FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113116005> ?p ?o ?g. }

• W2113116005 endingPage "5342" @default.
• W2113116005 startingPage "5331" @default.
• W2113116005 abstract "Gfi-1B (growth factor independence-1B) gene is an erythroid-specific transcription factor, whose expression plays an essential role in erythropoiesis. Our laboratory has previously defined the human Gfi-1B promoter region and shown that GATA-1 mediates erythroid-specific Gfi-1B transcription. By further investigating the regulation of the Gfi-1B promoter, here we report that (i) Gfi-1B transcription is negatively regulated by its own gene product, (ii) GATA-1, instead of Gfi-1B, binds directly to the Gfi-1-like sites in the Gfi-1B promoter and (iii) Gfi-1B suppresses GATA-1-mediated stimulation of Gfi-1B promoter through their protein interaction. These results not only demonstrate that interaction of GATA-1 and Gfi-1B participates in a feedback regulatory pathway in controlling the expression of the Gfi-1B gene, but also provide the first evidence that Gfi-1B can exert its repression function by acting on GATA-1-mediated transcription without direct binding to the Gfi-1 site of the target genes. Based on these data, we propose that this negative auto-regulatory feedback loop is important in restricting the expression level of Gfi-1B, thus optimizing its function in erythroid cells." @default.
• W2113116005 created "2016-06-24" @default.
• W2113116005 creator A5066369283 @default.
• W2113116005 date "2005-09-07" @default.
• W2113116005 modified "2023-10-17" @default.
• W2113116005 title "GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells" @default.
• W2113116005 cites W1504158565 @default.
• W2113116005 cites W1844361913 @default.
• W2113116005 cites W1967894253 @default.
• W2113116005 cites W1977137693 @default.
• W2113116005 cites W1981460612 @default.
• W2113116005 cites W1986979962 @default.
• W2113116005 cites W1993243592 @default.
• W2113116005 cites W1994987603 @default.
• W2113116005 cites W1997582408 @default.
• W2113116005 cites W1998536026 @default.
• W2113116005 cites W2001772277 @default.
• W2113116005 cites W2015869769 @default.
• W2113116005 cites W2024520070 @default.
• W2113116005 cites W2025589527 @default.
• W2113116005 cites W2025847301 @default.
• W2113116005 cites W2049869441 @default.
• W2113116005 cites W2050807689 @default.
• W2113116005 cites W2054338068 @default.
• W2113116005 cites W2055568103 @default.
• W2113116005 cites W2065655094 @default.
• W2113116005 cites W2065855627 @default.
• W2113116005 cites W2088583545 @default.
• W2113116005 cites W2094431012 @default.
• W2113116005 cites W2094872845 @default.
• W2113116005 cites W2097184672 @default.
• W2113116005 cites W2109719547 @default.
• W2113116005 cites W2113260405 @default.
• W2113116005 cites W2115686505 @default.
• W2113116005 cites W2122616238 @default.
• W2113116005 cites W2136317405 @default.
• W2113116005 cites W2136352982 @default.
• W2113116005 cites W2141478246 @default.
• W2113116005 cites W2144473036 @default.
• W2113116005 cites W2147074981 @default.
• W2113116005 cites W2147561347 @default.
• W2113116005 cites W2156083214 @default.
• W2113116005 cites W2158444598 @default.
• W2113116005 cites W2162198627 @default.
• W2113116005 cites W2165118879 @default.
• W2113116005 cites W2464733971 @default.
• W2113116005 cites W43784428 @default.
• W2113116005 doi "https://doi.org/10.1093/nar/gki838" @default.
• W2113116005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1226314" @default.
• W2113116005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16177182" @default.
• W2113116005 hasPublicationYear "2005" @default.
• W2113116005 type Work @default.
• W2113116005 sameAs 2113116005 @default.
• W2113116005 citedByCount "45" @default.
• W2113116005 countsByYear W21131160052012 @default.
• W2113116005 countsByYear W21131160052013 @default.
• W2113116005 countsByYear W21131160052014 @default.
• W2113116005 countsByYear W21131160052015 @default.
• W2113116005 countsByYear W21131160052016 @default.
• W2113116005 countsByYear W21131160052017 @default.
• W2113116005 countsByYear W21131160052018 @default.
• W2113116005 countsByYear W21131160052019 @default.
• W2113116005 countsByYear W21131160052020 @default.
• W2113116005 countsByYear W21131160052021 @default.
• W2113116005 countsByYear W21131160052022 @default.
• W2113116005 countsByYear W21131160052023 @default.
• W2113116005 crossrefType "journal-article" @default.
• W2113116005 hasAuthorship W2113116005A5066369283 @default.
• W2113116005 hasBestOaLocation W21131160052 @default.
• W2113116005 hasConcept C101762097 @default.
• W2113116005 hasConcept C104317684 @default.
• W2113116005 hasConcept C138885662 @default.
• W2113116005 hasConcept C142455686 @default.
• W2113116005 hasConcept C150194340 @default.
• W2113116005 hasConcept C158448853 @default.
• W2113116005 hasConcept C165864922 @default.
• W2113116005 hasConcept C179926584 @default.
• W2113116005 hasConcept C186310378 @default.
• W2113116005 hasConcept C27153228 @default.
• W2113116005 hasConcept C41895202 @default.
• W2113116005 hasConcept C54355233 @default.
• W2113116005 hasConcept C86339819 @default.
• W2113116005 hasConcept C86803240 @default.
• W2113116005 hasConcept C95444343 @default.
• W2113116005 hasConceptScore W2113116005C101762097 @default.
• W2113116005 hasConceptScore W2113116005C104317684 @default.
• W2113116005 hasConceptScore W2113116005C138885662 @default.
• W2113116005 hasConceptScore W2113116005C142455686 @default.
• W2113116005 hasConceptScore W2113116005C150194340 @default.
• W2113116005 hasConceptScore W2113116005C158448853 @default.
• W2113116005 hasConceptScore W2113116005C165864922 @default.
• W2113116005 hasConceptScore W2113116005C179926584 @default.
• W2113116005 hasConceptScore W2113116005C186310378 @default.
• W2113116005 hasConceptScore W2113116005C27153228 @default.
• W2113116005 hasConceptScore W2113116005C41895202 @default.
• W2113116005 hasConceptScore W2113116005C54355233 @default.
• W2113116005 hasConceptScore W2113116005C86339819 @default.
• W2113116005 hasConceptScore W2113116005C86803240 @default.

• next