FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113113178> ?p ?o ?g. }

• W2113113178 endingPage "1133" @default.
• W2113113178 startingPage "1118" @default.
• W2113113178 abstract "Abstract Patient stratification biomarkers that enable the translation of cancer genetic knowledge into clinical use are essential for the successful and rapid development of emerging targeted anticancer therapeutics. Here, we describe the identification of patient stratification biomarkers for NVP-BGJ398, a novel and selective fibroblast growth factor receptor (FGFR) inhibitor. By intersecting genome-wide gene expression and genomic alteration data with cell line–sensitivity data across an annotated collection of cancer cell lines called the Cancer Cell Line Encyclopedia, we show that genetic alterations for FGFR family members predict for sensitivity to NVP-BGJ398. For the first time, we report oncogenic FGFR1 amplification in osteosarcoma as a potential patient selection biomarker. Furthermore, we show that cancer cell lines harboring FGF19 copy number gain at the 11q13 amplicon are sensitive to NVP-BGJ398 only when concomitant expression of β-klotho occurs. Thus, our findings provide the rationale for the clinical development of FGFR inhibitors in selected patients with cancer harboring tumors with the identified predictors of sensitivity. Significance: The success of a personalized medicine approach using targeted therapies ultimately depends on being able to identify the patients who will benefit the most from any given drug. To this end, we have integrated the molecular profiles for more than 500 cancer cell lines with sensitivity data for the novel anticancer drug NVP-BGJ398 and showed that FGFR genetic alterations are the most significant predictors for sensitivity. This work has ultimately endorsed the incorporation of specific patient selection biomakers in the clinical trials for NVP-BGJ398. Cancer Discov; 2(12); 1118–33. ©2012 AACR. Read the Commentary on this article by Loch and Pollock, p. 1081 This article is highlighted in the In This Issue feature, p. 1065" @default.
• W2113113178 created "2016-06-24" @default.
• W2113113178 creator A5006321055 @default.
• W2113113178 creator A5013958866 @default.
• W2113113178 creator A5014106423 @default.
• W2113113178 creator A5014834167 @default.
• W2113113178 creator A5016463584 @default.
• W2113113178 creator A5023874610 @default.
• W2113113178 creator A5028902202 @default.
• W2113113178 creator A5029569816 @default.
• W2113113178 creator A5038048525 @default.
• W2113113178 creator A5038931039 @default.
• W2113113178 creator A5045197865 @default.
• W2113113178 creator A5047916176 @default.
• W2113113178 creator A5053164042 @default.
• W2113113178 creator A5057346782 @default.
• W2113113178 creator A5057483557 @default.
• W2113113178 creator A5059937438 @default.
• W2113113178 creator A5060650383 @default.
• W2113113178 creator A5067169499 @default.
• W2113113178 creator A5075432128 @default.
• W2113113178 creator A5079148747 @default.
• W2113113178 creator A5079659004 @default.
• W2113113178 creator A5087018671 @default.
• W2113113178 creator A5089863595 @default.
• W2113113178 creator A5091179542 @default.
• W2113113178 date "2012-12-01" @default.
• W2113113178 modified "2023-10-18" @default.
• W2113113178 title "FGFR Genetic Alterations Predict for Sensitivity to NVP-BGJ398, a Selective Pan-FGFR Inhibitor" @default.
• W2113113178 cites W1563019250 @default.
• W2113113178 cites W1937853139 @default.
• W2113113178 cites W1969615213 @default.
• W2113113178 cites W1980823462 @default.
• W2113113178 cites W1986790385 @default.
• W2113113178 cites W1987170068 @default.
• W2113113178 cites W1991001144 @default.
• W2113113178 cites W1992354899 @default.
• W2113113178 cites W2023297465 @default.
• W2113113178 cites W2023568503 @default.
• W2113113178 cites W2024798441 @default.
• W2113113178 cites W2025183726 @default.
• W2113113178 cites W2043398720 @default.
• W2113113178 cites W2049480813 @default.
• W2113113178 cites W2054290966 @default.
• W2113113178 cites W2054399333 @default.
• W2113113178 cites W2056955003 @default.
• W2113113178 cites W2075790601 @default.
• W2113113178 cites W2082095884 @default.
• W2113113178 cites W2086082854 @default.
• W2113113178 cites W2089667109 @default.
• W2113113178 cites W2089735482 @default.
• W2113113178 cites W2093090488 @default.
• W2113113178 cites W2093775484 @default.
• W2113113178 cites W2095943598 @default.
• W2113113178 cites W2113727201 @default.
• W2113113178 cites W2115051889 @default.
• W2113113178 cites W2118155696 @default.
• W2113113178 cites W2137480884 @default.
• W2113113178 cites W2153056550 @default.
• W2113113178 cites W2157852151 @default.
• W2113113178 cites W2159060826 @default.
• W2113113178 cites W2164185692 @default.
• W2113113178 cites W32883903 @default.
• W2113113178 doi "https://doi.org/10.1158/2159-8290.cd-12-0210" @default.
• W2113113178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23002168" @default.
• W2113113178 hasPublicationYear "2012" @default.
• W2113113178 type Work @default.
• W2113113178 sameAs 2113113178 @default.
• W2113113178 citedByCount "275" @default.
• W2113113178 countsByYear W21131131782012 @default.
• W2113113178 countsByYear W21131131782013 @default.
• W2113113178 countsByYear W21131131782014 @default.
• W2113113178 countsByYear W21131131782015 @default.
• W2113113178 countsByYear W21131131782016 @default.
• W2113113178 countsByYear W21131131782017 @default.
• W2113113178 countsByYear W21131131782018 @default.
• W2113113178 countsByYear W21131131782019 @default.
• W2113113178 countsByYear W21131131782020 @default.
• W2113113178 countsByYear W21131131782021 @default.
• W2113113178 countsByYear W21131131782022 @default.
• W2113113178 countsByYear W21131131782023 @default.
• W2113113178 crossrefType "journal-article" @default.
• W2113113178 hasAuthorship W2113113178A5006321055 @default.
• W2113113178 hasAuthorship W2113113178A5013958866 @default.
• W2113113178 hasAuthorship W2113113178A5014106423 @default.
• W2113113178 hasAuthorship W2113113178A5014834167 @default.
• W2113113178 hasAuthorship W2113113178A5016463584 @default.
• W2113113178 hasAuthorship W2113113178A5023874610 @default.
• W2113113178 hasAuthorship W2113113178A5028902202 @default.
• W2113113178 hasAuthorship W2113113178A5029569816 @default.
• W2113113178 hasAuthorship W2113113178A5038048525 @default.
• W2113113178 hasAuthorship W2113113178A5038931039 @default.
• W2113113178 hasAuthorship W2113113178A5045197865 @default.
• W2113113178 hasAuthorship W2113113178A5047916176 @default.
• W2113113178 hasAuthorship W2113113178A5053164042 @default.
• W2113113178 hasAuthorship W2113113178A5057346782 @default.
• W2113113178 hasAuthorship W2113113178A5057483557 @default.
• W2113113178 hasAuthorship W2113113178A5059937438 @default.

• next