FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113157633> ?p ?o ?g. }

• W2113157633 endingPage "1534" @default.
• W2113157633 startingPage "1524" @default.
• W2113157633 abstract "Two models of colitis produced in rats that have received significant attention over the past few years are the acetic acid and trinitrobenzene sulfonic acid (TNBS) models. The objective of this study was to quantify and compare the temporal relationship among mucosal permeability, epithelial injury, and inflammation induced by acetic acid, ethanol (vehicle), ethanol plus TNBS (unbuffered, pH 1.0), and ethanol plus TNBS (pH 7.4). Data obtained show that the inflammation induced by these four irritants results from caustic injury to the colonic epithelium and interstitium as measured by the rapid and dramatic increases in mucosal permeability and tissue water content as well as by histological analysis. The injurious nature of TNBS was confirmed in a separate series of studies showing that buffered TNBS (pH 7.4), in the absence of ethanol, is toxic to cultured rat intestinal epithelial cell monolayers. Only after 1-2 days of the initial insult, were signs of classical inflammation observed, including increases in colonic myeloperoxidase activity (neutrophil infiltration) and colon weight as well as hyperemia and mucosal ulcerations. Although ethanol plus TNBS (pH 1.0 or 7.4) tended to produce higher mucosal permeabilities (epithelial cell injury) at 1-2 weeks after the enemas than acetic acid or ethanol groups, only the ethanol plus TNBS (pH 7.4) permeabilities were found to be significantly enhanced. In addition, all four groups showed significant elevations in colonic myeloperoxidase activity and colon weight at 1-2 weeks after enema. It is suggested that these models of colitis are useful to study events that occur at the time of inflammation and repair. However, these models may have significant limitations in understanding events that initiate inflammation of the intestine in human inflammatory bowel disease." @default.
• W2113157633 created "2016-06-24" @default.
• W2113157633 creator A5001318537 @default.
• W2113157633 creator A5013188412 @default.
• W2113157633 creator A5014512255 @default.
• W2113157633 creator A5059529660 @default.
• W2113157633 date "1992-05-01" @default.
• W2113157633 modified "2023-09-30" @default.
• W2113157633 title "A comparative analysis of two models of colitis in rats" @default.
• W2113157633 cites W1499561896 @default.
• W2113157633 cites W1519428830 @default.
• W2113157633 cites W1619545133 @default.
• W2113157633 cites W1648036481 @default.
• W2113157633 cites W1773726348 @default.
• W2113157633 cites W1786438081 @default.
• W2113157633 cites W1815207518 @default.
• W2113157633 cites W184167452 @default.
• W2113157633 cites W1937054431 @default.
• W2113157633 cites W1980581142 @default.
• W2113157633 cites W1983905815 @default.
• W2113157633 cites W2001222463 @default.
• W2113157633 cites W2053963205 @default.
• W2113157633 cites W2060244869 @default.
• W2113157633 cites W2107923742 @default.
• W2113157633 cites W2138585310 @default.
• W2113157633 cites W4254679467 @default.
• W2113157633 doi "https://doi.org/10.1016/0016-5085(92)91710-l" @default.
• W2113157633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1314749" @default.
• W2113157633 hasPublicationYear "1992" @default.
• W2113157633 type Work @default.
• W2113157633 sameAs 2113157633 @default.
• W2113157633 citedByCount "250" @default.
• W2113157633 countsByYear W21131576332012 @default.
• W2113157633 countsByYear W21131576332013 @default.
• W2113157633 countsByYear W21131576332014 @default.
• W2113157633 countsByYear W21131576332015 @default.
• W2113157633 countsByYear W21131576332016 @default.
• W2113157633 countsByYear W21131576332017 @default.
• W2113157633 countsByYear W21131576332018 @default.
• W2113157633 countsByYear W21131576332020 @default.
• W2113157633 countsByYear W21131576332021 @default.
• W2113157633 countsByYear W21131576332022 @default.
• W2113157633 countsByYear W21131576332023 @default.
• W2113157633 crossrefType "journal-article" @default.
• W2113157633 hasAuthorship W2113157633A5001318537 @default.
• W2113157633 hasAuthorship W2113157633A5013188412 @default.
• W2113157633 hasAuthorship W2113157633A5014512255 @default.
• W2113157633 hasAuthorship W2113157633A5059529660 @default.
• W2113157633 hasConcept C121332964 @default.
• W2113157633 hasConcept C126322002 @default.
• W2113157633 hasConcept C142724271 @default.
• W2113157633 hasConcept C153400128 @default.
• W2113157633 hasConcept C185592680 @default.
• W2113157633 hasConcept C203565725 @default.
• W2113157633 hasConcept C2775862500 @default.
• W2113157633 hasConcept C2776530707 @default.
• W2113157633 hasConcept C2776673659 @default.
• W2113157633 hasConcept C2776914184 @default.
• W2113157633 hasConcept C2780161600 @default.
• W2113157633 hasConcept C55493867 @default.
• W2113157633 hasConcept C71924100 @default.
• W2113157633 hasConcept C90924648 @default.
• W2113157633 hasConcept C97355855 @default.
• W2113157633 hasConcept C98274493 @default.
• W2113157633 hasConceptScore W2113157633C121332964 @default.
• W2113157633 hasConceptScore W2113157633C126322002 @default.
• W2113157633 hasConceptScore W2113157633C142724271 @default.
• W2113157633 hasConceptScore W2113157633C153400128 @default.
• W2113157633 hasConceptScore W2113157633C185592680 @default.
• W2113157633 hasConceptScore W2113157633C203565725 @default.
• W2113157633 hasConceptScore W2113157633C2775862500 @default.
• W2113157633 hasConceptScore W2113157633C2776530707 @default.
• W2113157633 hasConceptScore W2113157633C2776673659 @default.
• W2113157633 hasConceptScore W2113157633C2776914184 @default.
• W2113157633 hasConceptScore W2113157633C2780161600 @default.
• W2113157633 hasConceptScore W2113157633C55493867 @default.
• W2113157633 hasConceptScore W2113157633C71924100 @default.
• W2113157633 hasConceptScore W2113157633C90924648 @default.
• W2113157633 hasConceptScore W2113157633C97355855 @default.
• W2113157633 hasConceptScore W2113157633C98274493 @default.
• W2113157633 hasIssue "5" @default.
• W2113157633 hasLocation W21131576331 @default.
• W2113157633 hasLocation W21131576332 @default.
• W2113157633 hasOpenAccess W2113157633 @default.
• W2113157633 hasPrimaryLocation W21131576331 @default.
• W2113157633 hasRelatedWork W1840785378 @default.
• W2113157633 hasRelatedWork W1963617522 @default.
• W2113157633 hasRelatedWork W1965801193 @default.
• W2113157633 hasRelatedWork W2059446938 @default.
• W2113157633 hasRelatedWork W2359690154 @default.
• W2113157633 hasRelatedWork W2360421083 @default.
• W2113157633 hasRelatedWork W3029563330 @default.
• W2113157633 hasRelatedWork W4310920115 @default.
• W2113157633 hasRelatedWork W4313351790 @default.
• W2113157633 hasRelatedWork W4323320151 @default.
• W2113157633 hasVolume "102" @default.
• W2113157633 isParatext "false" @default.
• W2113157633 isRetracted "false" @default.

• next