FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113151352> ?p ?o ?g. }

• W2113151352 endingPage "18" @default.
• W2113151352 startingPage "4809" @default.
• W2113151352 abstract "SR31747A is a sigma ligand with potent antiproliferative activity against tumor cells and for which three binding proteins have been identified to date: (a) SRBP-1 (also called sigma 1); (b) HIS; and (c) sigma 2. In this study, we characterized an additional SR31747A binding site, i.e., SRBP-2 (SR31747A-binding protein 2). Using an in silico screening approach, we identified this novel sequence, which exhibits 41% homology with HSI. The 1142-bp cDNA was found to encode a 206 amino acid protein not related to SRBP-1. Northern blot analysis of SRBP-2 mRNA expression revealed a single 1.1-kb transcript that was widely expressed in organs; the liver was particularly enriched, and the brain showed the lowest abundance. A murine homologue that exhibited a similar expression pattern was also characterized. Subcellular localization analysis using specific polyclonal antibodies revealed that SRBP-2 had the same nuclear membrane and endoplasmic reticulum localization as other members of the SR31747A-binding protein family. Considering SRBP-2-binding properties, pharmacological analysis clearly highlighted that SRBP-2 was distinct from sigma 2. Scatchard plot analysis revealed K(d) values of 10 and 3 nM for SR31747A and Tamoxifen, respectively. In contrast with HSI, the protein also did not exhibit detectable isomerase activity. When analyzing SRBP-2 expression in human breast cancer biopsies, we obtained evidence that SRBP-2 expression, together with SRBP-1 and HSI, may be of interest as a prognostic marker. These findings demonstrated that SRBP-2 represents an additional molecular target for SR31747A, which could help to understand the immunosuppressive and antiproliferative effects of the molecule." @default.
• W2113151352 created "2016-06-24" @default.
• W2113151352 creator A5000653236 @default.
• W2113151352 creator A5002828892 @default.
• W2113151352 creator A5013522865 @default.
• W2113151352 creator A5025803443 @default.
• W2113151352 creator A5031089086 @default.
• W2113151352 creator A5031788990 @default.
• W2113151352 creator A5035029864 @default.
• W2113151352 creator A5036658216 @default.
• W2113151352 creator A5040929926 @default.
• W2113151352 creator A5042721668 @default.
• W2113151352 creator A5048369934 @default.
• W2113151352 creator A5049285050 @default.
• W2113151352 date "2003-08-15" @default.
• W2113151352 modified "2023-10-18" @default.
• W2113151352 title "Identification and pharmacological characterization of SRBP-2: a novel SR31747A-binding protein." @default.
• W2113151352 cites W1486051248 @default.
• W2113151352 cites W1499672184 @default.
• W2113151352 cites W1579542460 @default.
• W2113151352 cites W1966937225 @default.
• W2113151352 cites W1972892706 @default.
• W2113151352 cites W2010711319 @default.
• W2113151352 cites W2010871781 @default.
• W2113151352 cites W2026692772 @default.
• W2113151352 cites W2027880172 @default.
• W2113151352 cites W2029055264 @default.
• W2113151352 cites W2041620107 @default.
• W2113151352 cites W2055182510 @default.
• W2113151352 cites W2062792722 @default.
• W2113151352 cites W2063333882 @default.
• W2113151352 cites W2086145169 @default.
• W2113151352 cites W2130518310 @default.
• W2113151352 cites W2133426419 @default.
• W2113151352 cites W2151459233 @default.
• W2113151352 cites W2159316863 @default.
• W2113151352 cites W2230423549 @default.
• W2113151352 cites W36065382 @default.
• W2113151352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12941800" @default.
• W2113151352 hasPublicationYear "2003" @default.
• W2113151352 type Work @default.
• W2113151352 sameAs 2113151352 @default.
• W2113151352 citedByCount "5" @default.
• W2113151352 countsByYear W21131513522014 @default.
• W2113151352 countsByYear W21131513522023 @default.
• W2113151352 crossrefType "journal-article" @default.
• W2113151352 hasAuthorship W2113151352A5000653236 @default.
• W2113151352 hasAuthorship W2113151352A5002828892 @default.
• W2113151352 hasAuthorship W2113151352A5013522865 @default.
• W2113151352 hasAuthorship W2113151352A5025803443 @default.
• W2113151352 hasAuthorship W2113151352A5031089086 @default.
• W2113151352 hasAuthorship W2113151352A5031788990 @default.
• W2113151352 hasAuthorship W2113151352A5035029864 @default.
• W2113151352 hasAuthorship W2113151352A5036658216 @default.
• W2113151352 hasAuthorship W2113151352A5040929926 @default.
• W2113151352 hasAuthorship W2113151352A5042721668 @default.
• W2113151352 hasAuthorship W2113151352A5048369934 @default.
• W2113151352 hasAuthorship W2113151352A5049285050 @default.
• W2113151352 hasConcept C104317684 @default.
• W2113151352 hasConcept C107824862 @default.
• W2113151352 hasConcept C153911025 @default.
• W2113151352 hasConcept C158617107 @default.
• W2113151352 hasConcept C187882448 @default.
• W2113151352 hasConcept C2775905019 @default.
• W2113151352 hasConcept C2776415932 @default.
• W2113151352 hasConcept C2776879804 @default.
• W2113151352 hasConcept C553089730 @default.
• W2113151352 hasConcept C55493867 @default.
• W2113151352 hasConcept C86803240 @default.
• W2113151352 hasConceptScore W2113151352C104317684 @default.
• W2113151352 hasConceptScore W2113151352C107824862 @default.
• W2113151352 hasConceptScore W2113151352C153911025 @default.
• W2113151352 hasConceptScore W2113151352C158617107 @default.
• W2113151352 hasConceptScore W2113151352C187882448 @default.
• W2113151352 hasConceptScore W2113151352C2775905019 @default.
• W2113151352 hasConceptScore W2113151352C2776415932 @default.
• W2113151352 hasConceptScore W2113151352C2776879804 @default.
• W2113151352 hasConceptScore W2113151352C553089730 @default.
• W2113151352 hasConceptScore W2113151352C55493867 @default.
• W2113151352 hasConceptScore W2113151352C86803240 @default.
• W2113151352 hasIssue "16" @default.
• W2113151352 hasLocation W21131513521 @default.
• W2113151352 hasOpenAccess W2113151352 @default.
• W2113151352 hasPrimaryLocation W21131513521 @default.
• W2113151352 hasRelatedWork W1512178996 @default.
• W2113151352 hasRelatedWork W1913100483 @default.
• W2113151352 hasRelatedWork W1975781565 @default.
• W2113151352 hasRelatedWork W2019889596 @default.
• W2113151352 hasRelatedWork W2021572552 @default.
• W2113151352 hasRelatedWork W2044438401 @default.
• W2113151352 hasRelatedWork W2113151352 @default.
• W2113151352 hasRelatedWork W2349455210 @default.
• W2113151352 hasRelatedWork W2353785661 @default.
• W2113151352 hasRelatedWork W3026307143 @default.
• W2113151352 hasVolume "63" @default.
• W2113151352 isParatext "false" @default.
• W2113151352 isRetracted "false" @default.
• W2113151352 magId "2113151352" @default.

• next