FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113131381> ?p ?o ?g. }

• W2113131381 endingPage "31" @default.
• W2113131381 startingPage "23" @default.
• W2113131381 abstract "The Na+/I− symporter (NIS) is the plasma membrane glycoprotein that mediates the active uptake of I− in the thyroid, ie, the crucial first step in thyroid hormone biosynthesis. NIS also mediates I− uptake in other tissues, such as salivary glands, gastric mucosa, and lactating (but not nonlactating) mammary gland. The ability of thyroid cancer cells to actively transport I− via NIS provides a unique and effective delivery system to detect and target these cells for destruction with therapeutic doses of radioiodide. Breast cancer is the only malignancy other than thyroid cancer to have been shown to functionally express NIS endogenously. The considerable potential diagnostic and therapeutic use of radioiodide in breast cancer is currently being assessed. On the other hand, exogenous NIS gene transfer has successfully been carried out into a variety of other cell lines and tumors, including A375 human melanoma tumors, and SiHa cervix cancer, human glioma, and hepatoma cell lines. Most notably, significant radioiodine therapy results have been obtained in the NIS-transfected human prostatic adenocarcinoma cell line LNCaP and in NIS-transfected myeloma cells, both of which exhibited prolonged retention of radio iodide even in the absence of I− organification. The therapeutic potential of alternative NIS-transported radioisotopes with different decay properties and a shorter, physical half-life than 131I−, such as β-emitter 188Rhenium (188ReO4−) and α-emitter 211Astatine (211At−), has been evaluated. In conclusion, it is clear that the remarkable progress made in the last few years in the molecular characterization of NIS has created new opportunities for the development of diagnostic and therapeutic applications for NIS in nuclear medicine." @default.
• W2113131381 created "2016-06-24" @default.
• W2113131381 creator A5034610205 @default.
• W2113131381 creator A5049126875 @default.
• W2113131381 date "2004-01-01" @default.
• W2113131381 modified "2023-09-27" @default.
• W2113131381 title "The Na+/I− symporter (NIS): imaging and therapeutic applications" @default.
• W2113131381 cites W1491403843 @default.
• W2113131381 cites W1500162811 @default.
• W2113131381 cites W1944013674 @default.
• W2113131381 cites W1964366490 @default.
• W2113131381 cites W1967981106 @default.
• W2113131381 cites W1971603116 @default.
• W2113131381 cites W1978247129 @default.
• W2113131381 cites W1981123026 @default.
• W2113131381 cites W1986199849 @default.
• W2113131381 cites W1986513627 @default.
• W2113131381 cites W2002338610 @default.
• W2113131381 cites W2010481551 @default.
• W2113131381 cites W2024032842 @default.
• W2113131381 cites W2024650333 @default.
• W2113131381 cites W2026316938 @default.
• W2113131381 cites W2034083247 @default.
• W2113131381 cites W2043394193 @default.
• W2113131381 cites W2046061197 @default.
• W2113131381 cites W2048961545 @default.
• W2113131381 cites W2054970048 @default.
• W2113131381 cites W2060007614 @default.
• W2113131381 cites W2064022012 @default.
• W2113131381 cites W2064806925 @default.
• W2113131381 cites W2065003195 @default.
• W2113131381 cites W2065987736 @default.
• W2113131381 cites W2073690158 @default.
• W2113131381 cites W2082832566 @default.
• W2113131381 cites W2084810075 @default.
• W2113131381 cites W2086908173 @default.
• W2113131381 cites W2091590087 @default.
• W2113131381 cites W2097970915 @default.
• W2113131381 cites W2120223211 @default.
• W2113131381 cites W2138994122 @default.
• W2113131381 cites W2146870257 @default.
• W2113131381 cites W2153876645 @default.
• W2113131381 cites W2320378887 @default.
• W2113131381 cites W2329507162 @default.
• W2113131381 cites W2331426277 @default.
• W2113131381 cites W2334462662 @default.
• W2113131381 doi "https://doi.org/10.1053/j.semnuclmed.2003.09.004" @default.
• W2113131381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14735456" @default.
• W2113131381 hasPublicationYear "2004" @default.
• W2113131381 type Work @default.
• W2113131381 sameAs 2113131381 @default.
• W2113131381 citedByCount "90" @default.
• W2113131381 countsByYear W21131313812012 @default.
• W2113131381 countsByYear W21131313812013 @default.
• W2113131381 countsByYear W21131313812014 @default.
• W2113131381 countsByYear W21131313812015 @default.
• W2113131381 countsByYear W21131313812016 @default.
• W2113131381 countsByYear W21131313812017 @default.
• W2113131381 countsByYear W21131313812018 @default.
• W2113131381 countsByYear W21131313812019 @default.
• W2113131381 countsByYear W21131313812021 @default.
• W2113131381 countsByYear W21131313812022 @default.
• W2113131381 crossrefType "journal-article" @default.
• W2113131381 hasAuthorship W2113131381A5034610205 @default.
• W2113131381 hasAuthorship W2113131381A5049126875 @default.
• W2113131381 hasConcept C104317684 @default.
• W2113131381 hasConcept C120405084 @default.
• W2113131381 hasConcept C121608353 @default.
• W2113131381 hasConcept C126322002 @default.
• W2113131381 hasConcept C134018914 @default.
• W2113131381 hasConcept C149011108 @default.
• W2113131381 hasConcept C2779761222 @default.
• W2113131381 hasConcept C2780256643 @default.
• W2113131381 hasConcept C2780616701 @default.
• W2113131381 hasConcept C502942594 @default.
• W2113131381 hasConcept C526584372 @default.
• W2113131381 hasConcept C530470458 @default.
• W2113131381 hasConcept C55493867 @default.
• W2113131381 hasConcept C71924100 @default.
• W2113131381 hasConcept C86803240 @default.
• W2113131381 hasConceptScore W2113131381C104317684 @default.
• W2113131381 hasConceptScore W2113131381C120405084 @default.
• W2113131381 hasConceptScore W2113131381C121608353 @default.
• W2113131381 hasConceptScore W2113131381C126322002 @default.
• W2113131381 hasConceptScore W2113131381C134018914 @default.
• W2113131381 hasConceptScore W2113131381C149011108 @default.
• W2113131381 hasConceptScore W2113131381C2779761222 @default.
• W2113131381 hasConceptScore W2113131381C2780256643 @default.
• W2113131381 hasConceptScore W2113131381C2780616701 @default.
• W2113131381 hasConceptScore W2113131381C502942594 @default.
• W2113131381 hasConceptScore W2113131381C526584372 @default.
• W2113131381 hasConceptScore W2113131381C530470458 @default.
• W2113131381 hasConceptScore W2113131381C55493867 @default.
• W2113131381 hasConceptScore W2113131381C71924100 @default.
• W2113131381 hasConceptScore W2113131381C86803240 @default.
• W2113131381 hasIssue "1" @default.
• W2113131381 hasLocation W21131313811 @default.
• W2113131381 hasLocation W21131313812 @default.

• next