FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113159483> ?p ?o ?g. }

• W2113159483 endingPage "850" @default.
• W2113159483 startingPage "842" @default.
• W2113159483 abstract "1. The purine nucleotide adenosine-5'-triphosphate (ATP) exerts pronounced effects on the cardiovascular system. The mechanism of action of the vasodilator response to ATP in humans has not been elucidated yet. The proposed endothelium-derived relaxing factors (EDRFs) were studied in a series of experiments, using the perfused forearm technique. 2. Adenosine 5'-triphosphate (0.2, 0.6, 6 and 20 nmol dl(-1) forearm volume min(-1)) evoked a dose-dependent forearm vasodilator response, which could not be inhibited by separate infusion of the nonselective COX inhibitor indomethacin (5 microg dl(-1) min(-1), n=10), the blocker of Na(+)/K(+)-ATPase ouabain (0.2 microg dl(-1) min(-1), n=8), the blocker of K(Ca) channels tetraethylammonium chloride (TEA, 0.1 microg dl(-1) min(-1), n=10), nor by the K(ATP)-channel blocker glibenclamide (2 microg dl(-1) min(-1), n=10). All blockers, except glibenclamide, caused a significant increase in baseline vascular tone. The obtained results might be due to compensatory actions of unblocked EDRFs. Combined infusion of TEA, indomethacin and l-NMMA (n=6) significantly increased the baseline forearm vascular resistance. The ATP-induced relative decreases in forearm vascular resistance were 48+/-5, 67+/-3, 88+/-2, and 92+/-2% in the absence and 23+/-7, 62+/-4, 89+/-2, and 93+/-1% in the presence of the combination of TEA, indomethacin and l-NMMA (P<0.05, repeated-measures ANOVA, n=6). A similar inhibition was obtained for sodium nitroprusside (SNP, P<0.05 repeated-measures ANOVA, n=6), indicating a nonspecific interaction due to the blocker-induced vasoconstriction. 3. ATP-induced vasodilation in the human forearm cannot be inhibited by separate infusion of indomethacin, ouabain, glibenclamide or TEA, or by a combined infusion of TEA, indomethacin, and l-NMMA. Endothelium-independent mechanisms and involvement of unblocked EDRFs, such as CO, might play a role, and call for further studies." @default.
• W2113159483 created "2016-06-24" @default.
• W2113159483 creator A5002755456 @default.
• W2113159483 creator A5014715968 @default.
• W2113159483 creator A5031328599 @default.
• W2113159483 creator A5034404496 @default.
• W2113159483 creator A5086811992 @default.
• W2113159483 date "2004-03-01" @default.
• W2113159483 modified "2023-10-14" @default.
• W2113159483 title "ATP-induced vasodilation in human skeletal muscle" @default.
• W2113159483 cites W1546802604 @default.
• W2113159483 cites W1753089048 @default.
• W2113159483 cites W1792503367 @default.
• W2113159483 cites W1912513757 @default.
• W2113159483 cites W1947888345 @default.
• W2113159483 cites W1971166643 @default.
• W2113159483 cites W1971169490 @default.
• W2113159483 cites W1981435557 @default.
• W2113159483 cites W1982136199 @default.
• W2113159483 cites W1985569157 @default.
• W2113159483 cites W1996588936 @default.
• W2113159483 cites W2006005195 @default.
• W2113159483 cites W2012223673 @default.
• W2113159483 cites W2013376946 @default.
• W2113159483 cites W2017951159 @default.
• W2113159483 cites W2021783313 @default.
• W2113159483 cites W2029169586 @default.
• W2113159483 cites W202976685 @default.
• W2113159483 cites W2030063927 @default.
• W2113159483 cites W2035886301 @default.
• W2113159483 cites W2041001842 @default.
• W2113159483 cites W2053754499 @default.
• W2113159483 cites W2061846540 @default.
• W2113159483 cites W2062845572 @default.
• W2113159483 cites W2066602748 @default.
• W2113159483 cites W2067158465 @default.
• W2113159483 cites W2067696654 @default.
• W2113159483 cites W2071969879 @default.
• W2113159483 cites W2072412880 @default.
• W2113159483 cites W2073675726 @default.
• W2113159483 cites W2076578577 @default.
• W2113159483 cites W2077419347 @default.
• W2113159483 cites W2080722127 @default.
• W2113159483 cites W2083835602 @default.
• W2113159483 cites W2088745867 @default.
• W2113159483 cites W2094737861 @default.
• W2113159483 cites W2094816625 @default.
• W2113159483 cites W2095431610 @default.
• W2113159483 cites W2098240280 @default.
• W2113159483 cites W2099642241 @default.
• W2113159483 cites W2099757747 @default.
• W2113159483 cites W2104435863 @default.
• W2113159483 cites W2105066493 @default.
• W2113159483 cites W2107300948 @default.
• W2113159483 cites W2107826105 @default.
• W2113159483 cites W2109969553 @default.
• W2113159483 cites W2121612337 @default.
• W2113159483 cites W2125001132 @default.
• W2113159483 cites W2131163999 @default.
• W2113159483 cites W2138033933 @default.
• W2113159483 cites W2152936240 @default.
• W2113159483 cites W2164878884 @default.
• W2113159483 cites W2187614311 @default.
• W2113159483 cites W2187959958 @default.
• W2113159483 cites W2219071922 @default.
• W2113159483 cites W2224388738 @default.
• W2113159483 cites W2245939825 @default.
• W2113159483 cites W2304879987 @default.
• W2113159483 cites W2405788571 @default.
• W2113159483 cites W4251274485 @default.
• W2113159483 cites W45519859 @default.
• W2113159483 cites W65957098 @default.
• W2113159483 doi "https://doi.org/10.1038/sj.bjp.0705589" @default.
• W2113159483 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1574250" @default.
• W2113159483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14769779" @default.
• W2113159483 hasPublicationYear "2004" @default.
• W2113159483 type Work @default.
• W2113159483 sameAs 2113159483 @default.
• W2113159483 citedByCount "25" @default.
• W2113159483 countsByYear W21131594832012 @default.
• W2113159483 countsByYear W21131594832013 @default.
• W2113159483 countsByYear W21131594832014 @default.
• W2113159483 countsByYear W21131594832016 @default.
• W2113159483 countsByYear W21131594832017 @default.
• W2113159483 countsByYear W21131594832018 @default.
• W2113159483 countsByYear W21131594832019 @default.
• W2113159483 countsByYear W21131594832021 @default.
• W2113159483 countsByYear W21131594832022 @default.
• W2113159483 crossrefType "journal-article" @default.
• W2113159483 hasAuthorship W2113159483A5002755456 @default.
• W2113159483 hasAuthorship W2113159483A5014715968 @default.
• W2113159483 hasAuthorship W2113159483A5031328599 @default.
• W2113159483 hasAuthorship W2113159483A5034404496 @default.
• W2113159483 hasAuthorship W2113159483A5086811992 @default.
• W2113159483 hasBestOaLocation W21131594831 @default.
• W2113159483 hasConcept C105702510 @default.
• W2113159483 hasConcept C120770815 @default.
• W2113159483 hasConcept C126322002 @default.

• next