FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113118834> ?p ?o ?g. }

• W2113118834 abstract "Abstract Background Organophosphates and pyrethroids are used widely in Brazil to control Aedes aegypti , the main vector of dengue viruses, under the auspices of the National Programme for Dengue Control. Resistance to these insecticides is widespread throughout Brazil. In Ceará the vector is present in 98% of districts and resistance to temephos has been reported previously. Here we measure resistance to temephos and the pyrethroid cypermethrin in three populations from Ceará and use biochemical and molecular assays to characterise resistance mechanisms. Results Resistance to temephos varied widely across the three studied populations, with resistance ratios (RR 95 ) of 7.2, 30 and 192.7 in Juazeiro do Norte, Barbalha and Crato respectively. The high levels of resistance detected in Barbalha and Crato (RR 95 ≥ 30) imply a reduction of temephos efficacy, and indeed in simulated field tests reduced effectiveness was observed for the Barbalha population. Two populations (Crato and Barbalha) were also resistant to cypermethrin, whilst Juazeiro do Norte showed only an altered susceptibility. The Ile1011Met kdr mutation was detected in all three populations and Val1016Ile in Crato and Juazeiro do Norte. 1011Met was significantly associated with resistance to cypermethrin in the Crato population. Biochemical tests showed that only the activity of esterases and GSTs, among the tested detoxification enzymes, was altered in these populations when compared with the Rockefeller strain. Conclusions Our results demonstrate that two A. aegypti populations from Ceará are under strong selection pressure by temephos, compromising the field effectiveness of this organophosphate. Our results also provide evidence that the process of reducing resistance to this larvicide in the field is difficult and slow and may require more than seven years for reversal. In addition, we show resistance to cypermethrin in two of the three populations studied, and for the first time the presence of the allele 1016Ile in mosquito populations from northeastern Brazil. A significant association between 1011M et and resistance was observed in one of the populations. Target-site mechanisms seem not to be implicated in temephos resistance, reinforcing the idea that for the studied populations, detoxification enzymes most likely play a major role in the resistance to this insecticide." @default.
• W2113118834 created "2016-06-24" @default.
• W2113118834 creator A5003178305 @default.
• W2113118834 creator A5013253015 @default.
• W2113118834 creator A5016910715 @default.
• W2113118834 creator A5039015276 @default.
• W2113118834 creator A5040776114 @default.
• W2113118834 creator A5044353413 @default.
• W2113118834 creator A5047273983 @default.
• W2113118834 creator A5048754510 @default.
• W2113118834 creator A5050619071 @default.
• W2113118834 creator A5067579923 @default.
• W2113118834 creator A5076805029 @default.
• W2113118834 creator A5079504528 @default.
• W2113118834 creator A5081238138 @default.
• W2113118834 date "2011-01-12" @default.
• W2113118834 modified "2023-10-01" @default.
• W2113118834 title "Insecticide resistance in Aedes aegypti populations from Ceará, Brazil" @default.
• W2113118834 cites W1490711099 @default.
• W2113118834 cites W1687421235 @default.
• W2113118834 cites W1835981108 @default.
• W2113118834 cites W1839046251 @default.
• W2113118834 cites W1963967347 @default.
• W2113118834 cites W1967564010 @default.
• W2113118834 cites W1991053646 @default.
• W2113118834 cites W1996727385 @default.
• W2113118834 cites W2007985281 @default.
• W2113118834 cites W2016620406 @default.
• W2113118834 cites W2027017286 @default.
• W2113118834 cites W2028850470 @default.
• W2113118834 cites W2034568739 @default.
• W2113118834 cites W2040732710 @default.
• W2113118834 cites W2045760616 @default.
• W2113118834 cites W2049111734 @default.
• W2113118834 cites W2076933906 @default.
• W2113118834 cites W2083808187 @default.
• W2113118834 cites W2093030508 @default.
• W2113118834 cites W2093382562 @default.
• W2113118834 cites W2098576362 @default.
• W2113118834 cites W2101023957 @default.
• W2113118834 cites W2107271640 @default.
• W2113118834 cites W2111344124 @default.
• W2113118834 cites W2111572642 @default.
• W2113118834 cites W2119819266 @default.
• W2113118834 cites W2128287083 @default.
• W2113118834 cites W2128444567 @default.
• W2113118834 cites W2130487806 @default.
• W2113118834 cites W2142834431 @default.
• W2113118834 cites W2150604056 @default.
• W2113118834 cites W2151523738 @default.
• W2113118834 cites W2152927547 @default.
• W2113118834 cites W2153375639 @default.
• W2113118834 cites W2153885085 @default.
• W2113118834 cites W2153906746 @default.
• W2113118834 cites W2156805553 @default.
• W2113118834 cites W2160934269 @default.
• W2113118834 cites W2162530578 @default.
• W2113118834 cites W2164881700 @default.
• W2113118834 cites W2168546972 @default.
• W2113118834 cites W2177584712 @default.
• W2113118834 cites W3024371187 @default.
• W2113118834 doi "https://doi.org/10.1186/1756-3305-4-5" @default.
• W2113118834 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3035027" @default.
• W2113118834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21226942" @default.
• W2113118834 hasPublicationYear "2011" @default.
• W2113118834 type Work @default.
• W2113118834 sameAs 2113118834 @default.
• W2113118834 citedByCount "163" @default.
• W2113118834 countsByYear W21131188342012 @default.
• W2113118834 countsByYear W21131188342013 @default.
• W2113118834 countsByYear W21131188342014 @default.
• W2113118834 countsByYear W21131188342015 @default.
• W2113118834 countsByYear W21131188342016 @default.
• W2113118834 countsByYear W21131188342017 @default.
• W2113118834 countsByYear W21131188342018 @default.
• W2113118834 countsByYear W21131188342019 @default.
• W2113118834 countsByYear W21131188342020 @default.
• W2113118834 countsByYear W21131188342021 @default.
• W2113118834 countsByYear W21131188342022 @default.
• W2113118834 countsByYear W21131188342023 @default.
• W2113118834 crossrefType "journal-article" @default.
• W2113118834 hasAuthorship W2113118834A5003178305 @default.
• W2113118834 hasAuthorship W2113118834A5013253015 @default.
• W2113118834 hasAuthorship W2113118834A5016910715 @default.
• W2113118834 hasAuthorship W2113118834A5039015276 @default.
• W2113118834 hasAuthorship W2113118834A5040776114 @default.
• W2113118834 hasAuthorship W2113118834A5044353413 @default.
• W2113118834 hasAuthorship W2113118834A5047273983 @default.
• W2113118834 hasAuthorship W2113118834A5048754510 @default.
• W2113118834 hasAuthorship W2113118834A5050619071 @default.
• W2113118834 hasAuthorship W2113118834A5067579923 @default.
• W2113118834 hasAuthorship W2113118834A5076805029 @default.
• W2113118834 hasAuthorship W2113118834A5079504528 @default.
• W2113118834 hasAuthorship W2113118834A5081238138 @default.
• W2113118834 hasBestOaLocation W21131188341 @default.
• W2113118834 hasConcept C104317684 @default.
• W2113118834 hasConcept C144024400 @default.
• W2113118834 hasConcept C149923435 @default.
• W2113118834 hasConcept C159047783 @default.
• W2113118834 hasConcept C161176658 @default.

• next