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- W2113126534 startingPage "1208" @default.
- W2113126534 abstract "Chromosome replication occurs precisely once during the cell cycle of almost all eukaryotic cells, and is a highly complex process that is still understood relatively poorly. Two conserved kinases called Cdc7 (cell division cycle 7) and cyclin-dependent kinase (CDK) are required to establish replication forks during the initiation of chromosome replication, and a key feature of this process is the activation of the replicative DNA helicase in situ at each origin of DNA replication. A series of recent studies has shed new light on the targets of Cdc7 and CDK, indicating that chromosome replication probably initiates by a fundamentally similar mechanism in all eukaryotes." @default.
- W2113126534 created "2016-06-24" @default.
- W2113126534 creator A5073735040 @default.
- W2113126534 date "2010-06-15" @default.
- W2113126534 modified "2023-10-16" @default.
- W2113126534 title "How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?" @default.
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- W2113126534 doi "https://doi.org/10.1101/gad.1933010" @default.
- W2113126534 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2885657" @default.
- W2113126534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20551170" @default.
- W2113126534 hasPublicationYear "2010" @default.
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