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• W2113117966 abstract "Abstract We consider a population that adapts to a gradually changing environment. Our aim is to describe how ecological and genetic factors combine to determine the genetic basis of adaptation. Specifically, we consider the evolution of a polygenic trait that is under stabilizing selection with a moving optimum. The ecological dynamics are defined by the strength of selection, $batchmode documentclass[fleqn,10pt,legalpaper]{article} usepackage{amssymb} usepackage{amsfonts} usepackage{amsmath} pagestyle{empty} begin{document} (mathrm{{tilde{{sigma}}}}) end{document}$, and the speed of the optimum, $batchmode documentclass[fleqn,10pt,legalpaper]{article} usepackage{amssymb} usepackage{amsfonts} usepackage{amsmath} pagestyle{empty} begin{document} ({tilde{v}}) end{document}$; the key genetic parameters are the mutation rate Θ and the variance of the effects of new mutations, ω. We develop analytical approximations within an “adaptive-walk” framework and describe how selection acts as a sieve that transforms a given distribution of new mutations into the distribution of adaptive substitutions. Our analytical results are complemented by individual-based simulations. We find that (i) the ecological dynamics have a strong effect on the distribution of adaptive substitutions and their impact depends largely on a single composite measure $batchmode documentclass[fleqn,10pt,legalpaper]{article} usepackage{amssymb} usepackage{amsfonts} usepackage{amsmath} pagestyle{empty} begin{document} (mathrm{{gamma}}{=}{tilde{v}}/(mathrm{{tilde{{sigma}}}}{Theta}mathrm{{omega}}^{3})) end{document}$, which combines the ecological and genetic parameters; (ii) depending on γ, we can distinguish two distinct adaptive regimes: for large γ the adaptive process is mutation limited and dominated by genetic constraints, whereas for small γ it is environmentally limited and dominated by the external ecological dynamics; (iii) deviations from the adaptive-walk approximation occur for large mutation rates, when different mutant alleles interact via linkage or epistasis; and (iv) in contrast to predictions from previous models assuming constant selection, the distribution of adaptive substitutions is generally not exponential." @default.
• W2113117966 created "2016-06-24" @default.
• W2113117966 creator A5032789220 @default.
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• W2113117966 date "2009-12-01" @default.
• W2113117966 modified "2023-10-16" @default.
• W2113117966 title "The Genetic Basis of Phenotypic Adaptation II: The Distribution of Adaptive Substitutions in the Moving Optimum Model" @default.
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• W2113117966 doi "https://doi.org/10.1534/genetics.109.106195" @default.
• W2113117966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2787432" @default.
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• W2113117966 hasPublicationYear "2009" @default.
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