FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113143246> ?p ?o ?g. }

• W2113143246 endingPage "1202" @default.
• W2113143246 startingPage "1198" @default.
• W2113143246 abstract "Abstract Purpose: The melanoma differentiation-associated gene-7 (MDA-7) protein, also known as interleukin (IL)-24, is a novel candidate of tumor suppressor that can induce apoptosis experimentally in a variety of human malignant cells including lung cancer cells. However, only one clinical study has documented that MDA-7/IL-24 expression is down-regulated with progression of melanoma. Thus, the present study was conducted to assess the clinical significance of MDA-7/IL-24 expression in non–small cell lung cancer. Experimental Design: A total of 183 consecutive patients with resected pathologic stage I-IIIA, non–small cell lung cancer were retrospectively reviewed, and immunohistochemical staining was used to detect MDA-7/IL-24 expression. Results: MDA-7/IL-24 expression was high in 97 (53.0%) patients and low in the other patients. There was no significant correlation between MDA-7/IL-24 status and any patients' characteristic including pathologic stage. There was no significant difference in tumor angiogenesis or proliferative activity according to MDA-7/IL-24 status, but MDA-7/IL-24-high adenocarcinoma showed a significantly higher incidence of apoptotic tumor cell death than MDA-7/IL-24-low adenocarcinoma. MDA-7/IL-24-high patients seemed to show a favorable postoperative prognosis as compared with MDA-7/IL-24-low patients (5-year survival rates, 75.9% and 62.0%, respectively), although the difference did not reach a statistical significance (P = 0.061). Subset analyses showed that positive MDA-7/IL-24 expression was a significant factor to predict a favorable prognosis in adenocarcinoma (P = 0.033), which was confirmed by a multivariate analysis; there was no difference in the prognosis according to MDA-7/IL-24 status in squamous cell carcinoma. Conclusions: MDA-7/IL-24 status was a significant prognostic factor in lung adenocarcinoma, not in lung squamous cell carcinoma." @default.
• W2113143246 created "2016-06-24" @default.
• W2113143246 creator A5015471387 @default.
• W2113143246 creator A5017546556 @default.
• W2113143246 creator A5029969715 @default.
• W2113143246 creator A5035690333 @default.
• W2113143246 creator A5040592706 @default.
• W2113143246 creator A5049226902 @default.
• W2113143246 creator A5053475533 @default.
• W2113143246 creator A5055183108 @default.
• W2113143246 creator A5071263763 @default.
• W2113143246 creator A5078353543 @default.
• W2113143246 date "2005-02-01" @default.
• W2113143246 modified "2023-10-16" @default.
• W2113143246 title "Expression of MDA-7/IL-24 and Its Clinical Significance in Resected Non–Small Cell Lung Cancer" @default.
• W2113143246 cites W1585683447 @default.
• W2113143246 cites W1983366532 @default.
• W2113143246 cites W1988156896 @default.
• W2113143246 cites W1989513172 @default.
• W2113143246 cites W1993312546 @default.
• W2113143246 cites W2001401716 @default.
• W2113143246 cites W2042358211 @default.
• W2113143246 cites W2093117205 @default.
• W2113143246 cites W2101980928 @default.
• W2113143246 cites W2145653040 @default.
• W2113143246 cites W2278422521 @default.
• W2113143246 cites W2321501275 @default.
• W2113143246 cites W2323327334 @default.
• W2113143246 cites W4242089499 @default.
• W2113143246 cites W86920939 @default.
• W2113143246 cites W92559662 @default.
• W2113143246 doi "https://doi.org/10.1158/1078-0432.1198.11.3" @default.
• W2113143246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15709189" @default.
• W2113143246 hasPublicationYear "2005" @default.
• W2113143246 type Work @default.
• W2113143246 sameAs 2113143246 @default.
• W2113143246 citedByCount "17" @default.
• W2113143246 countsByYear W21131432462012 @default.
• W2113143246 countsByYear W21131432462014 @default.
• W2113143246 countsByYear W21131432462016 @default.
• W2113143246 countsByYear W21131432462019 @default.
• W2113143246 countsByYear W21131432462020 @default.
• W2113143246 countsByYear W21131432462021 @default.
• W2113143246 crossrefType "journal-article" @default.
• W2113143246 hasAuthorship W2113143246A5015471387 @default.
• W2113143246 hasAuthorship W2113143246A5017546556 @default.
• W2113143246 hasAuthorship W2113143246A5029969715 @default.
• W2113143246 hasAuthorship W2113143246A5035690333 @default.
• W2113143246 hasAuthorship W2113143246A5040592706 @default.
• W2113143246 hasAuthorship W2113143246A5049226902 @default.
• W2113143246 hasAuthorship W2113143246A5053475533 @default.
• W2113143246 hasAuthorship W2113143246A5055183108 @default.
• W2113143246 hasAuthorship W2113143246A5071263763 @default.
• W2113143246 hasAuthorship W2113143246A5078353543 @default.
• W2113143246 hasBestOaLocation W21131432461 @default.
• W2113143246 hasConcept C121608353 @default.
• W2113143246 hasConcept C126322002 @default.
• W2113143246 hasConcept C142724271 @default.
• W2113143246 hasConcept C143998085 @default.
• W2113143246 hasConcept C190283241 @default.
• W2113143246 hasConcept C204232928 @default.
• W2113143246 hasConcept C2776256026 @default.
• W2113143246 hasConcept C2777658100 @default.
• W2113143246 hasConcept C2779256057 @default.
• W2113143246 hasConcept C2780394083 @default.
• W2113143246 hasConcept C2781182431 @default.
• W2113143246 hasConcept C502942594 @default.
• W2113143246 hasConcept C55493867 @default.
• W2113143246 hasConcept C63363279 @default.
• W2113143246 hasConcept C65409693 @default.
• W2113143246 hasConcept C71924100 @default.
• W2113143246 hasConcept C86803240 @default.
• W2113143246 hasConceptScore W2113143246C121608353 @default.
• W2113143246 hasConceptScore W2113143246C126322002 @default.
• W2113143246 hasConceptScore W2113143246C142724271 @default.
• W2113143246 hasConceptScore W2113143246C143998085 @default.
• W2113143246 hasConceptScore W2113143246C190283241 @default.
• W2113143246 hasConceptScore W2113143246C204232928 @default.
• W2113143246 hasConceptScore W2113143246C2776256026 @default.
• W2113143246 hasConceptScore W2113143246C2777658100 @default.
• W2113143246 hasConceptScore W2113143246C2779256057 @default.
• W2113143246 hasConceptScore W2113143246C2780394083 @default.
• W2113143246 hasConceptScore W2113143246C2781182431 @default.
• W2113143246 hasConceptScore W2113143246C502942594 @default.
• W2113143246 hasConceptScore W2113143246C55493867 @default.
• W2113143246 hasConceptScore W2113143246C63363279 @default.
• W2113143246 hasConceptScore W2113143246C65409693 @default.
• W2113143246 hasConceptScore W2113143246C71924100 @default.
• W2113143246 hasConceptScore W2113143246C86803240 @default.
• W2113143246 hasIssue "3" @default.
• W2113143246 hasLocation W21131432461 @default.
• W2113143246 hasLocation W21131432462 @default.
• W2113143246 hasOpenAccess W2113143246 @default.
• W2113143246 hasPrimaryLocation W21131432461 @default.
• W2113143246 hasRelatedWork W1606053986 @default.
• W2113143246 hasRelatedWork W2066429436 @default.
• W2113143246 hasRelatedWork W2071889249 @default.
• W2113143246 hasRelatedWork W2116706847 @default.

• next