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• W2113150225 abstract "Among transcription factors that bind to bacterial RNA polymerase (RNAP) and modulate its activity, a number of small molecules irreversibly inhibit RNAP thereby causing cell death. To be of clinical significance such inhibitors must (1) inhibit a broad range of bacterial RNAPs but not affect human cells, (2) penetrate bacterial cell walls and (3) circumvent bacterial resistance mechanisms. Rifamycins, the only class of RNAP inhibitors that have found their way into clinical practice, are widely used in the treatment of tuberculosis and leprosy. However, the practical value of this class of antibiotics is limited by a rapid rise in resistant bacterial isolates. In this review we focus on recent advances in studies of prokaryotic transcription that allow a detailed structural and functional characterization of a number of RNAP/rifamycins complexes, thereby opening new opportunities for the design of superior antibacterial agents." @default.
• W2113150225 created "2016-06-24" @default.
• W2113150225 creator A5063187030 @default.
• W2113150225 creator A5076117636 @default.
• W2113150225 date "2006-01-24" @default.
• W2113150225 modified "2023-09-23" @default.
• W2113150225 title "Is It Easy to Stop RNA Polymerase?" @default.
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• W2113150225 doi "https://doi.org/10.4161/cc.5.4.2466" @default.
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• W2113150225 hasPublicationYear "2006" @default.
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