FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113106822> ?p ?o ?g. }

• W2113106822 endingPage "264" @default.
• W2113106822 startingPage "255" @default.
• W2113106822 abstract "Objective: To investigate whether inhibition of mitochondrial p53 association using pifithrin-μ (PFT-μ) represents a potential novel neuroprotective strategy to combat perinatal hypoxic-ischemic (HI) brain damage. Methods: Seven-day-old rats were subjected to unilateral carotid artery occlusion and hypoxia followed by intraperitoneal treatment with PFT-μ, an inhibitor of p53 mitochondrial association or PFT-α an inhibitor of p53 transcriptional activity. Cerebral damage, sensorimotor and cognitive function, apoptotic pathways (cytosolic cytochrome c, Smac/DIABLO, active caspase 3), and oxidative stress (lipid peroxidation and PARP-1 cleavage) were investigated. Results: PFT-μ treatment completely prevented the HI-induced increase in mitochondrial p53 association at 3 hours and reduced neuronal damage at 48 hours post-HI. PFT-μ had long-term (6–10 weeks post-HI) beneficial effects as sensorimotor and cognitive outcome improved and infarct size was reduced by ∼79%. Neuroprotection by PFT-μ treatment was associated with strong inhibition of apoptotic pathways and reduced oxidative stress. Unexpectedly, PFT-μ also inhibited HI-induced upregulation of p53 target genes. However, the neuroprotective effect of inhibiting only p53 transcriptional activity by PFT-α was significantly smaller and did not involve reduced oxidative stress. Interpretation: We are the first to show that prevention of mitochondrial p53 association by PFT-μ strongly improves functional outcome and decreases lesion size after neonatal HI. PFT-μ not only inhibits mitochondrial release of cytochrome c, but also inhibits oxidative stress. We propose that as a consequence nuclear accumulation of p53 and transcription of proapoptotic target genes are prevented. In conclusion, targeting p53 mitochondrial association by PFT-μ may develop into a novel and powerful neuroprotective strategy. ANN NEUROL 2011;00:000–000" @default.
• W2113106822 created "2016-06-24" @default.
• W2113106822 creator A5003243052 @default.
• W2113106822 creator A5007674783 @default.
• W2113106822 creator A5028249851 @default.
• W2113106822 creator A5034845947 @default.
• W2113106822 creator A5042225204 @default.
• W2113106822 creator A5053579288 @default.
• W2113106822 creator A5065208828 @default.
• W2113106822 creator A5069137845 @default.
• W2113106822 creator A5090045839 @default.
• W2113106822 date "2011-06-14" @default.
• W2113106822 modified "2023-10-16" @default.
• W2113106822 title "Targeting the p53 pathway to protect the neonatal ischemic brain" @default.
• W2113106822 cites W132441100 @default.
• W2113106822 cites W1517407659 @default.
• W2113106822 cites W1969455851 @default.
• W2113106822 cites W1969790007 @default.
• W2113106822 cites W1975124019 @default.
• W2113106822 cites W1986782185 @default.
• W2113106822 cites W2002936090 @default.
• W2113106822 cites W2003667906 @default.
• W2113106822 cites W2008583799 @default.
• W2113106822 cites W2015555160 @default.
• W2113106822 cites W2017439846 @default.
• W2113106822 cites W2024248665 @default.
• W2113106822 cites W2025708152 @default.
• W2113106822 cites W2026036357 @default.
• W2113106822 cites W2027387206 @default.
• W2113106822 cites W2029026381 @default.
• W2113106822 cites W2031898343 @default.
• W2113106822 cites W2038636807 @default.
• W2113106822 cites W2044079387 @default.
• W2113106822 cites W2046374080 @default.
• W2113106822 cites W2059999514 @default.
• W2113106822 cites W2060513486 @default.
• W2113106822 cites W2060618478 @default.
• W2113106822 cites W2060988288 @default.
• W2113106822 cites W2063669247 @default.
• W2113106822 cites W2065346526 @default.
• W2113106822 cites W2066215889 @default.
• W2113106822 cites W2078504328 @default.
• W2113106822 cites W2080097363 @default.
• W2113106822 cites W2080766130 @default.
• W2113106822 cites W2082638983 @default.
• W2113106822 cites W2089822522 @default.
• W2113106822 cites W2091508411 @default.
• W2113106822 cites W2098951649 @default.
• W2113106822 cites W2103278596 @default.
• W2113106822 cites W2103735330 @default.
• W2113106822 cites W2135122869 @default.
• W2113106822 cites W2140220135 @default.
• W2113106822 cites W2146483565 @default.
• W2113106822 cites W2152554775 @default.
• W2113106822 cites W2160345685 @default.
• W2113106822 cites W2165997736 @default.
• W2113106822 cites W2167184679 @default.
• W2113106822 cites W2167885341 @default.
• W2113106822 cites W2172058095 @default.
• W2113106822 doi "https://doi.org/10.1002/ana.22413" @default.
• W2113106822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21674585" @default.
• W2113106822 hasPublicationYear "2011" @default.
• W2113106822 type Work @default.
• W2113106822 sameAs 2113106822 @default.
• W2113106822 citedByCount "87" @default.
• W2113106822 countsByYear W21131068222012 @default.
• W2113106822 countsByYear W21131068222013 @default.
• W2113106822 countsByYear W21131068222014 @default.
• W2113106822 countsByYear W21131068222015 @default.
• W2113106822 countsByYear W21131068222016 @default.
• W2113106822 countsByYear W21131068222017 @default.
• W2113106822 countsByYear W21131068222018 @default.
• W2113106822 countsByYear W21131068222019 @default.
• W2113106822 countsByYear W21131068222020 @default.
• W2113106822 countsByYear W21131068222021 @default.
• W2113106822 countsByYear W21131068222022 @default.
• W2113106822 countsByYear W21131068222023 @default.
• W2113106822 crossrefType "journal-article" @default.
• W2113106822 hasAuthorship W2113106822A5003243052 @default.
• W2113106822 hasAuthorship W2113106822A5007674783 @default.
• W2113106822 hasAuthorship W2113106822A5028249851 @default.
• W2113106822 hasAuthorship W2113106822A5034845947 @default.
• W2113106822 hasAuthorship W2113106822A5042225204 @default.
• W2113106822 hasAuthorship W2113106822A5053579288 @default.
• W2113106822 hasAuthorship W2113106822A5065208828 @default.
• W2113106822 hasAuthorship W2113106822A5069137845 @default.
• W2113106822 hasAuthorship W2113106822A5090045839 @default.
• W2113106822 hasConcept C104317684 @default.
• W2113106822 hasConcept C12519072 @default.
• W2113106822 hasConcept C126322002 @default.
• W2113106822 hasConcept C127561419 @default.
• W2113106822 hasConcept C134018914 @default.
• W2113106822 hasConcept C185592680 @default.
• W2113106822 hasConcept C190283241 @default.
• W2113106822 hasConcept C25498285 @default.
• W2113106822 hasConcept C2776151105 @default.
• W2113106822 hasConcept C2780829032 @default.
• W2113106822 hasConcept C28859421 @default.

• next