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• W2113123168 abstract "We characterized C-type retroviruses expressed in the pancreatic beta-cells of non-obese diabetic (NOD) mice by immunohistochemical techniques and by inhibiting the production of viral particles using antisense oligonucleotides. Some cells in the pancreatic islets from both NOD and diabetes-resistant NOD-related mice (NON) reacted with a monoclonal antibody directed against the envelope protein(s) of polytropic viruses. On the other hand, NOD islet cells also showed strong immunoreactivity with an anti-gag protein monoclonal antibody and another anti-envelope protein(s) monoclonal antibody that is specific for xenotropic viruses. In antisense oligodeoxynucleotide inhibition assays, a xenotropic virus-specific phosphorothionate-particles antisense oligodeoxynucleotide significantly inhibited the occurrence of C-type virus particles in NOD mouse islet beta-cells. Therefore, C-type retrovirus-like particles expressed in NOD mouse pancreatic beta-cells were considered to be endogenous xenotropic virus. The expression of the xenotropic viral genome may be involved in the pathogenesis of the diabetic syndrome in NOD mice." @default.
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• W2113123168 date "1998-01-01" @default.
• W2113123168 modified "2023-10-16" @default.
• W2113123168 title "Detection of endogenous retrovirus antigens in NOD mouse pancreatic <i>β</i>-cells" @default.
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• W2113123168 doi "https://doi.org/10.1258/002367798780559464" @default.
• W2113123168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9481699" @default.
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