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- W2113126998 abstract "The selective activation of prodrug(s) in tumor tissues by exogenous enzyme(s) for cancer therapy can be accomplished by several ways, including gene-directed enzyme prodrug therapy (GDEPT), virus-directed enzyme prodrug therapy (VDEPT), and antibody-directed enzyme prodrug therapy (ADEPT). The central part of enzyme/prodrug cancer therapy is to deliver drug-activating enzyme gene or functional protein to tumor tissues, followed by systemic administration of a prodrug. Although each approach (GDEPT, VDEPT, and ADEPT) has been tested in clinical trials, there are some potential problems using the current delivery systems. In this article, disadvantages and advantages associated with each approach (GDEPT, VDEPT, and ADEPT) and future perspective for improving current systems are discussed." @default.
- W2113126998 created "2016-06-24" @default.
- W2113126998 creator A5011034688 @default.
- W2113126998 creator A5015339137 @default.
- W2113126998 date "2001-11-01" @default.
- W2113126998 modified "2023-10-17" @default.
- W2113126998 title "Strategies for enzyme/prodrug cancer therapy." @default.
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