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- W2113139507 abstract "Rhodopsin is a specialized G protein–coupled receptor (GPCR) found in vertebrate rod cells. Absorption of light by its 11-cis retinal chromophore leads to rapid photochemical isomerization and receptor activation. Recent results from protein crystallography and NMR spectroscopy show how structural changes on the extracellular side of rhodopsin induced by retinal isomerization are coupled to the motion of membrane-spanning helices to create a G protein binding pocket on the intracellular side of the receptor. The signaling pathway provides a comprehensive explanation for the conservation of specific amino acids and structural motifs across the class A family of GPCRs, as well as for the conservation of selected residues within the visual receptor subfamily. The emerging model of activation indicates that, rather than being unique, the visual receptors provide a basis for understanding the common structural and dynamic elements in the class A GPCRs." @default.
- W2113139507 created "2016-06-24" @default.
- W2113139507 creator A5087656467 @default.
- W2113139507 date "2010-04-01" @default.
- W2113139507 modified "2023-09-25" @default.
- W2113139507 title "Structure and Activation of the Visual Pigment Rhodopsin" @default.
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- W2113139507 doi "https://doi.org/10.1146/annurev-biophys-101209-104901" @default.
- W2113139507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20192770" @default.
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