Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113126716> ?p ?o ?g. }
- W2113126716 endingPage "18125" @default.
- W2113126716 startingPage "18120" @default.
- W2113126716 abstract "Mutations in the contactin-associated protein 2 ( CNTNAP2 ) gene encoding CASPR2, a neurexin-related cell-adhesion molecule, predispose to autism, but the function of CASPR2 in neural circuit assembly remains largely unknown. In a knockdown survey of autism candidate genes, we found that CASPR2 is required for normal development of neural networks. RNAi-mediated knockdown of CASPR2 produced a cell-autonomous decrease in dendritic arborization and spine development in pyramidal neurons, leading to a global decline in excitatory and inhibitory synapse numbers and a decrease in synaptic transmission without a detectable change in the properties of these synapses. Our data suggest that in addition to the previously described role of CASPR2 in mature neurons, where CASPR2 organizes nodal microdomains of myelinated axons, CASPR2 performs an earlier organizational function in developing neurons that is essential for neural circuit assembly and operates coincident with the time of autism spectrum disorder (ASD) pathogenesis." @default.
- W2113126716 created "2016-06-24" @default.
- W2113126716 creator A5003413224 @default.
- W2113126716 creator A5021671972 @default.
- W2113126716 creator A5023143600 @default.
- W2113126716 creator A5041585906 @default.
- W2113126716 creator A5061921730 @default.
- W2113126716 creator A5063684725 @default.
- W2113126716 date "2012-10-16" @default.
- W2113126716 modified "2023-10-16" @default.
- W2113126716 title "Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development" @default.
- W2113126716 cites W1976358763 @default.
- W2113126716 cites W1979334130 @default.
- W2113126716 cites W1979870422 @default.
- W2113126716 cites W1983927922 @default.
- W2113126716 cites W1988011192 @default.
- W2113126716 cites W1988094938 @default.
- W2113126716 cites W1991145039 @default.
- W2113126716 cites W1997681700 @default.
- W2113126716 cites W1998127228 @default.
- W2113126716 cites W2002078086 @default.
- W2113126716 cites W2003479128 @default.
- W2113126716 cites W2003895747 @default.
- W2113126716 cites W2004104083 @default.
- W2113126716 cites W2007508740 @default.
- W2113126716 cites W2010164205 @default.
- W2113126716 cites W2012203722 @default.
- W2113126716 cites W2012411442 @default.
- W2113126716 cites W2020960495 @default.
- W2113126716 cites W2021035407 @default.
- W2113126716 cites W2022498096 @default.
- W2113126716 cites W2024297133 @default.
- W2113126716 cites W2032148110 @default.
- W2113126716 cites W2037995604 @default.
- W2113126716 cites W2041733763 @default.
- W2113126716 cites W2072624089 @default.
- W2113126716 cites W2073154969 @default.
- W2113126716 cites W2080036595 @default.
- W2113126716 cites W2080488750 @default.
- W2113126716 cites W2081005556 @default.
- W2113126716 cites W2090336874 @default.
- W2113126716 cites W2092825250 @default.
- W2113126716 cites W2095791306 @default.
- W2113126716 cites W2097049394 @default.
- W2113126716 cites W2098584548 @default.
- W2113126716 cites W2099756187 @default.
- W2113126716 cites W2113519237 @default.
- W2113126716 cites W2122971055 @default.
- W2113126716 cites W2127753140 @default.
- W2113126716 cites W2135802610 @default.
- W2113126716 cites W2147072282 @default.
- W2113126716 cites W2151915336 @default.
- W2113126716 cites W2152704739 @default.
- W2113126716 cites W2156134210 @default.
- W2113126716 cites W2165302477 @default.
- W2113126716 cites W2171804213 @default.
- W2113126716 doi "https://doi.org/10.1073/pnas.1216398109" @default.
- W2113126716 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3497786" @default.
- W2113126716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23074245" @default.
- W2113126716 hasPublicationYear "2012" @default.
- W2113126716 type Work @default.
- W2113126716 sameAs 2113126716 @default.
- W2113126716 citedByCount "192" @default.
- W2113126716 countsByYear W21131267162013 @default.
- W2113126716 countsByYear W21131267162014 @default.
- W2113126716 countsByYear W21131267162015 @default.
- W2113126716 countsByYear W21131267162016 @default.
- W2113126716 countsByYear W21131267162017 @default.
- W2113126716 countsByYear W21131267162018 @default.
- W2113126716 countsByYear W21131267162019 @default.
- W2113126716 countsByYear W21131267162020 @default.
- W2113126716 countsByYear W21131267162021 @default.
- W2113126716 countsByYear W21131267162022 @default.
- W2113126716 countsByYear W21131267162023 @default.
- W2113126716 crossrefType "journal-article" @default.
- W2113126716 hasAuthorship W2113126716A5003413224 @default.
- W2113126716 hasAuthorship W2113126716A5021671972 @default.
- W2113126716 hasAuthorship W2113126716A5023143600 @default.
- W2113126716 hasAuthorship W2113126716A5041585906 @default.
- W2113126716 hasAuthorship W2113126716A5061921730 @default.
- W2113126716 hasAuthorship W2113126716A5063684725 @default.
- W2113126716 hasBestOaLocation W21131267161 @default.
- W2113126716 hasConcept C104317684 @default.
- W2113126716 hasConcept C112592302 @default.
- W2113126716 hasConcept C127445978 @default.
- W2113126716 hasConcept C148762608 @default.
- W2113126716 hasConcept C16224149 @default.
- W2113126716 hasConcept C169760540 @default.
- W2113126716 hasConcept C170493617 @default.
- W2113126716 hasConcept C17077164 @default.
- W2113126716 hasConcept C173396325 @default.
- W2113126716 hasConcept C174884520 @default.
- W2113126716 hasConcept C197341189 @default.
- W2113126716 hasConcept C200170125 @default.
- W2113126716 hasConcept C2778162979 @default.
- W2113126716 hasConcept C2779790309 @default.
- W2113126716 hasConcept C54355233 @default.
- W2113126716 hasConcept C86803240 @default.