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- W2113143896 abstract "The condensin complex is a key determinant of higher-ordered chromosome structure. We show here that the complex is also important for the correct alignment of chromosomes on the meiosis I spindle. Unlike during mitosis and meiosis II, when sister chromatids attach to microtubules emanating from opposite spindle poles (biorientation), accurate meiosis I chromosome segregation requires that sister chromatids attach to microtubules emanating from the same spindle pole (co-orientation). The monopolin complex, consisting of Lrs4, Csm1, and the meiosis-specific component Mam1, brings about meiosis I co-orientation. We find that in the absence of functional condensin complexes, a fraction of sister kinetochores biorient on the meiosis I spindle and association of the monopolin complex subunit Mam1 with kinetochores is decreased. Our studies uncover a new locus-specific effect of the condensin complex." @default.
- W2113143896 created "2016-06-24" @default.
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- W2113143896 date "2010-05-01" @default.
- W2113143896 modified "2023-10-06" @default.
- W2113143896 title "Condensins Promote Coorientation of Sister Chromatids During Meiosis I in Budding Yeast" @default.
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- W2113143896 doi "https://doi.org/10.1534/genetics.110.115139" @default.
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