FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113143775> ?p ?o ?g. }

• W2113143775 endingPage "715" @default.
• W2113143775 startingPage "709" @default.
• W2113143775 abstract "ABSTRACT Mutations in several subgenomic regions have been implicated in influencing response to interferon therapy; however, a comprehensive picture of Indian patients was lacking. Based on the viral load and clinical factors, 10 out of 15 patients were found to be complete responders, whereas 5 patients were nonresponders. The pretreatment viral RNA load of the patients was found to be between 5.20 and 6.13 log 10 IU/ml, which eventually fell to 2.77 log 10 IU/ml after 24 weeks of treatment, whereas in the case of nonresponders, the average was 5.38 log 10 IU/ml. In order to study the influence of the hepatitis C virus genotype on the response to interferon therapy, the 5′ untranslated region sequences of the samples were analyzed, which showed that genotype 3 patients responded better than genotype 1 patients. Additionally, the mutations in the interferon sensitivity-determining region (ISDR) of the NS5A protein and the double-stranded RNA-activated protein kinase-eukaryotic initiation factor 2 alpha phosphorylation homology domain (PePHD) of the E2 envelope protein, before and after treatment, were compared with nonresponder prototype J. Although, no clear correlation was found in the case of the mutated ISDR, some significant changes in residues were observed in the PePHD region, which could be helpful in understanding the molecular basis of resistance to therapy. Interestingly, analysis of the quasispecies variations showed a change in genotype in one sample during treatment, which might have contributed to the resistance. The results suggest that the mutations in different regions of the viral genome might have a concerted effect on the response to interferon therapy." @default.
• W2113143775 created "2016-06-24" @default.
• W2113143775 creator A5012179116 @default.
• W2113143775 creator A5016476211 @default.
• W2113143775 creator A5044087184 @default.
• W2113143775 creator A5053056600 @default.
• W2113143775 creator A5059801211 @default.
• W2113143775 creator A5072901336 @default.
• W2113143775 creator A5086243160 @default.
• W2113143775 date "2006-03-01" @default.
• W2113143775 modified "2023-09-24" @default.
• W2113143775 title "Analysis of Mutations within the 5′ Untranslated Region, Interferon Sensitivity Region, and PePHD Region as a Function of Response to Interferon Therapy in Hepatitis C Virus-Infected Patients in India" @default.
• W2113143775 cites W1993183790 @default.
• W2113143775 cites W1994364955 @default.
• W2113143775 cites W2006309458 @default.
• W2113143775 cites W2036364486 @default.
• W2113143775 cites W2039582463 @default.
• W2113143775 cites W2050096196 @default.
• W2113143775 cites W2059457521 @default.
• W2113143775 cites W2073243952 @default.
• W2113143775 cites W2073700643 @default.
• W2113143775 cites W2075468626 @default.
• W2113143775 cites W2079610740 @default.
• W2113143775 cites W2085637417 @default.
• W2113143775 cites W2094315296 @default.
• W2113143775 cites W2111493670 @default.
• W2113143775 cites W2121242678 @default.
• W2113143775 cites W2121887853 @default.
• W2113143775 cites W2122987848 @default.
• W2113143775 cites W2143161707 @default.
• W2113143775 cites W2150640672 @default.
• W2113143775 cites W2158697492 @default.
• W2113143775 cites W2162234181 @default.
• W2113143775 cites W2730406801 @default.
• W2113143775 doi "https://doi.org/10.1128/jcm.44.3.709-715.2006" @default.
• W2113143775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1393096" @default.
• W2113143775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16517843" @default.
• W2113143775 hasPublicationYear "2006" @default.
• W2113143775 type Work @default.
• W2113143775 sameAs 2113143775 @default.
• W2113143775 citedByCount "20" @default.
• W2113143775 countsByYear W21131437752012 @default.
• W2113143775 countsByYear W21131437752014 @default.
• W2113143775 countsByYear W21131437752015 @default.
• W2113143775 countsByYear W21131437752016 @default.
• W2113143775 countsByYear W21131437752018 @default.
• W2113143775 crossrefType "journal-article" @default.
• W2113143775 hasAuthorship W2113143775A5012179116 @default.
• W2113143775 hasAuthorship W2113143775A5016476211 @default.
• W2113143775 hasAuthorship W2113143775A5044087184 @default.
• W2113143775 hasAuthorship W2113143775A5053056600 @default.
• W2113143775 hasAuthorship W2113143775A5059801211 @default.
• W2113143775 hasAuthorship W2113143775A5072901336 @default.
• W2113143775 hasAuthorship W2113143775A5086243160 @default.
• W2113143775 hasBestOaLocation W21131437751 @default.
• W2113143775 hasConcept C104317684 @default.
• W2113143775 hasConcept C135763542 @default.
• W2113143775 hasConcept C142462285 @default.
• W2113143775 hasConcept C14500911 @default.
• W2113143775 hasConcept C159047783 @default.
• W2113143775 hasConcept C2522874641 @default.
• W2113143775 hasConcept C2776178377 @default.
• W2113143775 hasConcept C2776408679 @default.
• W2113143775 hasConcept C2777103181 @default.
• W2113143775 hasConcept C2781463415 @default.
• W2113143775 hasConcept C2909179924 @default.
• W2113143775 hasConcept C54355233 @default.
• W2113143775 hasConcept C67705224 @default.
• W2113143775 hasConcept C86803240 @default.
• W2113143775 hasConcept C89604277 @default.
• W2113143775 hasConceptScore W2113143775C104317684 @default.
• W2113143775 hasConceptScore W2113143775C135763542 @default.
• W2113143775 hasConceptScore W2113143775C142462285 @default.
• W2113143775 hasConceptScore W2113143775C14500911 @default.
• W2113143775 hasConceptScore W2113143775C159047783 @default.
• W2113143775 hasConceptScore W2113143775C2522874641 @default.
• W2113143775 hasConceptScore W2113143775C2776178377 @default.
• W2113143775 hasConceptScore W2113143775C2776408679 @default.
• W2113143775 hasConceptScore W2113143775C2777103181 @default.
• W2113143775 hasConceptScore W2113143775C2781463415 @default.
• W2113143775 hasConceptScore W2113143775C2909179924 @default.
• W2113143775 hasConceptScore W2113143775C54355233 @default.
• W2113143775 hasConceptScore W2113143775C67705224 @default.
• W2113143775 hasConceptScore W2113143775C86803240 @default.
• W2113143775 hasConceptScore W2113143775C89604277 @default.
• W2113143775 hasIssue "3" @default.
• W2113143775 hasLocation W21131437751 @default.
• W2113143775 hasLocation W21131437752 @default.
• W2113143775 hasLocation W21131437753 @default.
• W2113143775 hasOpenAccess W2113143775 @default.
• W2113143775 hasPrimaryLocation W21131437751 @default.
• W2113143775 hasRelatedWork W1980805512 @default.
• W2113143775 hasRelatedWork W1997243556 @default.
• W2113143775 hasRelatedWork W2029008013 @default.
• W2113143775 hasRelatedWork W2105599476 @default.
• W2113143775 hasRelatedWork W2152450239 @default.
• W2113143775 hasRelatedWork W2162064861 @default.
• W2113143775 hasRelatedWork W2167817538 @default.

• next