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• W2113114897 abstract "Dual conformational restriction: a new, highly constrained modification of the α-L-locked nucleic acid (α-L-LNA) scaffold that locks the sugar furanose ring in an N-type configuration and also restricts rotation around torsion angle γ was synthesized. This new modification increases the thermostability of an oligonucleotide duplex compared to using a single mode of constraint alone." @default.
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• W2113114897 date "2012-08-22" @default.
• W2113114897 modified "2023-10-18" @default.
• W2113114897 title "Structure-Based Design of a Highly Constrained Nucleic Acid Analogue: Improved Duplex Stabilization by Restricting Sugar Pucker and Torsion Angle<i>γ</i>" @default.
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• W2113114897 doi "https://doi.org/10.1002/anie.201203680" @default.
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