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• W2113157002 abstract "CD8(+) T cells in different activation states have been difficult to identify phenotypically. In this study we have investigated whether Mac-1 (CD11b) expression can be used as a criterion to distinguish between recently activated effector cells and memory cells belonging to the CD8(+) T cell subset. Polyclonal virus-specific effector and memory CD8(+) T cells from lymphocytic choriomeningitis- and vesicular stomatitis virus-infected mice were visualized through staining for intracellular IFN-gamma or binding of MHC-peptide tetramers, and Mac-1 expression was evaluated. Naive T cells and most virus-specific memory CD8(+) T cells express little or no Mac-1 independent of the virus model employed. In contrast, the majority of CD8(+) T cells present during acute infection express a significant level of Mac-1 and, similarly, Mac-1 expression is found on secondary effectors generated in response to viral re-exposure. We therefore suggest that high Mac-1 expression defines a subset of circulating effector cells and that the presence of this marker on antigen-specific CD8(+) T cells signifies recent activation." @default.
• W2113157002 created "2016-06-24" @default.
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• W2113157002 date "2001-04-01" @default.
• W2113157002 modified "2023-09-30" @default.
• W2113157002 title "CD11b expression as a marker to distinguish between recently activated effector CD8+ T cells and memory cells" @default.
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• W2113157002 doi "https://doi.org/10.1093/intimm/13.4.593" @default.
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