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- W2113141324 abstract "Abstract A new method of directed solution phase synthesis of polypeptides linked through iterative formation of disulfide bonds is reported. Four dodecapeptides were successfully ligated into a single 48 amino acid polypeptide using an N‐terminal Fmoc‐thiazolidine and a novel acidic silver trifluoromethanesulfonate thiazolidine hydrolysis to achieve efficient ligation in the presence of internal disulfide bonds. The approach allows the synthesis of homogeneous disulfide cross‐linked polypeptides that have application in gene delivery by undergoing a reductively triggered release of DNA. © 2012 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 98: 510–517, 2012." @default.
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- W2113141324 date "2012-01-01" @default.
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- W2113141324 title "Synthesis of homogenous disulfide cross-linked polypeptides by iterative reducible ligation" @default.
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- W2113141324 doi "https://doi.org/10.1002/bip.22117" @default.
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