FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113125265> ?p ?o ?g. }

• W2113125265 endingPage "5398" @default.
• W2113125265 startingPage "5389" @default.
• W2113125265 abstract "Abstract Poly(ADP-ribose) (PAR) polymerase 1 (PARP1) is activated by DNA single-strand breaks (SSB) or at stalled replication forks to facilitate DNA repair. Inhibitors of PARP efficiently kill breast, ovarian, or prostate tumors in patients carrying hereditary mutations in the homologous recombination (HR) genes BRCA1 or BRCA2 through synthetic lethality. Here, we surprisingly show that PARP1 is hyperactivated in replicating BRCA2-defective cells. PARP1 hyperactivation is explained by the defect in HR as shRNA depletion of RAD54, RAD52, BLM, WRN, and XRCC3 proteins, which we here show are all essential for efficient HR and also caused PARP hyperactivation and correlated with an increased sensitivity to PARP inhibitors. BRCA2-defective cells were not found to have increased levels of SSBs, and PAR polymers formed in HR-defective cells do not colocalize to replication protein A or γH2AX, excluding the possibility that PARP hyperactivity is due to increased SSB repair or PARP induced at damaged replication forks. Resistance to PARP inhibitors can occur through genetic reversion in the BRCA2 gene. Here, we report that PARP inhibitor–resistant BRCA2-mutant cells revert back to normal levels of PARP activity. We speculate that the reason for the sensitivity of HR-defective cells to PARP inhibitors is related to the hyperactivated PARP1 in these cells. Furthermore, the presence of PAR polymers can be used to identify HR-defective cells that are sensitive to PARP inhibitors, which may be potential biomarkers. Cancer Res; 70(13); 5389–98. ©2010 AACR." @default.
• W2113125265 created "2016-06-24" @default.
• W2113125265 creator A5000300151 @default.
• W2113125265 creator A5008236884 @default.
• W2113125265 creator A5010448733 @default.
• W2113125265 creator A5024881638 @default.
• W2113125265 creator A5027062405 @default.
• W2113125265 creator A5029296072 @default.
• W2113125265 creator A5059215689 @default.
• W2113125265 creator A5061232025 @default.
• W2113125265 creator A5068535825 @default.
• W2113125265 creator A5089936871 @default.
• W2113125265 date "2010-06-30" @default.
• W2113125265 modified "2023-09-26" @default.
• W2113125265 title "Poly(ADP-Ribose) Polymerase Is Hyperactivated in Homologous Recombination–Defective Cells" @default.
• W2113125265 cites W1964417205 @default.
• W2113125265 cites W1966479600 @default.
• W2113125265 cites W1968960110 @default.
• W2113125265 cites W1970184435 @default.
• W2113125265 cites W1973268287 @default.
• W2113125265 cites W1976385056 @default.
• W2113125265 cites W1988638876 @default.
• W2113125265 cites W2002385818 @default.
• W2113125265 cites W2009007206 @default.
• W2113125265 cites W2009374460 @default.
• W2113125265 cites W2010456654 @default.
• W2113125265 cites W2014150894 @default.
• W2113125265 cites W2026405645 @default.
• W2113125265 cites W2027379868 @default.
• W2113125265 cites W2033204568 @default.
• W2113125265 cites W2038712263 @default.
• W2113125265 cites W2049921243 @default.
• W2113125265 cites W2050164541 @default.
• W2113125265 cites W2056848326 @default.
• W2113125265 cites W2062739292 @default.
• W2113125265 cites W2065849886 @default.
• W2113125265 cites W2067117419 @default.
• W2113125265 cites W2068140359 @default.
• W2113125265 cites W2071137315 @default.
• W2113125265 cites W2084772885 @default.
• W2113125265 cites W2092629964 @default.
• W2113125265 cites W2099627146 @default.
• W2113125265 cites W2103770333 @default.
• W2113125265 cites W2114787582 @default.
• W2113125265 cites W2115607227 @default.
• W2113125265 cites W2124407395 @default.
• W2113125265 cites W2136367213 @default.
• W2113125265 cites W2146309825 @default.
• W2113125265 cites W2147126714 @default.
• W2113125265 cites W2159310233 @default.
• W2113125265 cites W2168891239 @default.
• W2113125265 cites W2171972386 @default.
• W2113125265 cites W2334990949 @default.
• W2113125265 doi "https://doi.org/10.1158/0008-5472.can-09-4716" @default.
• W2113125265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20551068" @default.
• W2113125265 hasPublicationYear "2010" @default.
• W2113125265 type Work @default.
• W2113125265 sameAs 2113125265 @default.
• W2113125265 citedByCount "194" @default.
• W2113125265 countsByYear W21131252652012 @default.
• W2113125265 countsByYear W21131252652013 @default.
• W2113125265 countsByYear W21131252652014 @default.
• W2113125265 countsByYear W21131252652015 @default.
• W2113125265 countsByYear W21131252652016 @default.
• W2113125265 countsByYear W21131252652017 @default.
• W2113125265 countsByYear W21131252652018 @default.
• W2113125265 countsByYear W21131252652019 @default.
• W2113125265 countsByYear W21131252652020 @default.
• W2113125265 countsByYear W21131252652021 @default.
• W2113125265 countsByYear W21131252652022 @default.
• W2113125265 countsByYear W21131252652023 @default.
• W2113125265 crossrefType "journal-article" @default.
• W2113125265 hasAuthorship W2113125265A5000300151 @default.
• W2113125265 hasAuthorship W2113125265A5008236884 @default.
• W2113125265 hasAuthorship W2113125265A5010448733 @default.
• W2113125265 hasAuthorship W2113125265A5024881638 @default.
• W2113125265 hasAuthorship W2113125265A5027062405 @default.
• W2113125265 hasAuthorship W2113125265A5029296072 @default.
• W2113125265 hasAuthorship W2113125265A5059215689 @default.
• W2113125265 hasAuthorship W2113125265A5061232025 @default.
• W2113125265 hasAuthorship W2113125265A5068535825 @default.
• W2113125265 hasAuthorship W2113125265A5089936871 @default.
• W2113125265 hasConcept C102744134 @default.
• W2113125265 hasConcept C134935766 @default.
• W2113125265 hasConcept C153911025 @default.
• W2113125265 hasConcept C182979987 @default.
• W2113125265 hasConcept C2778366672 @default.
• W2113125265 hasConcept C2778480876 @default.
• W2113125265 hasConcept C2779138821 @default.
• W2113125265 hasConcept C2779962180 @default.
• W2113125265 hasConcept C2781312401 @default.
• W2113125265 hasConcept C502942594 @default.
• W2113125265 hasConcept C54355233 @default.
• W2113125265 hasConcept C552990157 @default.
• W2113125265 hasConcept C82381507 @default.
• W2113125265 hasConcept C86803240 @default.
• W2113125265 hasConceptScore W2113125265C102744134 @default.
• W2113125265 hasConceptScore W2113125265C134935766 @default.

• next