Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113124851> ?p ?o ?g. }
- W2113124851 endingPage "8" @default.
- W2113124851 startingPage "8" @default.
- W2113124851 abstract "Ewing's sarcoma family tumors are a good example of how genome research has advanced our understanding of the molecular pathogenesis of an otherwise enigmatic disease. This group of embryonal bone tumors is characterized by the expression of a chimeric ETS-family oncogene, predominantly EWS/FLI1. There is now convincing evidence for a mesenchymal descent from an early pluripotent progenitor. EWS/FLI1 has been shown to drive proliferation of Ewing's sarcoma cells and block most of the differentiation potential except for a partial neural gene expression program. The EWS/FLI1 fusion protein acts mainly as a gene activator, directly interacting with chromatin at two kinds of binding site: distant enhancers enriched in GGAA microsatellites, and proximal promoters containing classical ETS-binding motifs and recognition motifs for other transcription factors. EWS/FLI1 also represses a large number of genes, mainly indirectly, presumably by altering microRNA expression and epigenetic mechanisms, and potentially affecting post-transcriptional gene regulation. Modulation of EWS/FLI1 expression is not only a desirable therapeutic goal, but may also occur under physiological conditions and influence the course of the disease." @default.
- W2113124851 created "2016-06-24" @default.
- W2113124851 creator A5028542112 @default.
- W2113124851 date "2010-01-01" @default.
- W2113124851 modified "2023-10-03" @default.
- W2113124851 title "Downstream EWS/FLI1 - upstream Ewing's sarcoma" @default.
- W2113124851 cites W1519034206 @default.
- W2113124851 cites W1578457275 @default.
- W2113124851 cites W1785897759 @default.
- W2113124851 cites W1973195150 @default.
- W2113124851 cites W1973770222 @default.
- W2113124851 cites W1984009890 @default.
- W2113124851 cites W1985338503 @default.
- W2113124851 cites W1988348701 @default.
- W2113124851 cites W1991951536 @default.
- W2113124851 cites W1995745247 @default.
- W2113124851 cites W1996665915 @default.
- W2113124851 cites W1996965392 @default.
- W2113124851 cites W1999748111 @default.
- W2113124851 cites W2002435899 @default.
- W2113124851 cites W2005341508 @default.
- W2113124851 cites W2007438323 @default.
- W2113124851 cites W2008679675 @default.
- W2113124851 cites W2017639069 @default.
- W2113124851 cites W2019142009 @default.
- W2113124851 cites W2021466685 @default.
- W2113124851 cites W2022352188 @default.
- W2113124851 cites W2023566473 @default.
- W2113124851 cites W2025989401 @default.
- W2113124851 cites W2027739413 @default.
- W2113124851 cites W2027899965 @default.
- W2113124851 cites W2030988924 @default.
- W2113124851 cites W2033392236 @default.
- W2113124851 cites W2041757531 @default.
- W2113124851 cites W2042155367 @default.
- W2113124851 cites W2045489734 @default.
- W2113124851 cites W2047058979 @default.
- W2113124851 cites W2057106443 @default.
- W2113124851 cites W2060123591 @default.
- W2113124851 cites W2065976494 @default.
- W2113124851 cites W2066280610 @default.
- W2113124851 cites W2068402552 @default.
- W2113124851 cites W2069351898 @default.
- W2113124851 cites W2082138815 @default.
- W2113124851 cites W2087253247 @default.
- W2113124851 cites W2090915824 @default.
- W2113124851 cites W2092784915 @default.
- W2113124851 cites W2101127767 @default.
- W2113124851 cites W2103571364 @default.
- W2113124851 cites W2105542427 @default.
- W2113124851 cites W2106637101 @default.
- W2113124851 cites W2107999044 @default.
- W2113124851 cites W2108696643 @default.
- W2113124851 cites W2117936052 @default.
- W2113124851 cites W2127975227 @default.
- W2113124851 cites W2134070848 @default.
- W2113124851 cites W2136182072 @default.
- W2113124851 cites W2136333374 @default.
- W2113124851 cites W2145051016 @default.
- W2113124851 cites W2147598399 @default.
- W2113124851 cites W2151444534 @default.
- W2113124851 cites W2151526351 @default.
- W2113124851 cites W2160175915 @default.
- W2113124851 cites W2161444433 @default.
- W2113124851 cites W2162611692 @default.
- W2113124851 cites W2163374376 @default.
- W2113124851 cites W2164937682 @default.
- W2113124851 cites W2166885657 @default.
- W2113124851 cites W2325613032 @default.
- W2113124851 cites W2411523234 @default.
- W2113124851 doi "https://doi.org/10.1186/gm129" @default.
- W2113124851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2829933" @default.
- W2113124851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20156317" @default.
- W2113124851 hasPublicationYear "2010" @default.
- W2113124851 type Work @default.
- W2113124851 sameAs 2113124851 @default.
- W2113124851 citedByCount "51" @default.
- W2113124851 countsByYear W21131248512012 @default.
- W2113124851 countsByYear W21131248512013 @default.
- W2113124851 countsByYear W21131248512014 @default.
- W2113124851 countsByYear W21131248512015 @default.
- W2113124851 countsByYear W21131248512016 @default.
- W2113124851 countsByYear W21131248512017 @default.
- W2113124851 countsByYear W21131248512018 @default.
- W2113124851 countsByYear W21131248512020 @default.
- W2113124851 countsByYear W21131248512021 @default.
- W2113124851 countsByYear W21131248512022 @default.
- W2113124851 countsByYear W21131248512023 @default.
- W2113124851 crossrefType "journal-article" @default.
- W2113124851 hasAuthorship W2113124851A5028542112 @default.
- W2113124851 hasBestOaLocation W21131248511 @default.
- W2113124851 hasConcept C101762097 @default.
- W2113124851 hasConcept C104317684 @default.
- W2113124851 hasConcept C111936080 @default.
- W2113124851 hasConcept C150194340 @default.
- W2113124851 hasConcept C165864922 @default.
- W2113124851 hasConcept C2777937962 @default.
- W2113124851 hasConcept C2781018059 @default.