Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113144857> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2113144857 endingPage "730" @default.
- W2113144857 startingPage "727" @default.
- W2113144857 abstract "<h3>Objective</h3> To study the effects of early metformin treatment on menarche, height, and polycystic ovary syndrome (PCOS) markers. Low-birthweight (LBW) girls with precocious pubarche (PP) are at risk for an early menarche (<12 years), an adult stature below target level, and PCOS. Hyperinsulinemic insulin resistance is thought to be a key factor. <h3>Design</h3> Open-label, randomized study. <h3>Setting</h3> University hospital. <h3>Patient(s)</h3> Thirty-eight LBW-PP girls. <h3>Intervention(s)</h3> At age 8 years, girls were randomly assigned to remain untreated or to receive metformin for 4 years; subsequently, both subgroups were followed without treatment until each girl was postmenarcheal. <h3>Main Outcome Measure(s)</h3> Age at menarche, height, weight, endocrine-metabolic state (fasting blood), body composition (by absorptiometry), abdominal fat (subcutaneous vs. visceral), and hepatic adiposity (by magnetic resonance imaging). <h3>Result(s)</h3> At last assessment, girls in each subgroup were on average 2 years beyond menarche; the mean growth velocity was below 2 cm/years. Age at menarche was 11.4 ± 0.1 years in untreated girls and 12.5 ± 0.2 years in metformin-treated girls; the latter girls were taller and much leaner (with less visceral and hepatic fat) and had more favorable levels of circulating insulin, androgens, and lipids. <h3>Conclusion(s)</h3> Early metformin therapy (age ∼8–12 years) suffices to delay menarche; to augment postmenarcheal height; to reduce total, visceral, and hepatic adiposity; and to curb the endocrine-metabolic course of LBW-PP girls away from adolescent PCOS." @default.
- W2113144857 created "2016-06-24" @default.
- W2113144857 creator A5017184853 @default.
- W2113144857 creator A5028902231 @default.
- W2113144857 creator A5061145681 @default.
- W2113144857 creator A5063054543 @default.
- W2113144857 creator A5089989142 @default.
- W2113144857 date "2011-02-01" @default.
- W2113144857 modified "2023-10-13" @default.
- W2113144857 title "Early metformin therapy to delay menarche and augment height in girls with precocious pubarche" @default.
- W2113144857 cites W1965581512 @default.
- W2113144857 cites W1967114158 @default.
- W2113144857 cites W1983421009 @default.
- W2113144857 cites W2005004639 @default.
- W2113144857 cites W2033484016 @default.
- W2113144857 cites W2038616135 @default.
- W2113144857 cites W2043270389 @default.
- W2113144857 cites W2065739428 @default.
- W2113144857 cites W2071188087 @default.
- W2113144857 cites W2079229176 @default.
- W2113144857 cites W2080973499 @default.
- W2113144857 cites W2086664003 @default.
- W2113144857 cites W2092340120 @default.
- W2113144857 cites W2095157692 @default.
- W2113144857 cites W2097728522 @default.
- W2113144857 cites W2099233855 @default.
- W2113144857 cites W2099843584 @default.
- W2113144857 cites W2101053290 @default.
- W2113144857 doi "https://doi.org/10.1016/j.fertnstert.2010.08.052" @default.
- W2113144857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20883985" @default.
- W2113144857 hasPublicationYear "2011" @default.
- W2113144857 type Work @default.
- W2113144857 sameAs 2113144857 @default.
- W2113144857 citedByCount "56" @default.
- W2113144857 countsByYear W21131448572012 @default.
- W2113144857 countsByYear W21131448572013 @default.
- W2113144857 countsByYear W21131448572014 @default.
- W2113144857 countsByYear W21131448572015 @default.
- W2113144857 countsByYear W21131448572016 @default.
- W2113144857 countsByYear W21131448572017 @default.
- W2113144857 countsByYear W21131448572018 @default.
- W2113144857 countsByYear W21131448572019 @default.
- W2113144857 countsByYear W21131448572020 @default.
- W2113144857 countsByYear W21131448572021 @default.
- W2113144857 countsByYear W21131448572022 @default.
- W2113144857 countsByYear W21131448572023 @default.
- W2113144857 crossrefType "journal-article" @default.
- W2113144857 hasAuthorship W2113144857A5017184853 @default.
- W2113144857 hasAuthorship W2113144857A5028902231 @default.
- W2113144857 hasAuthorship W2113144857A5061145681 @default.
- W2113144857 hasAuthorship W2113144857A5063054543 @default.
- W2113144857 hasAuthorship W2113144857A5089989142 @default.
- W2113144857 hasBestOaLocation W21131448571 @default.
- W2113144857 hasConcept C121207290 @default.
- W2113144857 hasConcept C126322002 @default.
- W2113144857 hasConcept C134018914 @default.
- W2113144857 hasConcept C187212893 @default.
- W2113144857 hasConcept C2777391703 @default.
- W2113144857 hasConcept C2778367240 @default.
- W2113144857 hasConcept C2779306644 @default.
- W2113144857 hasConcept C2780323712 @default.
- W2113144857 hasConcept C3018442814 @default.
- W2113144857 hasConcept C4258228 @default.
- W2113144857 hasConcept C71315377 @default.
- W2113144857 hasConcept C71924100 @default.
- W2113144857 hasConceptScore W2113144857C121207290 @default.
- W2113144857 hasConceptScore W2113144857C126322002 @default.
- W2113144857 hasConceptScore W2113144857C134018914 @default.
- W2113144857 hasConceptScore W2113144857C187212893 @default.
- W2113144857 hasConceptScore W2113144857C2777391703 @default.
- W2113144857 hasConceptScore W2113144857C2778367240 @default.
- W2113144857 hasConceptScore W2113144857C2779306644 @default.
- W2113144857 hasConceptScore W2113144857C2780323712 @default.
- W2113144857 hasConceptScore W2113144857C3018442814 @default.
- W2113144857 hasConceptScore W2113144857C4258228 @default.
- W2113144857 hasConceptScore W2113144857C71315377 @default.
- W2113144857 hasConceptScore W2113144857C71924100 @default.
- W2113144857 hasFunder F4320323573 @default.
- W2113144857 hasIssue "2" @default.
- W2113144857 hasLocation W21131448571 @default.
- W2113144857 hasLocation W21131448572 @default.
- W2113144857 hasOpenAccess W2113144857 @default.
- W2113144857 hasPrimaryLocation W21131448571 @default.
- W2113144857 hasRelatedWork W1835582227 @default.
- W2113144857 hasRelatedWork W2022955668 @default.
- W2113144857 hasRelatedWork W2055600249 @default.
- W2113144857 hasRelatedWork W2082140668 @default.
- W2113144857 hasRelatedWork W2102089120 @default.
- W2113144857 hasRelatedWork W2744240433 @default.
- W2113144857 hasRelatedWork W2904480208 @default.
- W2113144857 hasRelatedWork W3028840175 @default.
- W2113144857 hasRelatedWork W4240163782 @default.
- W2113144857 hasRelatedWork W4246690683 @default.
- W2113144857 hasVolume "95" @default.
- W2113144857 isParatext "false" @default.
- W2113144857 isRetracted "false" @default.
- W2113144857 magId "2113144857" @default.
- W2113144857 workType "article" @default.