Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113149589> ?p ?o ?g. }
- W2113149589 endingPage "4867" @default.
- W2113149589 startingPage "4858" @default.
- W2113149589 abstract "Mitochondria were simultaneously isolated from striatum and cortex of adult rats and compared in functional assays for their sensitivity to calcium activation of the permeability transition. Striatal mitochondria showed an increased dose-dependent sensitivity to Ca2+ compared with cortical mitochondria, as measured by mitochondrial depolarization, swelling, Ca2+ uptake, reactive oxygen species production, and respiration. Ratios of ATP to ADP were lower in striatal mitochondria exposed to calcium despite equal amounts of ADP and ATP under respiring and nonrespiring conditions. The Ca2+-induced changes were inhibited by cyclosporin A or ADP. These responses are consistent with Ca2+ activation of both low and high permeability pathways constituting the mitochondrial permeability transition. In addition to the striatal supersensitivity to induction of the permeability transition, cyclosporin A inhibition was less potent in striatal mitochondria. Immunoblots indicated that striatal mitochondria contained more cyclophilin D than cortical mitochondria. Thus striatal mitochondria may be selectively vulnerable to the permeability transition. Subsequent mitochondrial dysfunction could contribute to the initial toxicity of striatal neurons in Huntington's disease." @default.
- W2113149589 created "2016-06-24" @default.
- W2113149589 creator A5009271895 @default.
- W2113149589 creator A5040078383 @default.
- W2113149589 creator A5048322792 @default.
- W2113149589 creator A5052736411 @default.
- W2113149589 creator A5058483322 @default.
- W2113149589 creator A5065321916 @default.
- W2113149589 date "2003-06-15" @default.
- W2113149589 modified "2023-10-10" @default.
- W2113149589 title "Increased Susceptibility of Striatal Mitochondria to Calcium-Induced Permeability Transition" @default.
- W2113149589 cites W1492322138 @default.
- W2113149589 cites W1492823505 @default.
- W2113149589 cites W1500217596 @default.
- W2113149589 cites W1506478670 @default.
- W2113149589 cites W1554017667 @default.
- W2113149589 cites W1563847798 @default.
- W2113149589 cites W1565788467 @default.
- W2113149589 cites W1567313097 @default.
- W2113149589 cites W1578941035 @default.
- W2113149589 cites W1603109630 @default.
- W2113149589 cites W1603422612 @default.
- W2113149589 cites W1767614014 @default.
- W2113149589 cites W1849305538 @default.
- W2113149589 cites W1874250570 @default.
- W2113149589 cites W1909302202 @default.
- W2113149589 cites W1937565838 @default.
- W2113149589 cites W1949056714 @default.
- W2113149589 cites W1965359818 @default.
- W2113149589 cites W1968112618 @default.
- W2113149589 cites W1968746966 @default.
- W2113149589 cites W1968926794 @default.
- W2113149589 cites W1972353515 @default.
- W2113149589 cites W1972771185 @default.
- W2113149589 cites W1977779020 @default.
- W2113149589 cites W1981483033 @default.
- W2113149589 cites W1981902498 @default.
- W2113149589 cites W1982928579 @default.
- W2113149589 cites W1984065377 @default.
- W2113149589 cites W1985578394 @default.
- W2113149589 cites W1985977889 @default.
- W2113149589 cites W1995462290 @default.
- W2113149589 cites W1996024251 @default.
- W2113149589 cites W1997883336 @default.
- W2113149589 cites W2000987052 @default.
- W2113149589 cites W2005571058 @default.
- W2113149589 cites W2008348307 @default.
- W2113149589 cites W2008657946 @default.
- W2113149589 cites W2011966857 @default.
- W2113149589 cites W2014181404 @default.
- W2113149589 cites W2022767514 @default.
- W2113149589 cites W2023210589 @default.
- W2113149589 cites W2023555853 @default.
- W2113149589 cites W2023826599 @default.
- W2113149589 cites W2028248935 @default.
- W2113149589 cites W2029763785 @default.
- W2113149589 cites W2033023734 @default.
- W2113149589 cites W2033706242 @default.
- W2113149589 cites W2035873240 @default.
- W2113149589 cites W2045201746 @default.
- W2113149589 cites W2045989044 @default.
- W2113149589 cites W2046770259 @default.
- W2113149589 cites W2050769762 @default.
- W2113149589 cites W2052406949 @default.
- W2113149589 cites W2055534013 @default.
- W2113149589 cites W2057810394 @default.
- W2113149589 cites W2060363769 @default.
- W2113149589 cites W2063385957 @default.
- W2113149589 cites W2074570665 @default.
- W2113149589 cites W2076046725 @default.
- W2113149589 cites W2077298522 @default.
- W2113149589 cites W2083330566 @default.
- W2113149589 cites W2084728929 @default.
- W2113149589 cites W2088085303 @default.
- W2113149589 cites W2089346901 @default.
- W2113149589 cites W2090306035 @default.
- W2113149589 cites W2092728393 @default.
- W2113149589 cites W2093491661 @default.
- W2113149589 cites W2096426937 @default.
- W2113149589 cites W2098670658 @default.
- W2113149589 cites W2100293455 @default.
- W2113149589 cites W2102430316 @default.
- W2113149589 cites W2121589769 @default.
- W2113149589 cites W2128635872 @default.
- W2113149589 cites W2129609456 @default.
- W2113149589 cites W2131155959 @default.
- W2113149589 cites W2137670899 @default.
- W2113149589 cites W2147336824 @default.
- W2113149589 cites W2162920035 @default.
- W2113149589 cites W2169260084 @default.
- W2113149589 cites W2286242779 @default.
- W2113149589 cites W2298568012 @default.
- W2113149589 cites W2343853887 @default.
- W2113149589 cites W75010204 @default.
- W2113149589 cites W2082230307 @default.
- W2113149589 doi "https://doi.org/10.1523/jneurosci.23-12-04858.2003" @default.
- W2113149589 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6741171" @default.
- W2113149589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12832508" @default.