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• W2113146724 abstract "Significance There is considerable information about the spatial regulation of gene expression during pattern formation in animal development. Significantly less is known about temporal control, in part due to our inability to analyze gene activity in real time. Using a recently developed approach for the visualization of gene expression in living Drosophila embryos, we examined the well-known even-skipped stripe 2 expression pattern. Surprisingly, we observe that this classic pattern is quite transient and generated by discontinuous surges of transcriptional activity in individual cells. These results challenge a purely static framework for dissecting developmental programs and emphasize the importance of the dynamic features of pattern formation." @default.
• W2113146724 created "2016-06-24" @default.
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• W2113146724 date "2014-07-03" @default.
• W2113146724 modified "2023-10-12" @default.
• W2113146724 title "Dynamic regulation of <i>eve</i> stripe 2 expression reveals transcriptional bursts in living <i>Drosophila</i> embryos" @default.
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• W2113146724 doi "https://doi.org/10.1073/pnas.1410022111" @default.
• W2113146724 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4115566" @default.
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