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- W2113137053 abstract "The effects of plutonium-239, an α-particle emitting radionuclide which deposits mainly in the lysosomes, on the activity of various lysosomal enzymes have been studied in rat liver. The effects observed have been compared with those produced by the β + γ radiation from colloidal gold-198. Following administration of 0.5 μCi polymeric239 Pu the specific activities of acid deoxyribonuclease and aryl sulphatase were increased by 30 days and remained elevated at 1 yr. β-Glucuronidase, acid β-glycerophosphatase, and cathepsin D showed increased specific acitivity at time intervals longer than 6 mo after injection of239 Pu. All the enzymes studied showed decreased sedimentability at 30 days but this returned to approximately normal limits at longer time intervals. In comparison the administration of 0.5 mCi198 Au colloid also caused increased specific activity of deoxyribonuclease II, β-glucuronidase, and acid β-glycerophosphatase, but did not decrease the enzyme sedimentabilities. It is concluded that at leas..." @default.
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- W2113137053 date "1974-09-01" @default.
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- W2113137053 title "The effect of internally deposited plutonium-239 on the lysosomes of rat liver." @default.
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