2004180568 @default.
- W2113103898 cites W2007612689 @default.
- W2113103898 cites W2012471271 @default.
- W2113103898 cites W2021361907 @default.
- W2113103898 cites W2021807237 @default.
- W2113103898 cites W2029086126 @default.
- W2113103898 cites W2029558151 @default.
- W2113103898 cites W2033981805 @default.
- W2113103898 cites W2035072448 @default.
- W2113103898 cites W2035807588 @default.
- W2113103898 cites W2039989651 @default.
- W2113103898 cites W2041561931 @default.
- W2113103898 cites W2042311846 @default.
- W2113103898 cites W2042859546 @default.
- W2113103898 cites W2045111417 @default.
- W2113103898 cites W2051394367 @default.
- W2113103898 cites W2052893224 @default.
- W2113103898 cites W2054254245 @default.
- W2113103898 cites W2055972657 @default.
- W2113103898 cites W2062313984 @default.
- W2113103898 cites W2063509423 @default.
- W2113103898 cites W2065008438 @default.
- W2113103898 cites W2065289459 @default.
- W2113103898 cites W2068468110 @default.
- W2113103898 cites W2073563986 @default.
- W2113103898 cites W2076435711 @default.
- W2113103898 cites W2080164857 @default.
- W2113103898 cites W2080221739 @default.
- W2113103898 cites W2082946264 @default.
- W2113103898 cites W2090237062 @default.
- W2113103898 cites W2091382604 @default.
- W2113103898 cites W2121906269 @default.
- W2113103898 cites W2199954293 @default.
- W2113103898 cites W4241598466 @default.
- W2113103898 doi "https://doi.org/10.1093/toxsci/kfl032" @default.
- W2113103898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16760416" @default.
- W2113103898 hasPublicationYear "2006" @default.
- W2113103898 type Work @default.
- W2113103898 sameAs 2113103898 @default.
- W2113103898 citedByCount "154" @default.
- W2113103898 countsByYear W21131038982012 @default.
- W2113103898 countsByYear W21131038982013 @default.
- W2113103898 countsByYear W21131038982014 @default.
- W2113103898 countsByYear W21131038982015 @default.
- W2113103898 countsByYear W21131038982016 @default.
- W2113103898 countsByYear W21131038982017 @default.
- W2113103898 countsByYear W21131038982018 @default.
- W2113103898 countsByYear W21131038982019 @default.
- W2113103898 countsByYear W21131038982020 @default.
- W2113103898 countsByYear W21131038982021 @default.
- W2113103898 countsByYear W21131038982022 @default.
- W2113103898 countsByYear W21131038982023 @default.
- W2113103898 crossrefType "journal-article" @default.
- W2113103898 hasAuthorship W2113103898A5023516355 @default.
- W2113103898 hasAuthorship W2113103898A5054749290 @default.
- W2113103898 hasAuthorship W2113103898A5067366215 @default.
- W2113103898 hasAuthorship W2113103898A5068340647 @default.
- W2113103898 hasAuthorship W2113103898A5077654346 @default.
- W2113103898 hasAuthorship W2113103898A5085689068 @default.
- W2113103898 hasAuthorship W2113103898A5091698786 @default.
- W2113103898 hasBestOaLocation W21131038981 @default.
- W2113103898 hasConcept C112672928 @default.
- W2113103898 hasConcept C118552586 @default.
- W2113103898 hasConcept C126322002 @default.
- W2113103898 hasConcept C134018914 @default.
- W2113103898 hasConcept C161176658 @default.
- W2113103898 hasConcept C172680121 @default.
- W2113103898 hasConcept C173586616 @default.
- W2113103898 hasConcept C181199279 @default.
- W2113103898 hasConcept C2776304672 @default.
- W2113103898 hasConcept C2776588719 @default.
- W2113103898 hasConcept C2778816929 @default.
- W2113103898 hasConcept C2779059548 @default.
- W2113103898 hasConcept C2779085643 @default.
- W2113103898 hasConcept C2779234561 @default.
- W2113103898 hasConcept C2779491297 @default.
- W2113103898 hasConcept C29730261 @default.
- W2113103898 hasConcept C42407357 @default.
- W2113103898 hasConcept C46973012 @default.
- W2113103898 hasConcept C54355233 @default.
- W2113103898 hasConcept C55493867 @default.
- W2113103898 hasConcept C558461103 @default.